dehydrogenase type 1 (3α-HSD1), is an enzyme that in humans is encoded by the AKR1C4 gene. It is known to be necessary for the synthesis of the endogenous neurosteroids...
12 KB (1,424 words) - 05:38, 24 August 2024
3α-Hydroxysteroid dehydrogenase (redirect from AKR1C4 (gene))
gene encodes a particular isoform. The most studied isoforms are type 1 (AKR1C4), type 2 (AKR1C3) and type 3 (AKR1C2). Each of these isoforms shares higher...
16 KB (1,731 words) - 18:52, 12 October 2024
5α-DHP is metabolized by the aldo-keto reductases (AKRs) AKR1C1, AKR1C2, and AKR1C4 with high catalytic efficiency. AKR1C1 preferentially forms 20α-hydroxy-5α-pregnane-3-one...
10 KB (909 words) - 23:12, 9 November 2023
via 3α-reduction by a 3α-hydroxysteroid dehydrogenase isozyme (AKR1C2 and AKR1C4) or HSD17B6, that also has 3α-reduction activity. The pathway then proceeds...
79 KB (8,735 words) - 07:29, 14 October 2024
includes the AKR1C and AKR1D subgroups, which respectively consist of AKR1C1–AKR1C4 and AKR1D1. Together with short-chain dehydrogenase/reductases (SDRs), these...
2 KB (161 words) - 18:17, 17 December 2020
HGNC:384 Q04828 521 AKR1C2 HGNC:385 P52895 522 AKR1C3 HGNC:386 P42330 523 AKR1C4 HGNC:387 P17516 524 AKR1C8 HGNC:23469 Q5T2L2 525 AKR1D1 HGNC:388 P51857...
277 KB (17 words) - 18:34, 6 October 2024
PMID 11158055. human types 1 and 3 3α-HSD, 20α-HSD, and type 5 17β-HSD were named AKR1C4, AKR1C2, AKR1C1, and AKR1C3, respectively Human AKR1C3 genome location and...
12 KB (1,513 words) - 03:23, 2 November 2024
dehydrogenase (3α-HSD), i.e. by the two aldo-keto reductase isozymes: AKR1C2 and AKR1C4, and by 17β-hydroxysteroid dehydrogenase 6 (HSD17B6) that also has the 3α-HSD...
14 KB (1,217 words) - 08:11, 20 August 2024
Cao J, He QJ, Zhu H, Yang B (14 March 2017). "Aldo-Keto Reductase AKR1C1-AKR1C4: Functions, Regulation, and Intervention for Anti-cancer Therapy". Front...
8 KB (1,053 words) - 03:42, 12 August 2024
PMID 11158055. human types 1 and 3 3α-HSD, 20α-HSD, and type 5 17β-HSD were named AKR1C4, AKR1C2, AKR1C1, and AKR1C3, respectively 3α-Hydroxysteroid dehydrogenase...
9 KB (1,146 words) - 15:16, 12 May 2024
Turosteride • Vitamin B6 • Zinc 3α-HSDTooltip 3α-Hydroxysteroid dehydrogenase (AKR1C4) 5α-Dihydroprogesterone↔Allopregnanolone • DHDOC↔THDOC •...
37 KB (2,107 words) - 21:47, 24 November 2024
of fetal androgen synthesis involving aldo-keto reductases (AKR1C2 and AKR1C4), showing that both the conventional and alternative ("backdoor") pathways...
19 KB (1,915 words) - 17:15, 31 May 2024