ETV6 (i.e. translocation-Ets-leukemia virus) protein is a transcription factor that in humans is encoded by the ETV6 (previously known as TEL) gene. The...
38 KB (4,620 words) - 01:56, 3 December 2023
PDGFRB (section PDGFRB-ETV6 translocations)
mutations is the translocation of PDGFRB gene with the ETV6 gene (also termed ETS variant gene 6). The ETV6 gene codes for a transcription factor protein that...
31 KB (3,403 words) - 18:14, 24 December 2023
ETV6-NTRK3 gene fusion is the translocation of genetic material between the ETV6 gene located on the short arm (designated p) of chromosome 12 at position...
9 KB (1,117 words) - 22:00, 29 March 2024
translocations between ETV6 and ACSL6 at different chromosome break points create various t(5:12)(q31;p13) ETV6-ACSL6 fusion genes encoding ETV6-ACSL6 fusion proteins...
48 KB (5,760 words) - 10:46, 16 November 2024
Technology-Enhanced Learning Tetraethyllead, a gasoline additive to make leaded gasoline ETV6, previously known as TEL, a gene Transporter erector launcher, a mobile missile...
1 KB (189 words) - 17:27, 25 March 2024
fusion gene, ETV6-NTRK3, plus individual cases exhibiting trisomy for chromosomes 8, 11, 17, or 20. The histology, association with the ETV6-NRTK3 fusion...
9 KB (896 words) - 16:48, 22 July 2024
of cases are associated with a known genetic syndrome. Rare mutations in ETV6 and PAX5 are associated with a familial form of ALL with autosomal dominant...
78 KB (7,830 words) - 05:56, 10 November 2024
ETV6 gene located in band one, three sub-band 2 on chromosome 12. The fusion gene product, ETV6-NTRK3, encodes a chimeric mutant protein, termed ETV6-NTRK3...
26 KB (3,130 words) - 14:59, 15 October 2024
neoplasms with germline ANKRD26 mutation Myeloid neoplasms with germline ETV6 mutation Myeloid neoplasms with germline GATA2 mutation Acute myeloid leukaemia...
24 KB (2,329 words) - 20:43, 2 October 2024
thrombocytopenia Epstein syndrome (associated with giant platelet disorder) ETV6 related thrombocytopenia Fanconi anemia Filaminopathies A FYB related thrombocytopenia...
32 KB (2,879 words) - 14:41, 24 August 2024
an acquired mutation, the ETV6-NTRK3 fusion gene. This gene results from a translocation of genetic material from the ETV6 gene located on the short arm...
18 KB (2,254 words) - 07:41, 29 September 2024
The ETV6-NTRK3 fusion gene's product, ETV6-NTRK3 protein, contains the N-terminus of ETV6 that is responsible for its dimerization/polymerization ETV6, a...
16 KB (1,955 words) - 01:29, 20 August 2023
mutations in JAK2, ABL1, and FLT2 and chromosomal translocations that create the ETV6-ACSL6 fusion gene. Chronic eosinophilic leukemia, not otherwise specified...
50 KB (5,523 words) - 06:20, 11 November 2024
is expressed is called a fusion protein. Chimeric gene De novo gene birth ETV6-NTRK3 gene fusion Exon shuffling Gene duplication Horizontal gene transfer...
17 KB (1,928 words) - 19:40, 5 August 2024
HGNC:33834 Q6ZN32 5141 ETV4 HGNC:3493 P43268 5142 ETV5 HGNC:3494 P41161 5143 ETV6 HGNC:3495 P41212 5144 ETV7 HGNC:18160 Q9Y603 5145 EVA1A HGNC:25816 Q9H8M9...
277 KB (17 words) - 18:41, 6 October 2024
This genetic abnormality is a balanced genetic translocation that forms a ETV6-NTRK3 fusion gene which appears involved in promoting the development and/or...
12 KB (1,526 words) - 08:11, 2 February 2024
end of JAK2. The oligomerisation domain of the TEL protein (also called ETV6) becomes juxtaposed to the tyrosine kinase domain of JAK2, and as result...
2 KB (205 words) - 21:56, 15 August 2023
ENSG00000244405 Ets Known motif – High-throughput in vitro [219] DVCGGAWRY ETV6 ENSG00000139083 Ets Known motif – High-throughput in vitro [220] SCGGAASCGGAAGYR...
374 KB (81 words) - 02:10, 23 September 2023
chromosomal translocations such as t(9;22) BCR-ABL, t(15;17) PML-RARA and t(12;21) ETV6-RUNX1 (TEL-AML1). Patient-specific MRD detection using immunoglobulin (IG)...
29 KB (3,533 words) - 00:48, 30 May 2024
which complete genome data are available. JAK2 gene fusions with the TEL(ETV6) (TEL-JAK2) and PCM1 genes have been found in patients suffering leukemia...
28 KB (3,166 words) - 19:57, 8 August 2024
for Grb2 contributes to transformation and leukemogenesis by the Tel-Abl (ETV6-Abl) tyrosine kinase". Molecular and Cellular Biology. 24 (11): 4685–4695...
14 KB (1,541 words) - 16:10, 15 March 2024
den Berghe H, Marynen P (1997). "Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid...
10 KB (1,061 words) - 09:46, 9 October 2024
transcriptional repressor and interacts physically and functionally with TEL (ETV6)". J. Biol. Chem. 278 (17): 15412–20. doi:10.1074/jbc.M300592200. PMID 12588862...
5 KB (710 words) - 16:34, 3 April 2024
factor 1 receptor, DCTN1, DNM1, Dock180, Dystroglycan, EPH receptor A2, ETV6, Epidermal growth factor receptor, Erythropoietin receptor, FRS2, Fas ligand...
82 KB (9,365 words) - 15:39, 31 March 2024
that is expressed in hematopoietic tissues and can associate with TEL1/ETV6". Blood. 95 (11): 3341–8. doi:10.1182/blood.V95.11.3341. PMID 10828014. Gu...
4 KB (499 words) - 22:51, 3 March 2023
LY, Nikiforova MN, Yue NJ, Zhang M, Mabuchi K, Tronko MD, Nikiforov YE. ETV6-NTRK3 is a common chromosomal rearrangement in radiation-associated thyroid...
19 KB (2,537 words) - 21:12, 8 November 2024
(2002). "Chronic myelocytic leukemia with eosinophilia, t(9;12)(q34;p13), and ETV6-ABL gene rearrangement: case report and review of the literature". Cancer...
30 KB (3,502 words) - 08:07, 14 August 2024
Douet-Guilbert N, Morel F, Le Bris MJ, Basinko A, De Braekeleer M (August 2012). "ETV6 fusion genes in hematological malignancies: a review". Leukemia Research...
29 KB (3,354 words) - 17:01, 9 December 2023
Late B Lymphopoiesis". Retrieved 2019-01-08. "Molecular role of the PAX5‐ETV6 oncoprotein in promoting B‐cell acute lymphoblastic leukemia". Retrieved...
11 KB (1,031 words) - 01:10, 26 October 2024
Morrison KB, Tognon CE, Garnett MJ, Deal C, Sorensen PH (August 2002). "ETV6-NTRK3 transformation requires insulin-like growth factor 1 receptor signaling...
34 KB (4,304 words) - 07:20, 3 September 2024