molecular biology, the cohesin domain is a protein domain. It interacts with a complementary domain, termed the dockerin domain. The cohesin-dockerin interaction...

Cohesin is a protein complex that mediates sister chromatid cohesion, homologous recombination, and DNA looping. Cohesin is formed of SMC3, SMC1, SCC1...

aid of CTCF and cohesin proteins. Furthermore, it has been proposed that the stiffness of TAD boundaries itself could cause the domain insulation and TAD...

complex with Cohesin. There are three types of Dockerin domains: I, II and III which bind to Cohesin Type I, Cohesin Type II and Cohesin Type III respectively...

subunits into the cohesive complex, by combining its cohesin domains with a typical dockerin domain present on each of the subunit enzymes. The scaffoldin...

DNA or chromatin. In this process, SMC complexes, such as condensin or cohesin, bind to DNA/chromatin, use ATP-driven motor activity to reel in DNA, and...

is a subunit of the Cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. Cohesin is formed of SMC3, SMC1...

subunit of the cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. In somatic cells, cohesin is formed of...

generate Topologically associating domains (TADs). As well as mediating cohesion and regulating DNA architecture the cohesin complex is required for DNA repair...

self-interacting domain boundaries, and can anchor the chromatin to the nuclear lamina. CTCF is also involved in V(D)J recombination. Cohesin: The cohesin complex...

Chromosomal regulation Cohesin subunit SA2/Scc3 Cohesin regulator Wapl Cohesin regulator Pds5 Cohesin loading factor Scc2 Cohesin protease Separase Condensin...

Scc proteins. Cohesin may originally interact with chromosomes via the ATPase domains of the SMC proteins. In yeast, the loading of cohesin on the chromosomes...

chromosome cohesion during cell division. It does this by preventing the cohesin complex, which regulates chromatid separation, from prematurely dissociating...

the cohesin complex suggests that this complex connects directly both sister chromatids. In this proposed structure, the SMC components of cohesin play...

NIPBL.  The C-terminal domain of RAD21 forms a winged helix that binds two β-sheets in the Smc1 head domain. WAPL releases cohesin from DNA by opening the...

functions: A pair of SMC1 and SMC3 constitutes the core subunits of the cohesin complexes involved in sister chromatid cohesion. SMC1 and SMC3 also have...

key regulator of the Cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. Cohesin is formed of SMC3, SMC1...

a cysteine protease responsible for triggering anaphase by hydrolysing cohesin, which is the protein responsible for binding sister chromatids during...

two DNA loci bound by the transcription factor CTCF and co-occupied by cohesin. Insulated neighborhoods are thought to be structural and functional units...

histone methyltransferase and the Rad9 checkpoint adaptor contribute to cohesin-dependent double-strand break repair by sister chromatid recombination...

M, Mira-Bontenbal H, et al. (December 2013). "Cohesin-mediated interactions organize chromosomal domain architecture". The EMBO Journal. 32 (24): 3119–3129...

in chromatin form) are linked along their length by the action of the cohesin complex. It is now believed that this complex is mostly released from chromosome...

down the center. Unlike in mitosis, only the cohesin from the chromosome arms is degraded while the cohesin surrounding the centromere remains protected...

Clostridium thermocellum, the dockerin domains of the catalytic polypeptides can bind equally well to any cohesin from the same organism. More recently...

targets securin for destruction, enabling the eventual destruction of cohesin and thus sister chromatid separation. It also targets S and M-phase (S/M)...

forming and disappearing. The loops are regulated by two main elements: Cohesins, protein complexes that generate loops by extrusion of the DNA fiber through...

cleavage of cohesin, the protein complex that binds sister chromatids together. During metaphase, sister chromatids are linked by intact cohesin complexes...

meiosis. Budding yeast Cdc5 is required in meiosis I for the removal of cohesins from chromosome arms, for the co-orientation of homologous chromosomes...

2010). "Drosophila ORC localizes to open chromatin and marks sites of cohesin complex loading". Genome Research. 20 (2): 201–11. doi:10.1101/gr.097873...

November 2017). "Two independent modes of chromatin organization revealed by cohesin removal". Nature. 551 (7678): 51–56. Bibcode:2017Natur.551...51S. doi:10...