Cyclooxygenase-2 inhibitors (COX-2 inhibitors), also known as coxibs, are a type of nonsteroidal anti-inflammatory drug (NSAID) that directly target cyclooxygenase-2...

using selective COX-2 inhibitors. Arachidonic acid Cyclooxygenase Cyclooxygenase 1 Cyclooxygenase 2 NSAID COX-2 selective inhibitor Marnett, L. J.; Kalgutkar...

Cyclooxygenase-2 (COX-2), also known as Prostaglandin-endoperoxide synthase 2 (HUGO PTGS2), is an enzyme that in humans is encoded by the PTGS2 gene....

carcinoma Cyclooxygenase-1 Cyclooxygenase-2 Cyclooxygenase-3 (not functional in humans) Discovery and development of COX-2 selective inhibitors PDB: 1CQE​;...

their introduction in 1948. NSAIDs work by inhibiting the activity of cyclooxygenase enzymes (the COX-1 and COX-2 isoenzymes). In cells, these enzymes are...

and most recently discovered cyclooxygenase (COX3050) isozyme, while the first two to be discovered were COX-1 and COX-2. The COX-3 isozyme is encoded...

anti-inflammatory drug (NSAID), acting specifically as a relatively selective cyclooxygenase-2 inhibitor. However, the pharmacological profile of nimesulide is peculiar...

the "Use of the nonselective NSAID diclofenac and the selective cyclooxygenase-2 inhibitor rofecoxib was associated with an increased risk of cardiovascular...

lowering blood pressure. As a result of inhibiting the ACE enzyme in the bradykinin system, the ACE inhibitor drugs allow for increased levels of bradykinin...

Arachidonic acid Cyclooxygenase Cyclooxygenase 2 NSAID Discovery and development of COX-2 selective inhibitors COX-2 selective inhibitor GRCh38: Ensembl...

Celecoxib, sold under the brand name Celebrex among others, is a COX-2 inhibitor and nonsteroidal anti-inflammatory drug (NSAID). It is used to treat...

painful menstruation and menstrual symptoms. It is a selective cyclooxygenase-2 inhibitor. It was patented in 1995. Valdecoxib was manufactured and marketed...

Kleindienst N, Möller HJ, Arolt V, Riedel M (July 2006). "The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results...

A, Cerovecki A, Goldstein-Müller B, et al. (July 2006). "The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results...

2008). "Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man". FASEB Journal. 22 (2): 383–90. doi:10.1096/fj.07-8506com. PMID 17884974...

MF, Silberstein SD (2002). "Hemicrania continua responds to cyclooxygenase-2 inhibitors". Headache. 42 (6): 530–1. doi:10.1046/j.1526-4610.2002.02131...

reversed once the glucocorticoids therapy is stopped. As NSAIDs inhibit cyclooxygenase, the production of thromboxane, a natural coagulator, is inhibited...

NF-κB [58]. Another important activity for hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase [59]. Moreover, this species attenuated...

FitzGerald GA, Skarke C (October 2013). "GCG100649, A Novel Cyclooxygenase-2 Inhibitor, Exhibits a Drug Disposition Profile in Healthy Volunteers Compatible...

A. (2002). Evaluation of Preoperative Administration of the Cyclooxygenase-2 Inhibitor Rofecoxib for the Treatment of Postoperative Pain after Lumbar...

inhibiting the production of prostaglandins, endogenous signaling molecules known to cause these symptoms. It does this by inhibiting cyclooxygenase,...

molecular cloning, signal ... Ito Y (2003). "Effects of selective cyclooxygenase inhibitors on ischemia/reperfusion-induced hepatic microcirculatory dysfunction...

PMID 12237248. White, WB (2007). "Cardiovascular effects of the cyclooxygenase inhibitors". Hypertension. 49 (3): 408–418. doi:10.1161/01.HYP.0000258106...

inhibition the substrate and inhibitor cannot bind to the enzyme at the same time.: 134  This usually results from the inhibitor having an affinity for the...

inhibits types 1 and 2 (IC50Tooltip half-maximal inhibitory concentration = 8.5 nM), but also 3β-HSDTooltip 3β-hydroxysteroid dehydrogenase inhibitor...

of cyclooxygenases, COX-1 and COX-2, are acted on by aspirin. Aspirin irreversibly inhibits COX-1 and modifies the enzymatic activity of COX-2. COX-2 normally...

synthesis by competitive blocking of the enzyme cyclooxygenase (COX). Ketorolac is a non-selective COX inhibitor. It is considered a first-generation NSAID...

topical formulations of rofecoxib. COX-2 selective inhibitor Discovery and development of cyclooxygenase 2 inhibitors David Graham (epidemiologist) "Vioxx...

NF-κB [58]. Another important activity for hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase [59]. Moreover, this species attenuated...

inhibitor binds to the active site where it is modified by the enzyme to produce a reactive group that reacts irreversibly to form a stable inhibitor-enzyme...