N-Acetylserotonin O-methyltransferase, also known as ASMT, is an enzyme which catalyzes the final reaction in melatonin biosynthesis: converting Normelatonin...
20 KB (2,283 words) - 23:26, 28 November 2023
Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is one of several enzymes that degrade catecholamines (neurotransmitters such as dopamine, epinephrine...
29 KB (3,236 words) - 00:14, 10 July 2024
An O-methyltransferase (OMT) is a type of methyltransferase enzyme transferring a methyl group on a molecule. Examples are : Acetylserotonin O-methyltransferase...
3 KB (254 words) - 20:21, 22 July 2022
N-acetylserotonin O-methyltransferase-like protein is an enzyme that in humans is encoded by the ASMTL gene. GRCh38: Ensembl release 89: ENSG00000169093...
3 KB (260 words) - 00:07, 5 September 2022
a treatment for myelodysplastic syndrome in its capacity as a DNA methyltransferase inhibitor. "Prescription medicines: registration of new generic medicines...
16 KB (1,332 words) - 03:59, 30 September 2024
deficits associated with schizophrenia: potential role of catechol-O-methyltransferase inhibitors". CNS Drugs. 21 (7): 535–557. doi:10.2165/00023210-200721070-00002...
28 KB (2,798 words) - 01:21, 21 November 2024
transferase Substrates→Products: Serotonin→N-Acetylserotonin ASMTTooltip Acetylserotonin O-methyltransferase Substrates→Products: N-Acetylserotonin→Melatonin...
9 KB (588 words) - 05:37, 31 October 2024
N-acetyltransferase (AANAT) and is converted to melatonin by acetylserotonin O-methyltransferase (ASMT). NAS is able to penetrate the blood–brain barrier...
12 KB (1,142 words) - 10:25, 21 October 2024
the protozoan's cell membrane. It is known to act as a histamine N-methyltransferase inhibitor. It also inhibits NF-κB and activates p53. Mepacrine was...
14 KB (1,455 words) - 16:11, 7 August 2024
The drug has also been found to act as an inhibitor of histamine N-methyltransferase (HNMT). Oral bioavailability of diphenhydramine is in the range of...
69 KB (6,256 words) - 00:09, 15 November 2024
transferase Substrates→Products: Serotonin→N-Acetylserotonin ASMTTooltip Acetylserotonin O-methyltransferase Substrates→Products: N-Acetylserotonin→Melatonin...
7 KB (553 words) - 19:38, 8 September 2024
Cook IA, Alpert JE (August 2009). "Monoamine oxidase a and catechol-o-methyltransferase functional polymorphisms and the placebo response in major depressive...
40 KB (4,637 words) - 01:01, 4 November 2024
N-acetylserotonin. N-acetylserotonin is converted into melatonin by the enzyme hydroxyindole O-methyltransferase (HIOMT), also known as acetylserotonin...
13 KB (1,516 words) - 17:04, 22 February 2024
transferase Substrates→Products: Serotonin→N-Acetylserotonin ASMTTooltip Acetylserotonin O-methyltransferase Substrates→Products: N-Acetylserotonin→Melatonin...
14 KB (1,085 words) - 07:35, 8 October 2024
Phenylethanolamine N-methyltransferase (PNMT) is an enzyme found primarily in the adrenal medulla that converts norepinephrine (noradrenaline) to epinephrine...
16 KB (1,894 words) - 10:01, 27 March 2024
a Fe(II)-O-O-BH4 bridge. heterolytic cleavage of the O-O bond to yield the ferryl oxo hydroxylating intermediate Fe(IV)=O attack on Fe(IV)=O to hydroxylate...
31 KB (3,687 words) - 05:50, 12 August 2024
transferase Substrates→Products: Serotonin→N-Acetylserotonin ASMTTooltip Acetylserotonin O-methyltransferase Substrates→Products: N-Acetylserotonin→Melatonin...
14 KB (1,526 words) - 03:35, 8 September 2024
Nitecapone (category Catechol-O-methyltransferase inhibitors)
enzyme catechol O-methyl transferase (COMT). It was patented as an antiparkinson medication but was never marketed. Catechol-O-methyltransferase inhibitor F...
2 KB (107 words) - 09:30, 8 October 2024
transferase Substrates→Products: Serotonin→N-Acetylserotonin ASMTTooltip Acetylserotonin O-methyltransferase Substrates→Products: N-Acetylserotonin→Melatonin...
47 KB (5,008 words) - 04:15, 20 October 2024
Neuroscience. 15. doi:10.3389/fnmol.2022.925272. PMC 9271706. PMID 35832393. Janiger O, De Rios MD (March 25, 1976). "Nicotiana an Hallucinogen?". Economic Botany...
103 KB (10,986 words) - 06:41, 16 September 2024
transferase Substrates→Products: Serotonin→N-Acetylserotonin ASMTTooltip Acetylserotonin O-methyltransferase Substrates→Products: N-Acetylserotonin→Melatonin...
32 KB (3,294 words) - 16:16, 23 September 2024
substituted tryptamine serotonergic agents like dimethyltryptamine (DMT), 5-MeO-DMT, bufotenin, almotriptan, rizatriptan, and sumatriptan, and other compounds...
39 KB (4,124 words) - 11:34, 2 November 2024
at the University of Sydney in 1949. It also acts as a histamine N-methyltransferase inhibitor. Tacrine was the prototypical cholinesterase inhibitor for...
9 KB (723 words) - 16:44, 12 July 2024
transferase Substrates→Products: Serotonin→N-Acetylserotonin ASMTTooltip Acetylserotonin O-methyltransferase Substrates→Products: N-Acetylserotonin→Melatonin...
7 KB (517 words) - 21:14, 17 October 2024
Zivanović O, Till E (1992). "[Serotonin syndrome--a case account]". Medicinski Pregled. 45 (3–4): 116–118. PMID 16104086. Spigset O, Mjörndal T, Lövheim O (January...
83 KB (9,142 words) - 14:24, 11 November 2024
transferase Substrates→Products: Serotonin→N-Acetylserotonin ASMTTooltip Acetylserotonin O-methyltransferase Substrates→Products: N-Acetylserotonin→Melatonin...
8 KB (574 words) - 12:48, 18 September 2024
transferase Substrates→Products: Serotonin→N-Acetylserotonin ASMTTooltip Acetylserotonin O-methyltransferase Substrates→Products: N-Acetylserotonin→Melatonin...
11 KB (1,122 words) - 23:12, 28 October 2024
doi:10.1038/sj.bjp.0705962. PMC 1575354. PMID 15339864. Weinreb O, Amit T, Bar-Am O, Youdim MB (November 2010). "Rasagiline: a novel anti-Parkinsonian...
90 KB (8,916 words) - 04:53, 12 November 2024
transferase Substrates→Products: Serotonin→N-Acetylserotonin ASMTTooltip Acetylserotonin O-methyltransferase Substrates→Products: N-Acetylserotonin→Melatonin...
5 KB (324 words) - 19:40, 8 September 2024
Opicapone (category Catechol-O-methyltransferase inhibitors)
levodopa in people with Parkinson's disease. Opicapone is a catechol-O-methyltransferase (COMT) inhibitor. The most common side effects are dyskinesia (difficulty...
33 KB (1,832 words) - 09:29, 8 October 2024