Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony-stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages...

production of white blood cells. In contrast to M-CSF and G-CSF which are lineage specific, GM-CSF and its receptor play a role in earlier stages of development...

translation machinery to replicate, it also uses it to make the cell create GM-CSF. GM-CSF is secreted or released when the cancer cell bursts, attracting dendritic...

associated CRS have elevated levels of IL-6, IFN-γ, IL-8 (CXCL8), IL-10, GM-CSF, MIP-1α/β, MCP-1 (CCL2), CXCL9, and CXCL10 (IP-10). The most predictive...

colony stimulating factor (GM-CSF), a critical factor in development of alveolar macrophages. Decreased bioavailability of GM-CSF results in poor alveolar...

factor (GM-CSF). There is some controversy over which granulocytes derive from CFU-GM. There is little disagreement that neutrophils come from CFU-GM. Some...

Leukine) is a recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) that functions as an immunostimulator. Sargramostim is primarily used for...

subunit of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptors in a GM-CSF-dependent human megakaryocytic leukemia cell line (M-07e)"....

of the immune system. In conjunction with other β common chain cytokines GM-CSF and IL-5, IL-3 works to regulate the inflammatory response in order to clear...

Granulocyte colony-stimulating factor (G-CSF or GCSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein that stimulates the bone marrow...

(CSF2)/granulocyte-macrophage colony stimulating factor (GM-CSF). Pre-clinical evidence and clinical data implicate GM-CSF as a crucial initiator in the systemic inflammatory...

interferon gamma (IFNγ), and granulocyte-macrophage colony stimulating factor (GM-CSF) and play an important role in mediating the innate immune response. Inflammatory...

Unlike other members of this cytokine family (namely interleukin 3 and GM-CSF), this glycoprotein in its active form is a homodimer. The IL-5 gene is...

underlying immunopathology: Granulocyte-macrophage colony-stimulating factor (GM‑CSF) Interferon gamma-induced protein 10 (IP‑10) Monocyte chemoattractant protein 1...

colony stimulating factors (e.g. G-CSF and GM-CSF) have long been used in vivo models of MDSC generation. GM-CSF, G-CSF and IL-6 allow the in vitro generation...

factors (CSFs), specifically stimulate the production of committed cells. Three CSFs are granulocyte-macrophage CSF (GM-CSF), granulocyte CSF (G-CSF) and...

colony-stimulating factor (M-CSF) Granulocyte colony-stimulating factor (G-CSF) Granulocyte macrophage colony-stimulating factor (GM-CSF) Epidermal growth factor...

dendritic cells, such as granulocyte-macrophage colony-stimulating factor (GM-CSF). The most common sources of antigens used for dendritic cell vaccine in...

pathways, GM-CSF has been shown to be involved in autoimmune diseases such as multiple sclerosis (MS) and rheumatoid arthritis (RA) in which cases GM-CSF levels...

cells of recombinant murine GM-CSF purified after production in Escherichia coli: comparison with purified native GM-CSF". Journal of Cellular Physiology...

(CD131 or CDw131) is shared between the following type I cytokine receptors: GM-CSF receptor IL-3 receptor IL-5 receptor. The gp130 receptor (Glycoprotein 130)...

colony-stimulating factor (G-CSF), used to treat neutropenia in cancer patients Granulocyte macrophage colony-stimulating factor (GM-CSF), used to treat neutropenia...

used in combination with granulocyte-macrophage colony-stimulating factor (GM-CSF) for people one year of age and older with relapsed or refractory high-risk...

with a marked increase in circulating cytokines, such as IFN-gamma, and GM-CSF. The underlying causative event is unclear, and is the subject of ongoing...

the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF". The EMBO...

infection. G-CSF is used clinically (see Neutropenia) but tests in mice suggest it may lead to bone loss. GM-CSF has been compared to G-CSF as a treatment...

Accutane) and antibody therapy usually administered with the cytokines GM-CSF and IL-2. A meta analysis has found evidence that in children with high-risk...

laherparepvec is the USAN name for the oncolytic virus also known as 'OncoVEX GM-CSF'. It was developed by BioVex Inc. (Woburn, MA, USA & Oxford, UK) until BioVex...

cytokine receptor family (e.g. interferon receptors), the GM-CSF receptor family (IL-3R, IL-5R and GM-CSF-R), the gp130 receptor family (e.g., IL-6R), and the...

chemokines either constitutively (e.g., IL-1 and GM-CSF) or in response to soluble stimuli. TNFα and recombinant GM-CSF for example independently promote IL-10...