nuclear estrogen receptors (ERα and ERβ), which are members of the nuclear receptor family of intracellular receptors, and membrane estrogen receptors (mERs)...
35 KB (3,818 words) - 10:04, 26 August 2024
Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a...
58 KB (6,133 words) - 05:31, 13 July 2024
Selective estrogen receptor modulators (SERMs), also known as estrogen receptor agonists/antagonists (ERAAs), are a class of drugs that act on estrogen receptors...
56 KB (6,363 words) - 06:33, 26 September 2024
they bind to and activate estrogen receptors (ERs) which in turn modulate the expression of many genes. Additionally, estrogens bind to and activate rapid-signaling...
73 KB (7,786 words) - 15:17, 24 September 2024
Estrogen receptor beta (ERβ) also known as NR3A2 (nuclear receptor subfamily 3, group A, member 2) is one of two main types of estrogen receptor—a nuclear...
39 KB (4,526 words) - 06:00, 25 July 2024
Antiestrogen (redirect from Estrogen receptor antagonists)
effects in the body. They act by blocking the estrogen receptor (ER) and/or inhibiting or suppressing estrogen production. Antiestrogens are one of three...
8 KB (745 words) - 06:15, 3 September 2024
nuclear receptors include members of subfamily 3, such as the androgen receptor, estrogen receptors, glucocorticoid receptor, and progesterone receptor. It...
74 KB (6,683 words) - 09:55, 12 September 2024
Estrogen-related receptor alpha (ERRα), also known as NR3B1 (nuclear receptor subfamily 3, group B, member 1), is a nuclear receptor that in humans is...
17 KB (1,995 words) - 21:24, 29 March 2024
Membrane estrogen receptors (mERs) are a group of receptors which bind estrogen. Unlike nuclear estrogen receptors, which mediate their effects via slower...
19 KB (1,985 words) - 03:22, 24 May 2024
caused by a defective estrogen receptor (ER) – specifically, the estrogen receptor alpha (ERα) – that results in an inability of estrogen to mediate its biological...
35 KB (3,802 words) - 22:12, 6 September 2024
A selective estrogen receptor degrader or downregulator (SERD) is a type of drug that selectively binds to the estrogen receptor (ER) and induces its degradation...
6 KB (530 words) - 16:44, 28 August 2024
with estrogen receptors, but do not appear to bind estrogens or other tested steroid hormones. There are three human estrogen related receptors: ERRα...
11 KB (1,175 words) - 13:05, 3 December 2023
studied steroid hormone receptors are members of the nuclear receptor subfamily 3 (NR3) that include receptors for estrogen (group NR3A) and 3-ketosteroids...
23 KB (2,796 words) - 19:08, 19 February 2024
GPER (redirect from G Protein-coupled Estrogen Receptor 1)
G protein-coupled estrogen receptor 1 (GPER), also known as G protein-coupled receptor 30 (GPR30), is a protein that in humans is encoded by the GPER gene...
35 KB (3,987 words) - 16:29, 25 July 2024
Tamoxifen (category Selective estrogen receptor modulators)
sold under the brand name Nolvadex among others, is a selective estrogen receptor modulator used to prevent breast cancer in women and men. It is also...
88 KB (8,913 words) - 02:42, 18 September 2024
of selective estrogen receptor modulators (SERMs) became evident. The first SERM, tamoxifen, was originally developed as an anti-estrogen contraceptive...
74 KB (6,763 words) - 03:02, 16 September 2024
Clomifene (category Selective estrogen receptor modulators)
unknown cause or who are pregnant. Clomifene is in the selective estrogen receptor modulator (SERM) family of medication and is a nonsteroidal medication...
46 KB (4,780 words) - 12:20, 12 September 2024
The estrogen receptor test (ERT) is a laboratory test to determine whether cancer cells have estrogen receptors. This information can guide treatment...
10 KB (1,332 words) - 19:38, 30 June 2024
Hormonal therapy (oncology) (redirect from Estrogen therapy (oncology))
intracellular, as in the case of steroid hormone receptors.[citation needed] Selective estrogen receptor modulators (SERMs) are an important class of hormonal...
12 KB (1,363 words) - 20:23, 16 August 2024
Endocrine therapy is a common treatment for estrogen receptor positive breast cancer. However, resistance to this therapy can develop, leading to relapse...
27 KB (3,317 words) - 11:14, 7 January 2024
Raloxifene (category Selective estrogen receptor modulators)
a selective estrogen receptor modulator (SERM) and therefore a mixed agonist–antagonist of the estrogen receptor (ER). It has estrogenic effects in bone...
47 KB (4,786 words) - 04:09, 27 September 2024
among others. Estrogens are agonists of the estrogen receptors, the biological targets of endogenous estrogens like estradiol. They have important effects...
131 KB (14,549 words) - 22:25, 15 September 2024
Hormone therapy (redirect from Anti-estrogen therapy)
cancer Estrogen deprivation therapy for women with estrogen receptor-positive breast cancer High-dose estrogen therapy for women with estrogen receptor-positive...
7 KB (751 words) - 09:25, 18 August 2024
cancers require estrogen to grow. Those cancers have estrogen receptors (ERs), and are called ER-positive. They may also be called estrogen-responsive,...
19 KB (1,832 words) - 12:55, 3 August 2024
selective estrogen receptor modulator and selective estrogen receptor degrader for breast cancer [30] Fulvestrant-3 boronic acid (ZB716) – estrogen receptor antagonist...
14 KB (1,217 words) - 08:59, 1 August 2024
Estradiol (category Estrogens)
loss of bone mass due to a relative estrogen deficiency. The estrogen receptor, as well as the progesterone receptor, have been detected in the skin, including...
75 KB (7,245 words) - 18:06, 26 August 2024
Tibolone (category Synthetic estrogens)
with weak estrogenic, progestogenic, and androgenic activity, and hence is an agonist of the estrogen, progesterone, and androgen receptors. It is a prodrug...
56 KB (5,314 words) - 00:45, 21 March 2024
are estrogens, or agonists of the estrogen receptor, the biological target of estrogens like estradiol. Compared to estradiol, certain estrogens in CEEs...
58 KB (6,452 words) - 20:50, 17 September 2024
Genistein (category Glycine receptor antagonists)
interact with animal and human estrogen receptors, causing effects in the body similar to those caused by the hormone estrogen. Isoflavones also produce non-hormonal...
45 KB (4,451 words) - 16:57, 22 September 2024
refers to estrogen receptor positive tumors (i.e. tumors that contain estrogen receptor positive cells), but can also include progesterone receptor positive...
5 KB (508 words) - 10:02, 27 December 2023