The 3C-like protease (3CLpro) or main protease (Mpro), formally known as C30 endopeptidase or 3-chymotrypsin-like protease, is the main protease found...
17 KB (1,651 words) - 07:02, 9 July 2024
Nirmatrelvir (category SARS-CoV-2 main protease inhibitors)
antiviral medication developed by Pfizer which acts as an orally active 3C-like protease inhibitor. It is part of a nirmatrelvir/ritonavir combination used...
25 KB (2,022 words) - 16:13, 18 June 2024
COVID-19. It is a combination of nirmatrelvir, a protease inhibitor targeted to the SARS-CoV-2 3C-like protease, and ritonavir, which inhibits the metabolism...
12 KB (838 words) - 10:11, 12 August 2024
Calicivirin (redirect from Calicivirus 3C-like protease)
trypsin-like cysteine protease, calicivirus TCP, calicivirus 3C-like protease, calicivirus endopeptidase, rabbit hemorrhagic disease virus 3C endopeptidase)...
3 KB (300 words) - 21:28, 28 July 2024
eukaryotes. A characteristic of the group is a conserved 3C-like protease from the PA clan of proteases for processing the translated polyprotein. The name...
3 KB (241 words) - 12:51, 30 January 2023
Papain-like proteases (or papain-like (cysteine) peptidases; abbreviated PLP or PLCP) are a large protein family of cysteine protease enzymes that share...
22 KB (2,189 words) - 07:46, 4 August 2024
Norovirus (redirect from Norwalk-like viruses)
into six smaller non-structural proteins (NS1/2 to NS7) by the viral 3C-like protease (NS6), a major structural protein (VP1) of about 58~60 kDa and a minor...
62 KB (6,323 words) - 14:12, 4 August 2024
functioning new viral proteins. They are particularly interested in proteases such as 3C-like protease (Mpro), a coronavirus nonstructural protein that mediates...
29 KB (2,927 words) - 00:40, 18 July 2024
which was discovered in the 1960s. The molecule is an inhibitor of the 3C-like protease of SARS-CoV-1 and SARS-CoV-2. Sarpogrelate Ketanserin Ritanserin Neuman...
3 KB (231 words) - 04:25, 12 August 2024
proteins within the polyprotein. A second protease also encoded by ORF1a, called the 3C-like protease or main protease, is responsible for the majority of further...
11 KB (1,085 words) - 13:29, 22 May 2024
RG (January 2006). "Treating HCV with ribavirin analogues and ribavirin-like molecules". The Journal of Antimicrobial Chemotherapy. 57 (1): 8–13. doi:10...
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; Meadows, J. M.; Chang, K. O. (13 September 2017). "Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis"...
26 KB (2,928 words) - 22:21, 21 July 2024
Ensitrelvir (category SARS-CoV-2 main protease inhibitors)
partnership with Hokkaido University and acts as an orally active 3C-like protease inhibitor. It is taken by mouth. The most common adverse events include...
16 KB (1,126 words) - 09:51, 6 August 2024
GC376 (category SARS-CoV-2 main protease inhibitors)
Kankanamalage AC, Eckstrand C, Groutas WC, et al. (April 2018). "Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis"...
8 KB (624 words) - 04:00, 9 August 2024
on cannabinoids it was found that 11-OH-Δ9-THC had the 3rd highest 3C-like protease inhibitor activity against COVID-19 out of all the cannabinoids tested...
7 KB (650 words) - 16:31, 28 April 2024
Picornain 3C (EC 3.4.22.28) is a protease found in picornaviruses, which cleaves peptide bonds of non-terminal sequences. Picornain 3C’s endopeptidase...
19 KB (2,412 words) - 14:53, 29 September 2023
is a member of the PA clan of chymotrypsin-like proteases. Due to its high sequence specificity, TEV protease is frequently used for the controlled cleavage...
16 KB (1,866 words) - 02:28, 14 August 2024
The total number of deaths attributed to the virus was 6,881,955. 3C-like protease (NS5) Solodovnikov A, Arkhipova V (29 July 2021). "Достоверно красиво:...
122 KB (12,462 words) - 03:40, 15 August 2024
attached to the 5'-end of the genome and a conserved 3C-like protease from the PA clan of proteases for processing the translated polyprotein. The name...
2 KB (212 words) - 22:36, 8 January 2024
Nirmatrelvir/ritonavir (category SARS-CoV-2 main protease inhibitors)
had been demonstrated in vitro. Nirmatrelvir belongs to a family of 3C-like protease inhibitors developed in the late 2010s against feline coronavirus,...
66 KB (5,974 words) - 22:20, 23 July 2024
"The arterivirus nsp4 protease is the prototype of a novel group of chymotrypsin-like enzymes, the 3C-like serine proteases". The Journal of Biological...
19 KB (1,689 words) - 07:38, 3 June 2024
Ritonavir (category HIV protease inhibitors)
combination of ritonavir with nirmatrelvir, a newly developed orally active 3C-like protease inhibitor, was developed for the treatment of COVID-19. Ritonavir serves...
42 KB (3,598 words) - 14:41, 6 August 2024
Zn-cluster binding domain fused with a helicase (HEL1); 3CLpro is a 3C-like protease; and NendoU is an uridylate-specific endonuclease. The 3CLpro has a...
9 KB (895 words) - 19:57, 26 March 2024
Island on phytocannabinoids it was found that THC-Butyl had the highest 3C-like protease inhibitor activity against COVID-19 out of all the phytocannabinoids...
7 KB (592 words) - 07:46, 9 June 2024
C-30 C30, a compact audio cassette C30 endopeptidase, also called 3C-like protease This disambiguation page lists articles associated with the same title...
1 KB (204 words) - 01:33, 18 September 2022
partnership with Hokkaido University and acts as an orally active 3C-like protease inhibitor. It is taken by mouth. The most common adverse events include...
90 KB (13,103 words) - 04:28, 26 July 2024
Articles Zhavoronkov, A., et al., "Potential non-covalent SARS-CoV-2 3C-like protease inhibitors designed using generative deep learning approaches and reviewed...
16 KB (1,379 words) - 17:43, 11 August 2024
making it an attractive therapeutic target. Unlike the viral enzymes (protease, reverse transcriptase and integrase) that are currently targeted by small-molecule...
13 KB (1,461 words) - 20:04, 15 May 2024
Island on phytocannabinoids it was found that CBGA had the 2nd highest 3C-like protease inhibitor activity against COVID-19 out of all the phytocannabinoids...
6 KB (597 words) - 02:10, 15 August 2024
performed by two proteases: the papain-like protease protein domain located in the multidomain protein nsp3 cleaves up to nsp4, and the 3CL protease (also known...
17 KB (1,381 words) - 00:22, 3 December 2023