family 3, subfamily A, also known as CYP3A, is a human gene locus. A homologous locus is found in mice. The CYP3A locus includes all the known members...

removed from the body. It is highly homologous to CYP3A5, another important CYP3A enzyme. While many drugs are deactivated by CYP3A4, there are also some...

Nirmatrelvir inhibits SARS-CoV-2 main protease, while ritonavir is a strong CYP3A inhibitor, slowing down nirmatrelvir metabolism and therefore boosting its...

that strongly inhibit CYP3A, nor with drugs that activate CYP3A, such as rifampin and phenobarbital. For drugs that are moderate CYP3A inhibitors, such as...

cytochrome P450 system, in particular, by isozymes of the CYP3A superfamily. The activity of the CYP3A enzymes can be induced or inhibited by certain drugs...

elvitegravir levels by inhibiting CYP3A.) Furthermore, elvitegravir is a weak to medium inducer of CYP1A2, CYP2C19, CYP2C9, CYP3A, and a number of UGTs; the...

(HIV/AIDS). Its major mechanism of action is through the inhibition of human CYP3A proteins.[non-primary source needed] Like ritonavir (Norvir), cobicistat...

plasma proteins. The substance is metabolized in the liver, mainly via CYP3A, and in the intestinal wall. All metabolites found in the circulation are...

Products Administration (NMPA) for COVID-19. The use of ritonavir as a CYP3A inhibitor is also seen in the Hepatitis C medication ombitasvir/paritaprevir/ritonavir...

Zhang L, Kleine-Brueggeney M, Fimmers R, et al. (July 2011). "CYP2D6- and CYP3A-dependent enantioselective plasma concentrations of ondansetron in postanesthesia...

prolongation and TdP. Erythromycin works inhibiting the CYP3A protein. Patients who have low CYP3A activity and are also concurrently taking other medications...

effectively than a placebo. Concomitant use of suzetrigine with strong CYP3A inhibitors is contraindicated. Common adverse effects of suzetrigine may...

"Application of PBPK modeling to predict human intestinal metabolism of CYP3A substrates – An evaluation and case study using GastroPlus™". European Journal...

(February 2013). "Metabolic pathways of inhaled glucocorticoids by the CYP3A enzymes". Drug Metabolism and Disposition. 41 (2): 379–389. doi:10.1124/dmd...

in August 2001 due to risk of serious rhabdomyolysis) Synthetic various CYP3A isoforms Fluvastatin Lescol, Lescol XL, Lipaxan, Primesin Synthetic CYP2C9...

ERMBT has been widely used and verified as a reliable method for measuring CYP3A activity in real time. Its non-invasive nature makes it useful for researching...

interactions with clementines: Two single case experiments show no effect on CYP3A-dependent midazolam clearance". European Journal of Pharmaceutical Sciences...

interruptive and inhibitory effects of CO varies upon different CYPs such that the CYP3A family is relatively less affected. Biology portal Cytochrome P450 oxidoreductase...

Hall SD (February 2003). "Droperidol is predominantly metabolized by human CYP3A enzymes". Clinical Pharmacology & Therapeutics. 73 (2): P16. doi:10...

more toxic forms. Among Phase I CYP450 enzymes, the subfamilies CYP2D6 and CYP3A are responsible for hepatotoxicity during drug metabolism with a number...

because they contain CYP3A inhibitors. Additionally, while using venetoclax it is not recommended to use other drugs which contain CYP3A inhibitors (i.e.:...

the effectiveness of perampanel by 50-67%. Use of perampanel with strong CYP3A inducers like rifampin or St. John's wort is not recommended. Use of perampanel...

vitro: can dextromethorphan be used as a dual probe for both CTP2D6 and CYP3A activities?". Drug Metabolism and Disposition. 29 (11): 1514–20. PMID 11602530...

CYP2C19, an inhibitor of CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A, and an inducer of CYP1A2 and CYP3A4. A literature survey reveals very few...

vitro: can dextromethorphan be used as a dual probe for both CTP2D6 and CYP3A activities?". Drug Metabolism and Disposition. 29 (11): 1514–1520. PMID 11602530...

enzymes CYP2C19, CYP1A2, and CYP2B6, then by CYP2C19, CYP2C9, CYP2B6, and CYP3A. The thiophene ring is converted to a thiolactone, which undergoes ring-opening...

"Ethylmorphine N-demethylase activity as a marker for cytochrome P450 CYP3A activity in rat hepatic microsomes". Toxicology Letters. 94 (2): 115–25...

52.5-kD protein, whereas CYP3A4 migrates as a 52.0-kD protein. The human CYP3A subfamily, CYP3A4, CYP3A5, CYP3A7 and CYP3A43, is one of the most versatile...

Friedl's Blog "Inhibitory effects of citrus fruits on cytochrome P450 3A (CYP3A) activity in humans" "Production of Haploid Plant of 'Banpeiyu' Pummelo...

2010). "Genetic polymorphisms and drug interactions modulating CYP2D6 and CYP3A activities have a major effect on oxycodone analgesic efficacy and safety"...