C-C chemokine receptor type 5, also known as CCR5 or CD195, is a protein on the surface of white blood cells that is involved in the immune system as it...

CCR5 receptor antagonists are a class of small molecules that antagonize the CCR5 receptor. The C-C motif chemokine receptor CCR5 is involved in the process...

making the body more susceptible to other infections. CCR5-Δ32 is an allelic variant of CCR5 gene with a 32 base pair deletion that results in a truncated...

that causes AIDS. The main mechanism is a mutation of the gene encoding CCR5, which acts as a co-receptor for HIV. It is estimated that the proportion...

technology for modifying DNA. The embryos' genomes were edited to remove the CCR5 gene in an attempt to confer genetic resistance to HIV. The clinical project...

gp120 which blocks binding and infection of viral strains which use the CCR5 receptor to infect cells. Peptide T has several positive effects related...

(codenamed PRO 140) is a humanized monoclonal antibody targeted against the CCR5 receptor found on T lymphocytes of the human immune system. It is being investigated...

genetics, it can stand for a gene deletion (e.g. the CCR5-Δ32, a 32 nucleotide/bp deletion within CCR5). The American Dental Association cites it (together...

or non-syncitia-inducing strains (NSI) use the beta-chemokine receptor CCR5 for entry and are thus able to replicate in macrophages and CD4+ T-cells...

medication used to treat HIV infection. It is taken by mouth. It is in the CCR5 receptor antagonist class. It was approved for medical use in the United...

use the β-chemokine receptor, CCR5, for entry and are thus able to replicate in both macrophages and CD4+ T cells. This CCR5 co-receptor is used by almost...

CC chemokines CCL3, CCL5, CCL17 and CCL22 signal through this receptor. CCR5 is expressed on several cell types including peripheral blood-derived dendritic...

CRISPR/Cas9 gene-editing, they introduced a natural mutation CCR5-Δ32 in gene called CCR5, which would confer resistance to M-tropic HIV infection. The...

Vicriviroc, previously named SCH 417690 and SCH-D, is a pyrimidine CCR5 entry inhibitor of HIV-1. It was developed by the pharmaceutical company Schering-Plough...

CCR4 and CCR5, belonging to seven transmembrane G-protein coupled receptor (GPCRs) family, it has the highest affinity to the CCR5. CCR5 is presented...

targeted deletions, the custom ZFN disables the C-C chemokine receptor 5 (CCR5) gene, which encodes a co-receptor that is used by the HIV virus to enter...

co-receptor along with the CD4-gp120 complex to enter the target cells - either CCR5 or CXCR4. This demonstrates an example of how cell surface receptors can...

Germany, including Gero Hütter). From 60 matching donors, they selected a [CCR5]-Δ32 homozygous donor, an individual with two genetic copies of a rare variant...

that alters the CCR5 protein when present in both chromosomes very effectively prevents HIV-1 infection. HIV seeks out and destroys CCR5 expressing CD4+...

given weaker immunosuppressive drugs. The selected donor also carried the CCR5-Δ32 mutation. The first Berlin patient was described in 1998. After receiving...

CCR5-Δ32 mutation in both genomic copies of a gene encoding a cell-surface chemokine receptor called CCR5. Because "most of HIV strains" use the CCR5...

CD4+ T cells gp120, a protein on HIV surface that binds to the CD4 receptor CCR5, a second receptor found on the surface of CD4+ cells and macrophages, called...

surface express several receptors for chemokines: CCR1, CCR2, CCR3, CCR4, CCR5, CXCR2, and CXCR4. Ligands of these receptors CCL2 and CCL5 play an important...

characterized the CCR5 GPCR and discovered its role as a co-receptor in HIV infection. Cedric Blanpain earned his PhD in 2001 for his work on CCR5 and HIV infection...

Crohn, for whom Crohn's disease is named. Crohn had the Δ32 mutation on the CCR5 receptor, a protein on the surface of white blood cells that is involved...

and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of...

both CCR5 and CXCR4 tropic HIV viruses. In rare cases, individuals may have a mutation in the CCR5 delta gene which results in a nonfunctional CCR5 co-receptor...

despite high levels of circulating virus. Regulation of the activity of the CCR5 coreceptor is one of the natural strategies to avoid disease in some natural...

population possess a mutation, called CCR5-Δ32 (frequency of 0.0808 for homozygous allele), that prevents the CCR5 chemokine receptor protein, which is...

the gene CCR5 gives some protection against HIV but leads to more serious complications of WNV infection. Carriers of two mutated copies of CCR5 made up...