• Thumbnail for FOXA1
    protein A1 (FOXA1), also known as hepatocyte nuclear factor 3-alpha (HNF-3A), is a protein that in humans is encoded by the FOXA1 gene. FOXA1 is a pioneer...
    9 KB (1,062 words) - 03:06, 12 November 2024
  • factors. In hepatic cell differentiation the activating pioneer factor FOXA1 recruits a repressor, grg3, that prevents transcription until the repressor...
    24 KB (2,798 words) - 12:07, 7 September 2024
  • Thumbnail for Prostate cancer
    that disable SPOP (up to 15% of tumors), and mutations that hyperactivate FOXA1 (up to 5% of tumors). Metastatic prostate cancer tends to have more genetic...
    77 KB (8,906 words) - 21:26, 12 December 2024
  • Meyer CA, Wang Q, Zhang Y, Li W, Carroll JS, Liu XS, Brown M (March 2008). "FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription"...
    2 KB (265 words) - 01:35, 24 March 2024
  • FOX proteins into subclasses (FOXA-FOXS) based on sequence conservation. FOXA1, FOXA2, FOXA3 (See also Hepatocyte nuclear factors.) FOXB1, FOXB2 FOXC1...
    8 KB (874 words) - 23:04, 18 August 2023
  • ENSG00000075426 bZIP Known motif – High-throughput in vitro [238] TKANTCAYNRTGACGTCAY FOXA1 ENSG00000129514 Forkhead Known motif – High-throughput in vitro [239] BVYTAWGTAAACAAW...
    374 KB (81 words) - 02:10, 23 September 2023
  • Thumbnail for BPIFA4P
    while the transcription factor FOXA1 activates the expression of BASE/BPIFA4P. The undetermined interplay between ERα and FOXA1 is likely to be important in...
    13 KB (1,560 words) - 04:41, 21 July 2024
  • when ErbB2 remains on. Carroll also discovered the role of pioneer factor FOXA1 in breast cancer, demonstrating that it is key in enabling the estrogen...
    10 KB (854 words) - 10:19, 7 April 2024
  • Thumbnail for FOXA2
    of the Forkhead box (FOX) transcription factors, the other members being FOXA1 and FOXA3. This subfamily of mammalian FOX proteins was first identified...
    12 KB (1,552 words) - 13:12, 4 December 2024
  • Thumbnail for Anduril (workflow engine)
    S.; Kallioniemi, O.; Hautaniemi, S.; Jänne, O. A. (2011). "Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate...
    13 KB (1,169 words) - 18:44, 1 December 2023
  • Lobular Carcinoma 203 Lobular carcinoma distinct from ductal carcinoma; FOXA1 elevated in lobular carcinoma, GATA3 elevated in ductal carcinoma; lobular...
    82 KB (7,468 words) - 19:06, 19 April 2024
  • Thumbnail for CELSR1
    receptor binding reveals long-range regulation requiring the forkhead protein FoxA1". Cell. 122 (1): 33–43. doi:10.1016/j.cell.2005.05.008. PMID 16009131. S2CID 16841542...
    6 KB (731 words) - 06:13, 2 May 2024
  • → heptaocyte-like cells (Gata4, Hnf1alpha, and Foxa3) or (Hnf4alpha and Foxa1, Foxa2 or Foxa3) Fibroblasts → neurons (Ascl1, Pou3f2/Brn2, and Myt1l) Human...
    14 KB (1,158 words) - 01:42, 22 December 2024
  • HGNC:3797 P53539 5778 FOSL1 HGNC:13718 P15407 5779 FOSL2 HGNC:3798 P15408 5780 FOXA1 HGNC:5021 P55317 5781 FOXA2 HGNC:5022 Q9Y261 5782 FOXA3 HGNC:5023 P55318...
    277 KB (17 words) - 18:41, 6 October 2024
  • Thumbnail for Insulated neighborhood
    (11 September 2014). "Identification of a regulatory variant that binds FOXA1 and FOXA2 at the CDC123/CAMK1D type 2 diabetes GWAS locus". PLOS Genetics...
    24 KB (2,487 words) - 06:31, 11 May 2024
  • Thumbnail for P19 cell
    H; Huang, X; Yu, L; Meng, X; Chen, Y (Sep 2010). "Increased levels of FoxA1 transcription factor in pluripotent P19 embryonal carcinoma cells stimulate...
    18 KB (2,304 words) - 18:27, 22 July 2024
  • Neuronal Cells from Alzheimer's Disease Patients Reveals an Association with FOXA1 and FOXA2 Gene Regulatory Networks., 2016; (contrib.) Induced pluripotent...
    9 KB (832 words) - 12:13, 26 September 2024
  • Thumbnail for GATA3
    the following transcription factor regulators: ZFPM1 and ZFPM2; LMO1; and FOXA1. These regulators may promote or inhibit GATA3 in stimulating the expression...
    31 KB (3,723 words) - 06:25, 25 July 2024
  • Thumbnail for SPOP
    MA, Garraway LA (Jun 2012). "Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer". Nature Genetics. 44 (6): 685–9...
    10 KB (1,289 words) - 03:43, 25 November 2024
  • 90589.2008. PMC 2711760. PMID 19407216. Ye, D. Z.; Kaestner, K. H. (2009). "Foxa1 and Foxa2 Control the Differentiation of Goblet and Enteroendocrine L- and...
    43 KB (3,330 words) - 04:15, 25 July 2024
  • Thumbnail for MED12
    MA, Garraway LA (Jun 2012). "Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer" (PDF). Nature Genetics. 44 (6):...
    14 KB (1,784 words) - 02:14, 19 June 2024
  • contain a winged helix DNA-binding domain and bind to DNA as monomers. HNF3α/FOXA1 (forkhead box A1) HNF3β/FOXA2 (forkhead box A2) HNF3γ/FOXA3 (forkhead box...
    8 KB (585 words) - 20:31, 30 May 2024
  • Thumbnail for SNAP29
    receptor binding reveals long-range regulation requiring the forkhead protein FoxA1". Cell. 122 (1): 33–43. doi:10.1016/j.cell.2005.05.008. PMID 16009131. S2CID 16841542...
    9 KB (1,108 words) - 06:28, 18 December 2023
  • receptor binding reveals long-range regulation requiring the forehead protein FoxA1". Cell. 122 (1): 33–43. doi:10.1016/j.cell.2005.05.008. PMID 16009131. S2CID 16841542...
    22 KB (2,397 words) - 19:08, 18 October 2024
  • Thumbnail for THOC5
    receptor binding reveals long-range regulation requiring the forkhead protein FoxA1". Cell. 122 (1): 33–43. doi:10.1016/j.cell.2005.05.008. PMID 16009131. Olsen...
    11 KB (1,483 words) - 11:43, 15 November 2024
  • Thumbnail for ISLR
    factor of activated T-cells Hepatocyte nuclear factor 3 (alpha, beta) (FOXA1, FOXA2) E2F transcription factor 1 Eomesodermin, TBR-2 (T-box, brain, 2)...
    46 KB (3,998 words) - 06:32, 20 September 2024
  • Thumbnail for Transcription factor Sp1
    Yang 1 (YY1)] and negative regulators [GATA2, forkhead box protein A1 (FoxA1), and CCAAT enhancer-binding protein b (C/EBPb)] of FTMT transcription have...
    30 KB (3,440 words) - 17:01, 19 November 2024
  • Thumbnail for NK2 homeobox 1
    deregulation of transcription factors FOXA1/2 (by relaxing histone deacetylation and methylation-mediated repression of Foxa1/2 by Nkx2-1) causing reactivation...
    19 KB (2,118 words) - 19:06, 28 August 2023
  • M, Eeckhoute J, Meyer CA, Wang Q, Zhang Y, Li W, et al. (March 2008). "FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription"...
    6 KB (634 words) - 19:36, 26 November 2024
  • Thumbnail for ZNF337
    cancer cell line) Promoter TBP HeLa-S3 (cervical cancer cell line) Promoter FOXA1 HepG2 (human liver cancer cell line) Promoter SIN3A HepG2 (human liver cancer...
    30 KB (2,715 words) - 13:47, 15 August 2024