5-Hydroxymethylcytosine (5hmC) is a DNA pyrimidine nitrogen base derived from cytosine. It is potentially important in epigenetics, because the hydroxymethyl...
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Bisulfite sequencing (section 5-Hydroxymethylcytosine)
discovery of a new mammalian DNA modification 5-hydroxymethylcytosine. 5-Hydroxymethylcytosine converts to cytosine-5-methylsulfonate upon bisulfite treatment...
34 KB (4,084 words) - 21:59, 8 January 2024
methylated into 5-methylcytosine by an enzyme called DNA methyltransferase or be methylated and hydroxylated to make 5-hydroxymethylcytosine. The difference...
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demethylation, a series of oxidations converts it to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC), and the latter two...
23 KB (2,630 words) - 19:42, 14 June 2024
methylcytosine to 5-hydroxymethylcytosine. The first mechanistic reports showed tissue-specific accumulation of 5-hydroxymethylcytosine (5hmC) and the conversion...
25 KB (2,576 words) - 13:09, 21 January 2024
standalone epigenetic marker. In mammals, 5fC is formed by oxidation of 5-Hydroxymethylcytosine (5hmC) a reaction mediated by TET enzymes. Its molecular formula...
9 KB (917 words) - 13:13, 24 May 2023
DNA 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), and can further catalyse oxidation of 5hmC to 5-formylcytosine (5fC) and then to 5-carboxycytosine...
32 KB (3,984 words) - 05:42, 27 April 2024
for having invented TAB-seq, a biochemical method that can map 5-hydroxymethylcytosine (5hmC) at base-resolution genome-wide, as well as hmC-Seal, a method...
178 KB (18,218 words) - 14:10, 18 August 2024
to the invention of TAB-seq, a biochemical method that can map 5-hydroxymethylcytosine (5hmC) at base-resolution genome-wide, as well as hmC-Seal, a method...
12 KB (1,145 words) - 06:22, 16 February 2024
Cell potency (redirect from PLETHORA 5)
in primordial germ cells via the initial conversion of 5mC to 5-hydroxymethylcytosine (5hmC), a reaction driven by high levels of the ten-eleven dioxygenase...
30 KB (3,291 words) - 18:55, 18 August 2024
first step in demethylation by converting 5-mC to 5-hydroxymethylcytosine (5-hmC) during embryonic days 9.5 to 10.5. This is likely followed by replication-dependent...
17 KB (2,080 words) - 17:17, 26 April 2024
(TET3) enzyme. TET3 enzyme facilitates conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), initiating active DNA demethylation, an epigenetic...
20 KB (1,481 words) - 20:32, 10 April 2024
"Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine". Science. 339 (6118): 448–52. Bibcode:2013Sci...339..448H. doi:10...
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bases including single base resolution sequencing of 5-formylcytosine, 5-hydroxymethylcytosine and 5-methylcytosine. Honours and awards include: 1998 Glaxo...
19 KB (1,415 words) - 15:53, 19 August 2024
nucleic acid chain has been formed. In DNA, the most common modified base is 5-methylcytosine (m5C). In RNA, there are many modified bases, including those...
15 KB (1,434 words) - 14:39, 12 August 2024
TET enzymes that carry out oxidative reactions (e.g. 5-methylcytosine to 5-hydroxymethylcytosine) and enzymes of the DNA base excision repair (BER) pathway...
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modifications include adenine methylation in bacteria, the presence of 5-hydroxymethylcytosine in the brain, and the glycosylation of uracil to produce the "J-base"...
166 KB (17,865 words) - 08:43, 15 August 2024
systematically demethylated in many organisms, possibly through 5-hydroxymethylcytosine. However, some epigenetic marks, particularly maternal DNA methylation...
88 KB (10,380 words) - 03:17, 13 July 2024
several studies have revealed global decreases in both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) in AD patients compared with controls. However...
30 KB (3,861 words) - 05:37, 12 August 2024
primordial germ cells. The erasure of 5mC occurs via its conversion to 5-hydroxymethylcytosine (5hmC) driven by high levels of the ten-eleven dioxygenase enzymes...
80 KB (7,347 words) - 15:48, 17 August 2024
"Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine". Science. 339 (6118): 448–52. Bibcode:2013Sci...339..448H. doi:10...
10 KB (1,200 words) - 21:54, 3 May 2024
"Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine". Science. 339 (6118): 448–52. Bibcode:2013Sci...339..448H. doi:10...
29 KB (3,162 words) - 03:36, 19 June 2024
"Demethylation of 5-methylcytosine," the first step in active demethylation is a TET oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). The...
42 KB (5,154 words) - 13:37, 14 February 2024
called hMerIP-seq (hydroxymethylcytosine RNA immunoprecipitation), uses an antibody that specifically recognizes 5-hydroxymethylcytosine, a modified RNA...
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13 g/mol, exact mass: 141.0538 u) may refer to: dimetridazole 5-Hydroxymethylcytosine (5hmC) This set index page lists chemical structure articles associated...
298 bytes (57 words) - 19:59, 26 August 2022
"Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine". Science. 339 (6118): 448–52. Bibcode:2013Sci...339..448H. doi:10...
13 KB (1,626 words) - 21:54, 3 May 2024
of the modified DNA base 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC). TET1 produces 5-hmC by oxidation of 5-mC in an iron and alpha-ketoglutarate...
17 KB (1,893 words) - 03:46, 22 January 2024
convert the methylated cytosine on the DNA from 5-methyl cytosine (5mC) into 5-hydroxymethylcytosine (5hmC). This cytosine base then goes through a further...
12 KB (1,565 words) - 18:54, 20 February 2024
Hyaluronate Hyaluronic acid Hyaluronidase Hydrogen peroxide 5-Hydroxymethylcytosine Hydroxyproline 5-Hydroxytryptamine Indigo dye Indole Inosine Inositol Insulin...
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genome encodes 200-300 proteins that are transcribed in operons. 5-Hydroxymethylcytosine may be present in the genome (instead of thymidine). The tubular...
13 KB (1,213 words) - 19:39, 13 June 2024