• Thumbnail for Citrullination
    Citrullination or deimination is the conversion of the amino acid arginine in a protein into the amino acid citrulline. Citrulline is not one of the 20...
    17 KB (1,968 words) - 02:47, 27 October 2024
  • Thumbnail for Anti–citrullinated protein antibody
    citrulline residues in proteins such as vimentin, by a process called citrullination. If their shapes are significantly altered, the proteins may be seen...
    16 KB (1,806 words) - 02:53, 9 November 2024
  • Thumbnail for Histone-modifying enzymes
    modifications including O-GlcNAcylation, sumoylation, ADP-ribosylation, citrullination and proline isomerization. For a detailed example of histone modifications...
    33 KB (3,157 words) - 04:31, 13 August 2024
  • Thumbnail for Citrulline
    (PADs), which convert arginine into citrulline in a process called citrullination or deimination with the help of calcium ions. Proteins that normally...
    11 KB (856 words) - 14:42, 29 July 2024
  • Thumbnail for Histone
    in their globular domains. Such modifications include methylation, citrullination, acetylation, phosphorylation, SUMOylation, ubiquitination, and ADP-ribosylation...
    84 KB (9,582 words) - 18:07, 20 August 2024
  • Thumbnail for Myelin basic protein
    protein, which include phosphorylation, methylation, deamidation, and citrullination. These forms differ by the presence or the absence of short (10 to 20...
    25 KB (2,983 words) - 23:11, 17 August 2024
  • symptoms often are lacking but when medical therapy is most effective. Citrullination is a modification of proteins where a nitrogen in the amino acid arginine...
    6 KB (666 words) - 19:29, 3 December 2023
  • Thumbnail for Arginine
    form citrulline, in a post-translational modification process called citrullination.This is important in fetal development, is part of the normal immune...
    32 KB (3,143 words) - 14:17, 19 October 2024
  • contains the enzyme peptidyl-arginine deiminase, which is involved in citrullination. Patients with rheumatoid arthritis have increased incidence of periodontal...
    34 KB (3,916 words) - 01:18, 23 July 2024
  • Thumbnail for Rheumatoid arthritis
    associated with periodontitis are implicated as mediators of protein citrullination in the gums of people with RA. Vitamin D deficiency is more common in...
    149 KB (16,153 words) - 04:13, 11 November 2024
  • Thumbnail for Epigenetics
    methylation, ubiquitylation, phosphorylation, sumoylation, ribosylation and citrullination. Acetylation is the most highly studied of these modifications. For...
    161 KB (18,406 words) - 14:37, 21 November 2024
  • Carbamylation Succinylation Lactylation Propionylation Butyrylation Arginine Citrullination Methylation ADP-ribosylation Proline Hydroxylation Histidine Diphthamide...
    11 KB (1,074 words) - 21:50, 5 May 2024
  • Thumbnail for Post-translational modification
    pupylation, the covalent linkage to the prokaryotic ubiquitin-like protein citrullination, or deimination, the conversion of arginine to citrulline deamidation...
    32 KB (3,131 words) - 03:19, 21 November 2024
  • disease rheumatoid arthritis due to its ability to stimulate protein citrullination, a post-translational protein modification targeted by autoantibodies...
    9 KB (904 words) - 02:40, 30 August 2024
  • Citrullinated protein may refer to: Any protein having undergone citrullination The proteins (often cyclic ones) being the targets of anti-citrullinated...
    240 bytes (55 words) - 12:53, 3 March 2011
  • Thumbnail for Leo van de Putte
    1999. ISBN 90-6984-249-1. Vossenaar, E; Robinson, W (2005-10-01). "Citrullination and auto-immune disease: 8th Bertine Koperberg meeting". Annals of the...
    15 KB (1,636 words) - 14:46, 16 November 2024
  • Thumbnail for Autoimmunity
    incidence and severity of rheumatoid arthritis. This may relate to abnormal citrullination of proteins, since the effects of smoking correlate with the presence...
    51 KB (5,880 words) - 19:29, 16 November 2024
  • Thumbnail for Neutrophil extracellular traps
    reactive oxygen species (ROS) intermediaries. PAD4 is responsible for the citrullination of histones in the neutrophil, resulting in decondensation of chromatin...
    29 KB (3,352 words) - 06:33, 19 October 2024
  • Thumbnail for Protein-arginine deiminase
    of post translational modification called arginine de-imination or citrullination: protein L-arginine + H2O ⇌ {\displaystyle \rightleftharpoons } protein...
    4 KB (309 words) - 17:17, 3 December 2023
  • (such as methylation, acetylation, ADP-ribosylation, ubiquitination, citrullination, SUMO-ylation and phosphorylation) to histone tails alter chromatin...
    16 KB (1,689 words) - 22:30, 1 April 2024
  • Thumbnail for PADI4
    responsible for the conversion of arginine to citrulline residues (citrullination). This gene may play a role in granulocyte and macrophage development...
    11 KB (1,214 words) - 11:48, 10 October 2024
  • Thumbnail for Phenylglyoxal
    citrulline: development of a phenylglyoxal-based probe to visualize protein citrullination". J Am Chem Soc. 134 (41): 17015–8. doi:10.1021/ja308871v. PMC 3572846...
    5 KB (351 words) - 07:14, 27 December 2021
  • histone H3 citrullination contributes to demyelination, research demonstrates that inhibitors of the enzymes involved in this citrullination improve the...
    59 KB (7,834 words) - 20:36, 29 September 2024
  • Lüthke K, Rudolph PE, Fredenhagen G, et al. (2007). "Mutation and citrullination modifies vimentin to a novel autoantigen for rheumatoid arthritis"....
    49 KB (6,121 words) - 10:43, 15 November 2024
  • Thumbnail for Lars Klareskog
    (shared epitope) -restricted immune reactions to autoantigens modified by citrullination . In: Arthritis & Rheumatism , Volume 54, January 2006, pp. 38-46. doi:10...
    5 KB (587 words) - 16:26, 26 November 2023
  • Spectrometry-Based Method for Simultaneous Qualitative and Quantitative Protein Citrullination Analysis of Complex Biological Samples (2020) US 20210181206 A1 Phillips...
    9 KB (791 words) - 00:39, 24 August 2024
  • Thumbnail for PADI2
    "Proteomics implicates peptidyl arginine deiminase 2 and optic nerve citrullination in glaucoma pathogenesis". Invest. Ophthalmol. Vis. Sci. 47 (6): 2508–14...
    6 KB (779 words) - 16:44, 11 October 2022
  • Thumbnail for Myosin binding protein C, cardiac
    protein and are not thoroughly characterised yet, such as acetylation, citrullination, S-glutathiolation, S-nitrosylation and carbonylation. The cloning of...
    68 KB (8,462 words) - 19:31, 20 January 2024
  • It renders modifications of protein termini, such as acetylation and citrullination, easily accessible and searchable and provides the means to identify...
    11 KB (1,016 words) - 09:33, 29 March 2024
  • Genomic and Precision Medicine Distinguished Achievement Award Role of citrullination in diagnosing diseases (2021) US 11,105,817 B2 Biomarkers of myocardial...
    12 KB (1,094 words) - 00:39, 24 August 2024