Endothelins are peptides with receptors and effects in many body organs. Endothelin constricts blood vessels and raises blood pressure. The endothelins...

Endothelin receptor type A, also known as ETA, is a human G protein-coupled receptor. Endothelin receptor type A has been shown to interact with HDAC7A...

An endothelin receptor antagonist (ERA) is a drug that blocks endothelin receptors. Three main kinds of ERAs exist: Dual ET Receptor Antagonists, which...

is proteolytically processed to release endothelin 1. Endothelin 1 is one of three isoforms of human endothelin. Preproendothelin is precursor of the peptide...

There are at least four known endothelin receptors, ETA, ETB1, ETB2 and ETC, all of which are G protein-coupled receptors whose activation result in elevation...

Endothelin receptor type B, (ET-B) is a protein that in humans is encoded by the EDNRB gene. Endothelin receptor type B is a G protein-coupled receptor...

taken by mouth. Aprocitentan is a dual endothelin-1 antagonist that targets both endothelin A and endothelin B receptors. Aprocitentan was approved for...

activity) decreases. Endothelin-1 is a peptide (comprising 21 amino acids) that is produced in endothelial cells. It acts on the endothelin receptors ETA and...

Macitentan, sold under the brand name Opsumit, is an endothelin receptor antagonist developed by Actelion and approved for the treatment of pulmonary arterial...

Matsuda, Yoichi; Akiyama, Toyoko (February 2012). "Gene Duplication of endothelin 3 Is Closely Correlated with the Hyperpigmentation of the Internal Organs...

Endothelin-3 is a protein that in humans is encoded by the EDN3 gene. The protein encoded by this gene is a member of the endothelin family. Endothelins...

Endothelin 2 (ET-2) is a protein encoded by the EDN2 gene in humans. It was first discovered in 1988 by Yanagisawa and team and belongs to a family of...

Endothelin-converting enzyme 1 (EC 3.4.24.71, endothelin-converting enzyme, ECE-1) is an enzyme. This enzyme catalyses the following chemical reaction...

Bosentan, sold under the brand name Tracleer among others, is a dual endothelin receptor antagonist medication used in the treatment of pulmonary artery...

decrease collagen degradation and increase extracellular matrix production. Endothelin signalling is implicated in the pathophysiology of fibrosis. Vitamin D...

hormones; angiotensin II, endothelin-1 and the catecholamines (e.g. noradrenaline).[citation needed] Angiotensin-II and endothelin-1 are hormones that bind...

Endothelin converting enzyme 1, also known as ECE1, is an enzyme which in humans is encoded by the ECE1 gene. Endothelin-converting enzyme-1 is involved...

to Hirschsprung's disease in humans. A mutation in the middle of the endothelin receptor type B (EDNRB) gene causes lethal white syndrome when homozygous...

the brand name Tyvalzi) is a synthetic analog of endothelin-1 that works as a selective endothelin-B receptor agonist. In May 2023, it was approved in...

the treatment of pulmonary hypertension. It is an endothelin receptor antagonist. The peptide endothelin constricts muscles in blood vessels, increasing...

vasoconstriction, including the release of vasoconstrictor substances such as endothelin and angiotensin II, both of which play crucial roles in the modulation...

EtBr may refer to: Bromoethane Endothelin_B_receptor (when written as ETBR) Ethidium bromide This disambiguation page lists articles associated with the...

sympathetic drive in hypertension include reactive oxygen species and endothelin. Some studies have shown that hypertensive patients manifest greater vasoconstrictor...

transmembrane zinc-dependent endopeptidase which is responsible for cleaving endothelin-3. The KEL gene encodes a type II transmembrane glycoprotein that is the...

signaling, cardiac hypertrophy signaling, Wnt signaling, Notch signaling, and endothelin 1 signaling. Of the 16 genes identified in these pathways, three were...

inhibitor) Celecoxib (COX-2 inhibitor) Parecoxib (COX-2 inhibitor) Bosentan (endothelin receptor antagonist) Dofetilide (class III antiarrhythmic) Dronedarone...

thought there is a massive degranulation of vasoconstrictors, including endothelins and free radicals, that cause the vasospasm. Intracranial aneurysms may...

Carl-Johan (2016-02-16). "A Complex Genomic Rearrangement Involving the Endothelin 3 Locus Causes Dermal Hyperpigmentation in the Chicken". PLOS Genet. 7...

with prediabetes or Type 2 diabetes mellitus. Oxytocin (OXT) Omentin Endothelin-1 Nesfatin-1 Irisin Betatrophin Hepatocyte growth factor (HGF) Fibroblast...

dephosphorylation of MLC ↑SERCA → ↓intracellular Ca2+ NO receptor on endothelium ↓endothelin synthesis epinephrine (adrenaline) β-2 adrenergic receptor ↑Gs activity...