known as Grb2, is an adaptor protein involved in signal transduction/cell communication. In humans, the GRB2 protein is encoded by the GRB2 gene. The...
82 KB (9,365 words) - 15:39, 31 March 2024
GAB2 (redirect from GRB2-associated binding protein 2)
GRB2-associated-binding protein 2 also known as GAB2 is a protein that in humans is encoded by the GAB2 gene. GAB2 is a docking protein with a conserved...
26 KB (3,191 words) - 05:41, 17 June 2024
Docking proteins such as GRB2 contain an SH2 domain that binds to the phosphotyrosine residues of the activated receptor. GRB2 binds to the guanine nucleotide...
24 KB (3,068 words) - 07:21, 7 June 2024
GRB2-associated-binding protein 1 is a protein that in humans is encoded by the GAB1 gene. The protein encoded by this gene is a member of the IRS1-like...
13 KB (1,611 words) - 17:10, 22 December 2023
GRB2 associated binding protein 3 is a protein that in humans is encoded by the GAB3 gene. This gene is a member of the GRB2-associated binding protein...
2 KB (272 words) - 15:53, 31 July 2023
adaptor protein Grb2 forms a complex with Sos by the Grb2 SH3 domain. Grb2 (or the Grb2/Sos complex) is recruited to the membrane by the Grb2 SH2 domain binding...
13 KB (1,563 words) - 09:00, 13 March 2024
substrate 2 GAB2 – GRB2-associated binding protein 2 GRAP – GRB2-related adaptor protein GRAP2 – GRB2-related adaptor protein 2 GRB2 – Growth factor receptor-bound...
6 KB (666 words) - 20:46, 24 January 2024
found on Grb2 proteins, allowing them to bind Receptor Tyrosine Kinases (RTKs), and also on SOS proteins allowing them to interact with Grb2. This brings...
1 KB (175 words) - 21:33, 4 October 2016
Adenylyl cyclase Phospholipase C Phospholipase A guanylate cyclase RasGEF (Grb2-Sos) Second messenger cAMP (cyclic adenosine monophosphate) IP3; DAG; Ca2+...
12 KB (1,338 words) - 08:26, 24 July 2023
typically activated by growth hormones through receptor tyrosine kinases and GRB2/SOS, but may also receive other signals. ERKs are known to activate many...
11 KB (1,128 words) - 19:03, 18 September 2023
unable to bind PI3K but is able to bind Grb2 and Gads, gives little NF-κB or IL-2, suggesting that those Grb2 and Gads are unable to compensate for the...
27 KB (3,419 words) - 16:44, 7 May 2024
GRB2-related adapter protein 2 also known as GRB2-related adaptor downstream of Shc (GADS) is a 37 kDa protein that in humans is encoded by the GRAP2...
12 KB (1,459 words) - 15:28, 31 March 2024
signalling, called Grb2, has an SH2 domain, and therefore it can bind to receptors phosphorylated by JAKs (in a similar way to PI3K). Grb2 then functions...
62 KB (6,833 words) - 02:25, 22 June 2024
with: ABI1, BCR gene, CRK, EPS8, Epidermal growth factor receptor, FRS2, Grb2, HRAS, ITSN1, MUC1, NCK1, PLCG1, PTPN11, SH3KBP1, and SHC1. and Son of Sevenless...
32 KB (3,595 words) - 10:04, 27 March 2024
GRB2-related adapter protein is a protein that in humans is encoded by the GRAP gene. This gene encodes a member of the GRB2/Sem5 (C. elegans homolog)/Drk...
5 KB (621 words) - 10:22, 10 January 2024
less clear. HER2/neu has been shown to interact with: CTNNB1, DLG4, Erbin, GRB2, HSP90AA1, IL6ST, MUC1, PICK1 and PIK3R2, PLCG1, and SHC1. SkBr3 Cell Line...
43 KB (4,651 words) - 13:41, 27 July 2024
to interact with: APS, BCR, CD63, CD81, CD9, CRK, CRKL, DOK1, FES, GRB10, Grb2, KITLG, LNK, LYN, MATK, MPDZ, PIK3R1, PTPN11, PTPN6, STAT1, SOCS1, SOCS6...
35 KB (4,117 words) - 14:30, 7 July 2024
pathway, is recruited by the adaptor protein GRB2 in response to EGF receptor activation. The binding of SOS1 to GRB2 localizes it to the plasma membrane, where...
18 KB (2,253 words) - 09:08, 21 October 2023
SH3-containing GRB2-like protein 3-interacting protein 1 is a protein that in humans is encoded by the SGIP1 gene. GRCh38: Ensembl release 89: ENSG00000118473...
4 KB (570 words) - 01:30, 3 January 2024
CAV1, CAV3, CBL, CBLB, CBLC, CD44, CDC25A, CRK, CTNNB1, DCN, EGF, GRB14, Grb2, JAK2, MUC1, NCK1, NCK2 PKC alpha, PLCG1, PLSCR1, PTPN1, PTPN11, PTPN6, PTPRK...
60 KB (6,879 words) - 14:26, 16 July 2024
MS, Yang YC (November 1995). "Interleukin-11 induces complex formation of Grb2, Fyn, and JAK2 in 3T3L1 cells". The Journal of Biological Chemistry. 270...
22 KB (2,508 words) - 16:48, 29 July 2024
BCR protein has been shown to interact with: Abl gene, CD117, CRKL FES, Grb2, GRB10, HCK, MLLT4, PXN, PIK3CG, PTPN6, PTPRT(PTPrho) SOS1, and XPB. Abl...
14 KB (1,541 words) - 16:10, 15 March 2024
HGNC:4562 Q13588 6614 GRAP2 HGNC:4563 O75791 6615 GRAPL HGNC:37240 Q8TC17 6616 GRB2 HGNC:4566 P62993 6617 GRB7 HGNC:4567 Q14451 6618 GRB10 HGNC:4564 Q13322 6619...
277 KB (17 words) - 15:46, 9 May 2024
protein tyrosine kinases and the growth factor receptor bound protein 2 (Grb2). Phosphotyrosine-binding (PTB) domain PTB domains interact with sequences...
74 KB (8,396 words) - 00:09, 26 April 2024
leads to transcription inhibition. CD22 has been shown to interact with Grb2, PTPN6, LYN, SHC1 and INPP5D. GRCm38: Ensembl release 89: ENSMUSG00000030577...
15 KB (1,761 words) - 19:33, 13 July 2024
protein called growth factor-receptor bound protein-2 (Grb2) along with a docking protein called Grb2-associated Binder-1 (GAB1). Subsequently, phosphatidylinositol-3...
24 KB (2,872 words) - 06:27, 22 July 2024
transduction CtBP Yes Transcription factor FIP2 Not known Cell morphogenesis Grb2 Not known Growth factor receptor binding protein HAP1 Yes Membrane trafficking...
30 KB (3,255 words) - 21:36, 6 September 2023
interact with adaptor proteins that have a SH2 domain, and are members of the Grb2 protein family, such as Gads. Moreover, phosphorylation of LAT tyrosine 132...
19 KB (2,288 words) - 20:03, 3 April 2024
bind the LAT/Slp76 complex include: Phospholipase Cγ1 (PLCγ1), SOS via a Grb2 adaptor, Itk, Vav, Nck1 and Fyb. PLCγ is a very important enzyme in the pathway...
43 KB (5,370 words) - 03:09, 26 June 2024
phosphorylate itself. The phosphorylated receptor binds to an adaptor protein (GRB2), which couples the signal to further downstream signaling processes. For...
62 KB (6,781 words) - 14:13, 22 July 2024