protein A1 (FOXA1), also known as hepatocyte nuclear factor 3-alpha (HNF-3A), is a protein that in humans is encoded by the FOXA1 gene. FOXA1 is a pioneer...
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factors. In hepatic cell differentiation the activating pioneer factor FOXA1 recruits a repressor, grg3, that prevents transcription until the repressor...
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that disable SPOP (up to 15% of tumors), and mutations that hyperactivate FOXA1 (up to 5% of tumors). Metastatic prostate cancer tends to have more genetic...
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Meyer CA, Wang Q, Zhang Y, Li W, Carroll JS, Liu XS, Brown M (March 2008). "FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription"...
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FOX proteins into subclasses (FOXA-FOXS) based on sequence conservation. FOXA1, FOXA2, FOXA3 (See also Hepatocyte nuclear factors.) FOXB1, FOXB2 FOXC1...
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ENSG00000075426 bZIP Known motif – High-throughput in vitro [238] TKANTCAYNRTGACGTCAY FOXA1 ENSG00000129514 Forkhead Known motif – High-throughput in vitro [239] BVYTAWGTAAACAAW...
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while the transcription factor FOXA1 activates the expression of BASE/BPIFA4P. The undetermined interplay between ERα and FOXA1 is likely to be important in...
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when ErbB2 remains on. Carroll also discovered the role of pioneer factor FOXA1 in breast cancer, demonstrating that it is key in enabling the estrogen...
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of the Forkhead box (FOX) transcription factors, the other members being FOXA1 and FOXA3. This subfamily of mammalian FOX proteins was first identified...
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S.; Kallioniemi, O.; Hautaniemi, S.; Jänne, O. A. (2011). "Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate...
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Lobular Carcinoma 203 Lobular carcinoma distinct from ductal carcinoma; FOXA1 elevated in lobular carcinoma, GATA3 elevated in ductal carcinoma; lobular...
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receptor binding reveals long-range regulation requiring the forkhead protein FoxA1". Cell. 122 (1): 33–43. doi:10.1016/j.cell.2005.05.008. PMID 16009131. S2CID 16841542...
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→ heptaocyte-like cells (Gata4, Hnf1alpha, and Foxa3) or (Hnf4alpha and Foxa1, Foxa2 or Foxa3) Fibroblasts → neurons (Ascl1, Pou3f2/Brn2, and Myt1l) Human...
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HGNC:3797 P53539 5778 FOSL1 HGNC:13718 P15407 5779 FOSL2 HGNC:3798 P15408 5780 FOXA1 HGNC:5021 P55317 5781 FOXA2 HGNC:5022 Q9Y261 5782 FOXA3 HGNC:5023 P55318...
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(11 September 2014). "Identification of a regulatory variant that binds FOXA1 and FOXA2 at the CDC123/CAMK1D type 2 diabetes GWAS locus". PLOS Genetics...
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H; Huang, X; Yu, L; Meng, X; Chen, Y (Sep 2010). "Increased levels of FoxA1 transcription factor in pluripotent P19 embryonal carcinoma cells stimulate...
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Neuronal Cells from Alzheimer's Disease Patients Reveals an Association with FOXA1 and FOXA2 Gene Regulatory Networks., 2016; (contrib.) Induced pluripotent...
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the following transcription factor regulators: ZFPM1 and ZFPM2; LMO1; and FOXA1. These regulators may promote or inhibit GATA3 in stimulating the expression...
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MA, Garraway LA (Jun 2012). "Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer". Nature Genetics. 44 (6): 685–9...
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90589.2008. PMC 2711760. PMID 19407216. Ye, D. Z.; Kaestner, K. H. (2009). "Foxa1 and Foxa2 Control the Differentiation of Goblet and Enteroendocrine L- and...
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MA, Garraway LA (Jun 2012). "Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer" (PDF). Nature Genetics. 44 (6):...
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contain a winged helix DNA-binding domain and bind to DNA as monomers. HNF3α/FOXA1 (forkhead box A1) HNF3β/FOXA2 (forkhead box A2) HNF3γ/FOXA3 (forkhead box...
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receptor binding reveals long-range regulation requiring the forkhead protein FoxA1". Cell. 122 (1): 33–43. doi:10.1016/j.cell.2005.05.008. PMID 16009131. S2CID 16841542...
9 KB (1,108 words) - 06:28, 18 December 2023
receptor binding reveals long-range regulation requiring the forehead protein FoxA1". Cell. 122 (1): 33–43. doi:10.1016/j.cell.2005.05.008. PMID 16009131. S2CID 16841542...
22 KB (2,397 words) - 19:08, 18 October 2024
receptor binding reveals long-range regulation requiring the forkhead protein FoxA1". Cell. 122 (1): 33–43. doi:10.1016/j.cell.2005.05.008. PMID 16009131. Olsen...
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factor of activated T-cells Hepatocyte nuclear factor 3 (alpha, beta) (FOXA1, FOXA2) E2F transcription factor 1 Eomesodermin, TBR-2 (T-box, brain, 2)...
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Yang 1 (YY1)] and negative regulators [GATA2, forkhead box protein A1 (FoxA1), and CCAAT enhancer-binding protein b (C/EBPb)] of FTMT transcription have...
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deregulation of transcription factors FOXA1/2 (by relaxing histone deacetylation and methylation-mediated repression of Foxa1/2 by Nkx2-1) causing reactivation...
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M, Eeckhoute J, Meyer CA, Wang Q, Zhang Y, Li W, et al. (March 2008). "FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription"...
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cancer cell line) Promoter TBP HeLa-S3 (cervical cancer cell line) Promoter FOXA1 HepG2 (human liver cancer cell line) Promoter SIN3A HepG2 (human liver cancer...
30 KB (2,715 words) - 13:47, 15 August 2024