In eukaryotic cells, an aggresome refers to an aggregation of misfolded proteins in the cell, formed when the protein degradation system of the cell is...

were shortened by mutations. Lewy bodies are believed to represent an aggresome response in the cell. When misfolded proteins aggregate, or clump together...

some are not. Note the following four examples: HDAC6 is associated with aggresomes. Misfolded protein aggregates are tagged by ubiquitination and removed...

rely on cholesteryl esters derived from LDL. Vimentin plays a role in aggresome formation, where it forms a cage surrounding a core of aggregated protein...

"The cellular fate of mutant rhodopsin: quality control, degradation and aggresome formation". Journal of Cell Science. 115 (Pt 14): 2907–2918. doi:10.1242/jcs...

viral factories of the ASFV viroplasm is very similar to the aggresome formation. An aggresome is a perinuclear site where misfolded proteins are transported...

overworked. In mammalian cells, these protein aggregates are termed "aggresomes" and they are formed when the cell is diseased. This is because aggregates...

reticulum stress response (ER stress) Mitochondrial unfolded protein response Aggresome PERK inhibitors Hetz C, Papa FR (January 2018). "The Unfolded Protein...

endosome PML body late endosome P-body phagophore assembly site nucleoplasm aggresome autophagosome amphisome endoplasmic reticulum inclusion body lysosome...

perinuclear region of cytoplasm nucleus Lewy body SCF ubiquitin ligase complex aggresome endoplasmic reticulum Golgi apparatus Parkin-FBXW7-Cul1 ubiquitin ligase...

bodies in neurodegenerative diseases are aggregates of misfolded proteins (aggresomes) and are hallmarks of many of these diseases, including Lewy bodies in...

efficacy of mammalian cells may be limited by epigenetic gene silencing and aggresome formation (recombinant protein aggregation). For mammalian cells, synthesised...

function proteasome binding protein binding Cellular component cytoplasm aggresome nucleus fibrillar center cytosol Biological process positive regulation...

nucleus kinetochore centrosome rough endoplasmic reticulum dendritic shaft aggresome cell surface membrane-bounded organelle endoplasmic reticulum membrane...

membrane membrane intracellular membrane-bounded organelle plasma membrane aggresome ciliary membrane clathrin-coated pit AP-2 adaptor complex clathrin-coated...

novo purine biosynthesis. However, nocodazole also blocks formation of aggresomes, complicating interpretation of these observations. Partial inhibition...

autophagy in macrophages is a p62-dependent type of selective autophagy of aggresome-like induced structures (ALIS). Autophagy, 7: 29–31. Fujita K, Xiao Q...

binding Cellular component cytoplasm cytosol endosome membrane nucleoplasm aggresome Biological process phosphorylation positive regulation of interferon-alpha...

ubiquitin-dependent protein catabolic process protein hexamerization aggresome assembly flavin adenine dinucleotide catabolic process proteasome-mediated...

clathrin-coated vesicle cytoplasm cytoplasmic vesicle nucleus cytosol nucleoplasm aggresome lateral plasma membrane nuclear body Biological process non-canonical...

component cytosol ESC/E(Z) complex intracellular anatomical structure aggresome perinuclear region of cytoplasm peroxisome cytoplasm Biological process...

ATPase activity helicase activity hydrolase activity Cellular component aggresome nucleus nucleoplasm cytosol site of DNA damage chromosome Biological process...

component transcription repressor complex nucleus nucleoplasm cytosol aggresome cytoplasm Biological process positive regulation of brown fat cell differentiation...

nucleus multivesicular body cell projection microtubule associated complex aggresome dynein complex histone deacetylase complex perikaryon axon inclusion body...

binding Cellular component cytoplasm polysome membrane plasma membrane aggresome membrane raft extracellular exosome nucleus polysomal ribosome extracellular...

follicular lymphoma in apparently healthy individuals, and of dendritic cell aggresome-like induced structures (DALIS) in dendritic cells, thought to play an...

3'-5'-exoribonuclease activity RNA binding Cellular component membrane aggresome nucleolus nucleus nucleoplasm Biological process RNA processing regulation...

membrane focal adhesion plasma membrane sarcoplasmic reticulum nucleoplasm aggresome cell junction myofibril Z discdkac meiotic nuclear membrane microtubule...

region cytoskeleton nucleus kinetochore axon cytoplasm cytoplasm cytosol aggresome perinuclear region of cytoplasm nuclear envelope nucleoplasm spindle nuclear...

neuron projection cytoskeleton presynaptic membrane mitochondrion cytosol aggresome synaptic vesicle trans-Golgi network membrane postsynaptic early endosome...