• Thumbnail for 7-Methylguanine
    7-Methylguanine is a modified purine nucleobase. It is a methylated version of guanine. The 7-methylguanine nucleoside is called 7-methylguanosine. However...
    5 KB (342 words) - 00:05, 3 October 2021
  • Methylguanine may refer to: 1-Methylguanine 2-Methylguanine 3-Methylguanine 6-O-Methylguanine 7-Methylguanine This set index article lists chemical compounds...
    481 bytes (49 words) - 15:29, 25 February 2019
  • Thumbnail for Hepatocyte
    liver cells DNA damages (single-strand breaks, oxidized bases and 7-methylguanine) increase with age. Also, in rat liver, DNA single- and double-strand...
    13 KB (1,584 words) - 08:16, 28 June 2024
  • Thumbnail for Nucleotide base
    in the nucleosides pseudouridine (Ψ), dihydrouridine (D), inosine (I), and 7-methylguanosine (m7G). Hypoxanthine and xanthine are two of the many bases...
    15 KB (1,434 words) - 17:28, 1 July 2024
  • Thumbnail for 6-O-Methylguanine
    6-O-Methylguanine is a derivative of the nucleobase guanine in which a methyl group is attached to the oxygen atom. It base-pairs to thymine rather than...
    7 KB (658 words) - 19:14, 10 April 2024
  • Thumbnail for DNA
    N6-carbamoyl-methyladenine N6-methyadenine Modified Guanine 7-Deazaguanine 7-Methylguanine Modified Cytosine N4-Methylcytosine 5-Carboxylcytosine 5-Formylcytosine...
    166 KB (17,856 words) - 06:29, 24 June 2024
  • Thumbnail for Methylated-DNA-protein-cysteine methyltransferase
    stability. It repairs the naturally occurring mutagenic DNA lesion O6-methylguanine back to guanine and prevents mismatch and errors during DNA replication...
    32 KB (3,856 words) - 07:15, 10 February 2024
  • following chemical reaction Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine...
    3 KB (286 words) - 13:54, 26 August 2023
  • ribonucleate guanine 7-methyltransferase, 7-methylguanine transfer ribonucleate methylase, tRNA guanine 7-methyltransferase, N7-methylguanine methylase, and...
    3 KB (284 words) - 16:07, 26 August 2023
  • Thumbnail for DNA-3-methyladenine glycosylase
    is able to efficiently identify and excise 3-methyladenine, 7-methyladenine, 7-methylguanine, 1N-ethenoadenine and hypoxanthine. Oxanine DNA Glycolase (ODG)...
    24 KB (2,589 words) - 03:18, 19 December 2023
  • mass: 165.15 g/mol, exact mass: 165.0651 u) may refer to: 6-O-Methylguanine 7-Methylguanine This set index page lists chemical structure articles associated...
    282 bytes (58 words) - 19:59, 26 August 2022
  • Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine, and 7-methyladenine Involved in the removal of alkylated bases...
    3 KB (314 words) - 13:54, 26 August 2023
  • Thumbnail for Christopher Chetsanga
    firstly, formamidopyrimidine DNA glycosylase, which removes damaged 7-methylguanine from DNA (1979), and secondly, purine imidazole-ring cyclase, which...
    8 KB (755 words) - 12:49, 30 December 2023
  • 11 identified base modification two, 3-methyladenine (3meA) and O6-methylguanine (O6-meG), are mainly responsible for the biological effects of alkylation...
    10 KB (1,387 words) - 13:30, 5 April 2023
  • Thumbnail for Non-small-cell lung cancer
    P, Hu YC, Doffek K, Sidransky D, Ahrendt SA (November 2001). "O(6)-Methylguanine-DNA methyltransferase promoter hypermethylation shifts the p53 mutational...
    50 KB (5,311 words) - 08:02, 5 June 2024
  • Thumbnail for Neoplasm
    two distinct O6-methylguanine-DNA methyltransferase (O6-MGMT) promoter regions in colorectal cancer". Mol. Biol. Rep. 40 (5): 3851–7. doi:10.1007/s11033-012-2465-3...
    51 KB (5,873 words) - 20:06, 7 June 2024
  • Thumbnail for Matthias Preusser
    tumors. His investigations on the significance of the MGMT gene (O-6-methylguanine-DNA methyltransferase), the IDH gene (glioblastoma multiforme) and the...
    6 KB (583 words) - 19:28, 31 May 2023
  • Thumbnail for Alkylating antineoplastic agent
    found to be limited when in the presence of the DNA-repair enzyme O-6-methylguanine-DNA methyltransferase (MGMT). Cross-linking of double-stranded DNA by...
    13 KB (1,472 words) - 21:10, 8 June 2024
  • Thumbnail for Ethyl methanesulfonate
    stoichiometric fashion by reacting with the active site cysteine of the O-6-methylguanine-DNA methyltransferase repair protein. The in vivo half-life of O6-ethylguanine...
    11 KB (1,014 words) - 16:21, 19 March 2024
  • DNA alkyltransferase, a protein that in humans is encoded by the O6-methylguanine DNA methyltransferase (MGMT) gene. In humans, O6-alkylguanine DNA alkyltransferase...
    3 KB (313 words) - 04:52, 25 December 2022
  • Thumbnail for Cancer cell
    enzyme O-6-methylguanine-DNA methyltransferase is observed in several different kinds of cancer (see Wikipedia article O-6-methylguanine-DNA methyltransferase)...
    16 KB (1,727 words) - 06:01, 19 May 2024
  • Thumbnail for MutS-1
    can also collaborate with methyltransferases in the repair of O(6)-methylguanine damage, which would otherwise pair with thymine during replication to...
    8 KB (900 words) - 00:35, 16 December 2020
  • Thumbnail for Temozolomide
    O6-alkylguanine DNA alkyltransferase (AGT) encoded in humans by the O-6-methylguanine-DNA methyltransferase (MGMT) gene. In some tumors, epigenetic silencing...
    33 KB (2,958 words) - 01:54, 19 April 2024
  • Thumbnail for Cisplatin
    "Preparation and structure of cis-chlorodiammine (N2, N2-dimethyl-9-methylguanine) platinum (II) hexafluorophosphate. A model for the intermediate in...
    39 KB (3,953 words) - 14:30, 19 June 2024
  • Thumbnail for SNAP-tag
    of the ubiquitous mammalian enzyme AGT, encoded in humans by the O-6-methylguanine-DNA methyltransferase (MGMT) gene. SNAP-tag was obtained using a directed...
    9 KB (1,001 words) - 20:35, 13 June 2024
  • Thumbnail for Carcinoma
    Halford S, Rowan A, Sawyer E, Talbot I, Tomlinson I (June 2005). "O(6)-methylguanine methyltransferase in colorectal cancers: detection of mutations, loss...
    30 KB (3,246 words) - 02:33, 23 May 2024
  • Thumbnail for Dacarbazine
    Kewitz S, Stiefel M, Kramm CM, Staege MS (January 2014). "Impact of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and MGMT expression...
    12 KB (1,065 words) - 23:06, 26 January 2024
  • Thumbnail for Douglas Youvan
    Youvan, DC; Hearst, JE (1979). "Reverse transcriptase pauses at N2-methylguanine during in vitro transcription of Escherichia coli 16S ribosomal RNA"...
    4 KB (288 words) - 17:41, 1 June 2024
  • include depurinations, depyrimidinations, double-strand breaks, O6-methylguanines, and cytosine deamination. DNA can be damaged via environmental factors...
    79 KB (9,956 words) - 11:19, 14 March 2024
  • Halford S; Rowan A; Sawyer E; Talbot I; Tomlinson I (June 2005). "O(6)-methylguanine methyltransferase in colorectal cancers: detection of mutations, loss...
    38 KB (4,560 words) - 12:12, 4 April 2024