formylglycinamidine ribonucleotide (FGAM). Dehydration of FGAM by enzyme FGAM cyclase results in the closure of the imidazole ring, as 5-aminoimidazole ribonucleotide (AIR)...
22 KB (2,619 words) - 04:46, 29 October 2024
5′-Phosphoribosyl-5-aminoimidazole (or aminoimidazole ribotide, AIR) is a biochemical intermediate in the formation of purine nucleotides via inosine-5-monophosphate...
14 KB (1,236 words) - 20:13, 5 July 2024
5′-Phosphoribosyl-4-carboxy-5-aminoimidazole (or CAIR) is an intermediate in the formation of purines. It is formed by phosphoribosylaminoimidazole carboxylase...
2 KB (25 words) - 14:48, 27 April 2023
5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) is an intermediate in the generation of inosine monophosphate. AICAR is an analog of adenosine monophosphate...
9 KB (819 words) - 22:40, 9 September 2023
carboxyl group of the imidazole ring, forming N-succinyl-5-aminoimidazole-4-carboxamide ribonucleotide (SAICAR). SAICAR lyase removes the carbon skeleton of...
61 KB (6,770 words) - 15:11, 20 August 2024
Phosphoribosylaminoimidazole carboxylase (redirect from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase (5-amino-1-(5-phospho-D-ribosyl)imidazole-forming))
5'-phosphoribosyl-5-aminoimidazole ("AIR") into 5'-phosphoribosyl-4-carboxy-5-aminoimidazole ("CAIR") as described in the reaction: 5-aminoimidazole ribonucleotide...
4 KB (325 words) - 02:00, 10 March 2024
carboxylate of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to generate 4-carboxy-5-aminoimidazole ribonucleotide catalyzed by Escherichia coli PurE,...
4 KB (384 words) - 12:44, 26 August 2023
Phosphoribosylaminoimidazolesuccinocarboxamide synthase (redirect from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate:L-aspartate ligase (ADP-forming))
chicken liver cDNA encoding 5-aminoimidazole ribonucleotide carboxylase and 5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase by functional...
8 KB (844 words) - 02:33, 3 December 2023
FGAR + tetrahydrofolate 5-Aminoimidazole ribotide Purine metabolism R. Caspi (2009-01-13). "Pathway: 5-aminoimidazole ribonucleotide biosynthesis I". MetaCyc...
6 KB (375 words) - 16:01, 2 May 2023
Phosphoribosylamine (redirect from 5-phosphoribosylamine)
ATP → GAR + ADP + Pi 5-Aminoimidazole ribotide Purine metabolism R. Caspi (2009-01-13). "Pathway: 5-aminoimidazole ribonucleotide biosynthesis I". MetaCyc...
5 KB (359 words) - 19:12, 15 February 2022
ATP, L-aspartate, and 5-aminoimidazole-4-carboxyribonucleotide (CAIR) to 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide, ADP, and phosphate by...
3 KB (84 words) - 00:03, 24 September 2024
Phosphoribosyl pyrophosphate (redirect from 5-phosphoribosyl-1-pyrophosphate)
salvage. 5-Aminoimidazole ribotide Purine biosynthesis Pyrimidine biosynthesis R. Caspi (2009-01-13). "Pathway: 5-aminoimidazole ribonucleotide biosynthesis...
11 KB (921 words) - 11:15, 20 October 2023
AIR synthetase (FGAM cyclase) (redirect from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming))
reaction to form 5-aminoimidazole ribotide (AIR) from formylglycinamidine-ribonucleotide FGAM. This reaction closes the ring and produces a 5-membered imidazole...
5 KB (578 words) - 16:03, 15 March 2024
Pi + H+ Purine metabolism R. Caspi (2009-01-13). "Pathway: 5-aminoimidazole ribonucleotide biosynthesis I". MetaCyc Metabolic Pathway Database. Retrieved...
5 KB (331 words) - 16:26, 23 January 2023
ADP + glutamate + Pi 5-Aminoimidazole ribotide Purine metabolism R. Caspi (2009-01-13). "Pathway: 5-aminoimidazole ribonucleotide biosynthesis I". MetaCyc...
5 KB (344 words) - 16:48, 6 May 2023
Phosphoribosylglycinamide formyltransferase (redirect from 2-amino-N-ribosylacetamide 5'-phosphate transformylase)
glycinamide ribonucleotide synthase (GARS) and aminoimidazole ribonucleotide synthetase (AIRS). This protein (110kDa) catalyzes steps 2, 3 and 5 of de novo...
16 KB (1,773 words) - 17:07, 15 March 2024
aminoimidazole carboxamide ribonucleotide. It has two functions: EC 2.1.2.3 - 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase EC 3.5.4...
7 KB (788 words) - 03:29, 27 January 2024
inhibitors while PRPP is an activator. Between the formation of 5'-phosphoribosyl, aminoimidazole and IMP, there is no known regulation step. Purines from turnover...
15 KB (1,637 words) - 01:03, 23 August 2024
(1986). "Assignment of a third purine biosynthetic gene (glycinamide ribonucleotide transformylase) to human chromosome 21". American Journal of Human Genetics...
17 KB (1,672 words) - 04:19, 16 September 2024
into monomethylhydrazine, likely the active methylating agent, and 5-aminoimidazole-4-carboxamide (AIC).[medical citation needed] Other metabolites include...
33 KB (2,959 words) - 02:09, 16 July 2024
Nonenzymatic RNA Copying with 2‑Aminoimidazole Activated Nucleotides". Journal of the American Chemical Society. 139 (5): 1810–1813. doi:10.1021/jacs.6b13148...
8 KB (872 words) - 01:31, 8 January 2024
reactions are catalyzed by the enzymes glycinamide ribonucleotide (GAR) transformylase and 5-aminoimidazole-4-carboxyamide ribotide (AICAR) transformylase...
25 KB (2,838 words) - 17:20, 5 October 2024
Trifunctional purine biosynthetic protein adenosine-3 (redirect from Glycinamide ribonucleotide formyltransferase)
complex structures of a chemotherapeutic target: human glycinamide ribonucleotide transformylase". Biochemistry. 44 (29): 9841–50. doi:10.1021/bi050307g...
7 KB (960 words) - 17:18, 20 November 2023
Phosphoribosylamine—glycine ligase (redirect from 5-phospho-D-ribosylamine:glycine ligase (ADP-forming))
Liver Proteins That Catalyze Glycinamide Ribonucleotide Synthesis and Formylation and Aminoimidazole Ribonucleotide Synthesis". Biochemistry. 25 (10): 2953–2957...
12 KB (1,201 words) - 14:15, 22 September 2024
3892/ol.2018.9856. PMC 6341817. PMID 30675269. "ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase [Homo sapiens (Human)]...
33 KB (3,914 words) - 20:05, 30 August 2023
of N-[(5-phosphoribosyl) formimino]-5-aminoimidazole-4-carboxamide ribonucleotide (ProFAR) to N-[(5-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamide...
46 KB (4,820 words) - 13:28, 10 September 2024
but also has effects on DHFR, aminoimidazole carboxamide ribonucleotide formyltransferase and glycinamide ribonucleotide formyltransferase. The fluoropyrimidines...
155 KB (17,518 words) - 23:36, 26 October 2024
0000000000001449. PMID 32412717. S2CID 213450901. "ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase [Homo sapiens (Human)]...
42 KB (5,288 words) - 13:09, 4 October 2024
In the first reaction, ASL converts 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR) to 5-aminoimidazole-4-carboxamide ribotide (AICAR) and...
20 KB (2,387 words) - 03:01, 22 December 2023
domains (GARs-AIRs-GARt; GAR: glycinamide ribonucleotide synthetase/transferase; AIR: aminoimidazole ribonucleotide synthetase). In insects, the polypeptide...
71 KB (8,443 words) - 19:00, 15 August 2024