An autophagosome is a spherical structure with double layer membranes. It is the key structure in macroautophagy, the intracellular degradation system...

from the rest of the cell within a double-membrane vesicle known as an autophagosome, which, in time, fuses with an available lysosome, bringing its specialty...

in autophagy substrate selection and autophagosome biogenesis. LC3 is the most widely used marker of autophagosomes. LC3 was originally identified as a...

(PAMPs or DAMPs), the removal of senescent cells is non-inflammatory. Autophagosomes are different from phagosomes in that they are mainly used to selectively...

sequester portions of the cytosol, the so-called autophagosomes. The outer membrane of these autophagosomes subsequently fuses with the lysosome/vacuole to...

phagophore and eventually become the contents of the fully assembled autophagosome. Autophagosome biogenesis requires the initiation and growth of phagophores...

signal transduction amplifiers. Recently, σ1R has been implicated in autophagosome formation and maturation. Autophagy is a broad homeostatic, metabolic...

with the disruption of autophagic flux via inhibiting the fusion of autophagosomes and lysosomes". Toxicology Letters. 321: 32–43. doi:10.1016/j.toxlet...

chaperone-associated ubiquitin ligases. The ubiquitinated proteins are enclosed in autophagosomes, which eventually fuse with lysosomes, leading to the degradation of...

section of the cytoplasm, generating the autophagosome, a distinctive double-membraned organelle. The autophagosome then joins the lysosome to create an autolysosome...

EMC6 interacts with the small GTPase RAB5A and Beclin-1, regulators of autophagosome formation. This observation suggests that the mEMC, and not just EMC6...

becoming LC3-II. After formation of the autophagosome, the ATG12-ATG5:ATG16L complex dissociates from the autophagosome. In instances of spontaneous apoptosis...

(ATG8) lipidation and autophagosome formation. This complex localizes to the membrane and is released just before or after autophagosome completion. Furthermore...

"Ultrastructural analysis of the autophagic process in yeast: detection of autophagosomes and their characterization". Journal of Cell Biology. 124 (6): 903–913...

and will bind to BCL2 in the outer membrane. This relocation enables autophagosome nucleation. AMBRA1 protein is involved in several cellular processes...

by encapsulating them into an autophagosome, which fuses with a lysosome to destroy the contents of the autophagosome. Because many neurodegenerative...

structures that mature into autophagosomes, and fuse with lysosomes in order to degrade the contents of the autophagosomes. The formation of omegasomes...

It is part of the ULK1-complex, which is needed in early steps of autophagosome biogenesis. The ULK1 complex also consists of the FAK family kinase...

into autophagosomes, and effects on autophagosome-lysosome fusion. Atg8ylation is important for ESCRT-dependent sealing of nascent autophagosomes and for...

have shown that Berkeley bodies share structural similarities with autophagosomes, which are involved in autophagy. The organelle consists of two enclosed...

encoded by the gene ATG1. It is essential for the initial building of the autophagosome and Cvt vesicles. In a non-kinase role it is - through complex formation...

action through interaction with the small GTPase Rab7, and impairs the autophagosome-lysosome fusion step of autophagy through inhibition of PI3KC3-C2 (class...

Research by Wang et al finds that infected cells lead to higher levels of autophagosomes in normal and infected cells. Their research reveals that T. gondii...

chromosome, centromeric region protein-containing complex autophagosome membrane autophagosome cytoplasmic vesicle Biological process double-strand break...

peroxisome; vacuole; cytoplasmic granules; cell vesicles (phagosome, autophagosome, clathrin-coated vesicles, COPI-coated and COPII-coated vesicles) and...

GABARAP has an important function in autophagosome mediated autophagy, since it is crucial for autophagosome formation and sequestration of cytosolic...

tcb.2007.07.009. PMID 17804237. Xie Z, Klionsky DJ (October 2007). "Autophagosome formation: core machinery and adaptations". Nature Cell Biology. 9 (10):...

membrane, especially phosphatidylserine. GRAMD1A also is necessary for autophagosome biogenesis. GRCh38: Ensembl release 89: ENSG00000089351 – Ensembl, May...

clathrin-coated vesicle membrane Biological process positive regulation of autophagosome maturation adenylate cyclase-activating G protein-coupled receptor signaling...

2008). "The N-terminus and Phe52 residue of LC3 recruit p62/SQSTM1 into autophagosomes". J. Cell Sci. 121 (Pt 16): 2685–95. doi:10.1242/jcs.026005. PMID 18653543...