Allotopic expression (AE) refers to expression of genes in the cell nucleus that normally are expressed only from the mitochondrial genome. Biomedically...

as a possible treatment for inherited mitochondrial disease, and allotopic expression of mitochondrial proteins as a radical treatment for mtDNA mutation...

has been suggested that inteins could prove useful for achieving allotopic expression of certain highly hydrophobic proteins normally encoded by the mitochondrial...

2020-12-31. Boominathan, Amutha; et al. (2016-09-04). "Stable nuclear expression of ATP8 and ATP6 genes rescues a mtDNA Complex V null mutant". Nucleic...

Intracellular aggregates Novel lysosomal hydrolases Mitochondrial mutations Allotopic expression of 13 proteins Cancerous cells Removal of telomere-lengthening machinery...

Research Foundation have published a paper detailing the successful allotopic expression of replacement DNA for the MT-ATP6 gene in the cell nuclear DNA....

stem cells and tissue engineering, telomere-lengthening machinery, allotopic expression of mitochondrial proteins, targeted ablation of cells, immunotherapeutic...

these genes are present only in the mitochondria and are unable to be allotopically expressed. This is significant for the testing and development of therapies...