Clozapine N-oxide (CNO) is a synthetic drug used mainly in biomedical research as a ligand to activate Designer Receptors Exclusively Activated by Designer...

(GPCR) engineered to respond exclusively to synthetic ligands, like clozapine N-oxide (CNO), and not to endogenous ligands. Several types of these receptors...

Clozapine, sold under the brand name Clozaril among others, is a psychiatric medication and was the first atypical antipsychotic (also called second-generation...

company CNO (gene), which encodes the protein cappuccino homolog Clozapine N-oxide, a synthetic ligand which activates a receptor Fulminate, a chemical...

factitious air, among others, is a chemical compound, an oxide of nitrogen with the formula N 2O. At room temperature, it is a colourless non-flammable...

to respond exclusively to synthetic small molecules ligands, like clozapine N-oxide (CNO), and not to their natural ligand(s). RASSL's represent a GPCR-based...

-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine) and its salts Clozapine N-oxide (8-chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine)...

temporal precision due to the pharmacokinetics of the ligand, such as clozapine-N-oxide (CNO) or deschloroclozapine (DCZ). It is important to note that simultaneous...

coupled receptors that could be activated by the inert small molecule clozapine N-oxide but insensitive to the native ligand, acetylcholine; these receptors...

round around the new surroundings. The chemogenetic activating drug clozapine N-oxide (CNO), but not vehicle, reversibly impairs episodic memory replay...

Noracymethadol Norlevorphanol Normethadone Normorphine Norpipanone Codeine-N-oxide Morphine-N-oxide Opium Oripavine Oxycodone Oxymorphone Pethidine Piminodine Piritramide...

epilepsy on its own had no effect, but when activated by the drug clozapine N-oxide it suppressed seizures. The treatment had no detectable side effects...

DMT started to be sold on the black market in 2018. Dimethyltryptamine-N-oxide Psychedelic drug List of psychoactive plants MPMI Serotonergic psychedelic...

Flavin-containing monooxygenase 3 (FMO3), also known as dimethylaniline monooxygenase [N-oxide-forming] 3 and trimethylamine monooxygenase, is a flavoprotein enzyme (EC...

member of the dibenzoxazepine class and structurally very similar to clozapine. Several researchers have argued that loxapine, initially classified as...

DHA-clozapine (tentative trade name Clozaprexin) is an atypical antipsychotic drug candidate that was created and originally tested by chemists at Protarga...

risperidone and olanzapine; and produce weight gain similar to risperidone, clozapine and aripiprazole. They concluded that it produces suicide attempt, suicide;...

methylation and/or glucuronide/sulfate conjugation; and (2) N-dealkylation, deamination, and oxidation to the corresponding benzoic acid derivatives conjugated...

possible (although this may temporarily worsen symptoms) or switching to clozapine. Other medications such as valbenazine, tetrabenazine, or botulinum toxin...

damage to the penis. Sildenafil should not be taken by people on nitric oxide donors such as nitroglycerin (glycerin trinitrate), as this may result in...

antipsychotics, in which case clozapine is offered. In a network comparative meta-analysis of 15 antipsychotic drugs, clozapine was significantly more effective...

human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist". The Journal of Pharmacology...

5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine), also known as O-methylbufotenin or mebufotenin (INNTooltip International Nonproprietary Name), is a psychedelic...

physical forms for clozapine as compared to 60 distinct physical forms for olanzapine. The experimental screening results of clozapine are consistent with...

"High-performance liquid chromatographic method for a clozapine analogue, CGS 13429, and its N-oxide and desmethyl metabolites". Journal of Chromatography...

150–200 mg/day of DHA+EPA for children 4–6 years old.[medical citation needed] DHA-clozapine List of omega−3 fatty acids Polyunsaturated fatty acids "Omega-3 fatty...

(September 2006). "Glycine transporter I inhibitor, N-methylglycine (sarcosine), added to clozapine for the treatment of schizophrenia". Biological Psychiatry...

N-Methyltryptamine (NMT) (or mono-methyltryptamine) is a member of the substituted tryptamine chemical class and a natural product which is biosynthesized...

treatment option (although this is based on low-quality evidence) in clozapine-resistant cases of schizophrenia. Another recent study concluded that...

N-Ethyltryptamine (NET) is a tryptamine that is structurally related to N-methyltryptamine (NMT) and the psychedelic drugs N,N-dimethyltryptamine (DMT)...