CYP2R1 is cytochrome P450 2R1, an enzyme which is the principal vitamin D 25-hydroxylase. In humans it is encoded by the CYP2R1 gene located on chromosome...
9 KB (1,133 words) - 14:06, 24 January 2024
This enzymatic 25-hydroxylase reaction is mostly due to the actions of CYP2R1, present in microsomes, although other enzymes such as mitochondrial CYP27A1...
20 KB (1,953 words) - 16:13, 26 April 2024
become active and bind to the VDR. Specifically, CYP27A1, CYP27B1, and CYP2R1 are involved in the activation of vitamin D, while CYP24A1 and CYP3A4 are...
68 KB (7,912 words) - 17:56, 20 August 2024
requires two hydroxylations to become active: the first in the liver by CYP2R1 to form 25-hydroxyergocalciferol (ercalcidiol or 25-OH D2), and the second...
24 KB (1,969 words) - 17:42, 3 August 2024
become active and bind to the VDR. Specifically, CYP27A1, CYP27B1, and CYP2R1 are involved in the activation of vitamin D, while CYP24A1 and CYP3A4 are...
162 KB (17,765 words) - 17:56, 20 August 2024
converted to its active form by two hydroxylations: the first in the liver, by CYP2R1 or CYP27A1, to form 25-hydroxycholecalciferol (calcifediol, 25-OH vitamin...
41 KB (4,143 words) - 05:59, 12 August 2024
HGNC:2631 P05181 3886 CYP2F1 HGNC:2632 P24903 3887 CYP2J2 HGNC:2634 P51589 3888 CYP2R1 HGNC:20580 Q6VVX0 3889 CYP2S1 HGNC:15654 Q96SQ9 3890 CYP2U1 HGNC:20582 Q7Z449...
277 KB (17 words) - 23:17, 27 April 2024
activation VDDR1A: 25-Hydroxyvitamin D3 1-alpha-hydroxylase deficiency VDDR1B: CYP2R1 deficiency Type 2: resistance to calcitriol VDDR2A: calcitriol receptor...
46 KB (4,731 words) - 15:34, 11 August 2024
CYP2B6, CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP2R1, CYP2S1, CYP2U1, CYP2W1 Too many to list CYP3 drug and steroid (including...
42 KB (4,485 words) - 22:27, 17 July 2024
608611; RPIA Rickets due to defect in vitamin D 25-hydroxylation; 600081; CYP2R1 Rickets, vitamin D-resistant, type IIA; 277440; VDR RIDDLE syndrome; 611943;...
234 KB (18,877 words) - 15:43, 9 May 2024