The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel. Its endogenous ligand is γ-aminobutyric acid (GABA), the major inhibitory...

GABAA-rho receptor (previously known as the GABAC receptor) is a subclass of GABAA receptors composed entirely of rho (ρ) subunits. GABAA receptors including...

In pharmacology, GABAA receptor positive allosteric modulators, also known as GABAkines or GABAA receptor potentiators, are positive allosteric modulator...

of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors); whereas GABAB receptors are G protein-coupled...

and metrazol, and the benzodiazepine GABAA receptor antagonist flumazenil. Other agents which may have GABAA receptor antagonism include the antibiotic ciprofloxacin...

effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABAA receptor, resulting in sedative, hypnotic (sleep-inducing), anxiolytic (anti-anxiety)...

A GABAA receptor negative allosteric modulator is a negative allosteric modulator (NAM), or inhibitor, of the GABAA receptor, a ligand-gated ion channel...

classes of GABA receptor are known: GABAA in which the receptor is part of a ligand-gated ion channel complex GABAB metabotropic receptors, which are G protein-coupled...

GABAA receptor agonist of the imidazopyridine class. It works by increasing GABA effects in the central nervous system by binding to GABAA receptors at...

mushroom. Muscimol is a potent and selective orthosteric agonist for the GABAA receptor and displays sedative-hypnotic, depressant and hallucinogenic psychoactivity...

GABA's effect in the brain, binding to GABA receptors and inhibiting neuronal signaling. GABAA receptor ligands include: Abecarnil Barbiturates (in high...

names in parentheses. EVT-201 – GABAA receptor positive allosteric modulator[1] Lorediplon (GF-015535-00) – GABAA receptor positive allosteric modulator...

GABAA receptor channel is only one of several representatives. This Cys-loop receptor superfamily of ion channels includes the neuronal nACh receptor...

is a neurosteroid and acts as a positive allosteric modulator of the GABAA receptor, the major biological target of the inhibitory neurotransmitter γ-aminobutyric...

and include: GABAA receptors GABAA-ρ receptors The GABAB receptor, a G protein-coupled receptor, is the only metabotropic GABA receptor and its mechanism...

believed to act as an NMDA receptor antagonist and positive allosteric modulator of GABAA receptors. Its activity on those receptors is indirect, unlike that...

electrical activity of neurons by binding to GABAA receptors. There are three main ways the action of the receptor can be classified: relay of signal, amplification...

transmission to reduce anxiety. The GABAA receptor is made up of 5 subunits out of a possible 19, and GABAA receptors made up of different combinations...

antagonists (or inverse agonists) at either the GABAA or glycine receptors, or ionotropic glutamate receptor agonists. Many other drugs may cause convulsions...

stanozolol, and methyltestosterone, have been found to modulate the GABAA receptor similarly to endogenous neurosteroids like allopregnanolone, 3α-androstanediol...

subunit-containing ionotropic glutamate NMDA receptor negative allosteric modulator [47] NORA-520 (brexanolone prodrug) – GABAA receptor positive allosteric modulator...

believed to be GABAA receptor, with particular β subunits playing a crucial role. The concept of specific interactions between receptors and drugs first...

17β-diol – GABAA receptor positive allosteric modulator 3α,5β-Androstanediol (etiocholanediol): 5β-androstane-3α,17β-diol – GABAA receptor positive allosteric...

has been shown to affect ligand-gated ion channels, particularly the GABAA receptor. After oral ingestion, ethanol is absorbed via the stomach and intestines...

dorsal root ganglion neurons despite the presence of GABAA receptors. Glycine and its receptor were first suggested to play a role in inhibition of cells...

acid) – constituent of valerian; has anticonvulsant effects; PAM of the GABAA receptor Derivatives: isovalerate (isopentanoate/3-methylbutanoate), menthyl...

same sites on the GABAA receptor. Menthol may also enhance the activity of glycine receptors and negatively modulate 5-HT3 receptors and nAChRs. Menthol...

mediate their effects: GABAA receptors are chloride channels that hyperpolarize neurons and function as inhibitory CNS receptors. General anesthetics that...

mechanisms of action, both through potentiation of GABAA receptor activity and therefore acting as a GABAA receptor positive allosteric modulator, thereby slowing...

positive allosteric modulators of the GABA type A receptors (GABAA). The GABAA receptors are ligand-gated chloride-selective ion channels that are activated...