Gephyrin is a protein that in humans is encoded by the GPHN gene. This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter...
20 KB (2,486 words) - 06:40, 31 March 2024
microtubule structures. Gephyrin also assists in clustering GABA receptors at synapses and molybdenum cofactor synthesis. Because of gephyrin's multi-functional...
18 KB (1,986 words) - 20:07, 8 October 2024
competitive antagonist of GlyR. Cannabinoids enhance the function. The protein Gephyrin has been shown to be necessary for GlyR clustering at inhibitory synapses...
14 KB (1,546 words) - 19:55, 4 March 2024
localizations that are involved in memory formation. Palmitoylation of gephyrin has been reported to influence GABAergic synapses. DHHC domain Myristoylation...
15 KB (1,591 words) - 05:03, 19 October 2024
Templeton and a team of researchers looked at mutations encompassing the gephyrin gene of chromosome 14 and were able to trace the split back to the last...
6 KB (429 words) - 23:13, 14 September 2022
GABA-receptor-associated protein (GABARAP). Autoantibodies against amphiphysin and gephyrin are also sometimes found in SPS patients. The antibodies appear to interact...
27 KB (2,947 words) - 12:06, 15 September 2024
Carbonetto S, Wiseman PW, Ribeiro-da-Silva A, De Koninck Y (June 2014). "Gephyrin Clusters Are Absent from Small Diameter Primary Afferent Terminals Despite...
17 KB (1,903 words) - 15:52, 27 August 2024
Carbonetto S, Wiseman PW, Ribeiro-da-Silva A, De Koninck Y (June 2014). "Gephyrin Clusters Are Absent from Small Diameter Primary Afferent Terminals Despite...
9 KB (1,019 words) - 15:07, 2 May 2024
identified as a regulator of the localization of gephyrin, inducing the formation of submembrane gephyrin aggregates that accumulate glycine and GABA receptors...
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surface glycine receptors by gephyrin » Nat Neurosci, 4 (3), 2001, 253-260 J. Kirsch, I. Wolters, A. Triller, H. Betz, « Gephyrin Antisense Oligonucleotides...
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al., 2017 find artemisinin itself forces α⇨β conversion in rodents (via gephyrin) and zebrafish while Ackermann et al., 2018 find artesunate does not and...
38 KB (3,972 words) - 06:49, 3 March 2024
newly identified brain-specific GEF, induces submembrane clustering of gephyrin". Nat. Neurosci. 3 (1): 22–9. doi:10.1038/71096. PMID 10607391. S2CID 24878249...
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Buchmeier, S.; Meier, J. C.; Schwarz, G. (2008). "Splice-specific Functions of Gephyrin in Molybdenum Cofactor Biosynthesis". Journal of Biological Chemistry....
75 KB (8,511 words) - 00:53, 29 September 2024
burnout. 4-Iodopropofol GABA receptor GABAB receptor GABAA-ρ receptor Gephyrin Glycine receptor GABAA receptor positive allosteric modulators GABAA receptor...
55 KB (5,956 words) - 21:34, 11 October 2024
synaptic proteins in the post-synaptic density of excitatory synapses, and gephyrin, the respective scaffolding protein of inhibitory post-synapses. In addition...
22 KB (2,569 words) - 08:15, 13 July 2024
Fig 4. GABAergic synapse. The synaptic anchoring protein Gephyrin is indirectly linked to the GABAA receptors....
33 KB (3,684 words) - 20:57, 9 October 2024
Barrow RK, Blackshaw S, et al. (May 1999). "Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling". Science. 284 (5417): 1161–4...
119 KB (12,658 words) - 19:25, 19 September 2024
gamma-aminobutyric acid receptor clustering neuronal signal transduction gephyrin clustering involved in postsynaptic density assembly postsynaptic density...
11 KB (1,321 words) - 15:55, 7 July 2023
number and size of inhibitory postsynaptic complexes like postsynaptic gephyrin clusters. eEF1A has also been found to bind to several kinases, phospholipases...
22 KB (2,672 words) - 20:37, 3 December 2023
biosynthesis, molybendum is incorporated to MPT by the two-domain protein gephyrin. MPT synthase sulfurylase recharges MPT synthase with a sulfur atom after...
11 KB (1,305 words) - 19:13, 28 March 2024
beta". Meyer G, Kirsch J, Betz H, Langosch D (1995). "Identification of a gephyrin binding motif on the glycine receptor beta subunit". Neuron. 15 (3): 563–72...
5 KB (550 words) - 07:49, 6 January 2024
A crosstalk between β1 and β3 integrins controls glycine receptor and gephyrin trafficking at synapses. Nature neuroscience, 13(11), 1388–1395. Charrier...
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(2006). "Neuronal cotransport of glycine receptor and the scaffold protein gephyrin". J. Cell Biol. 172 (3): 441–51. doi:10.1083/jcb.200506066. PMC 2063653...
4 KB (472 words) - 06:53, 28 March 2024
AG, Wang F, St-Louis M, Carbonetto S, Wiseman PW, et al. (June 2014). "Gephyrin clusters are absent from small diameter primary afferent terminals despite...
14 KB (1,615 words) - 14:41, 3 December 2023
Buchmeier, S.; Meier, J. C.; Schwarz, G. (2008). "Splice-specific Functions of Gephyrin in Molybdenum Cofactor Biosynthesis". Journal of Biological Chemistry....
22 KB (2,343 words) - 02:01, 18 September 2024
acid type A receptor (GABAAR)-associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapse". Proceedings...
13 KB (1,678 words) - 20:34, 13 October 2022
(2001). "Fast and reversible trapping of surface glycine receptors by gephyrin". Nature Neuroscience. 4 (3): 253–260. doi:10.1038/85099. PMID 11224541...
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Imamura H, Takahashi K, et al. (February 1998). "Interactions of drebrin and gephyrin with profilin". Biochemical and Biophysical Research Communications. 243...
10 KB (1,100 words) - 02:39, 29 March 2024
Kins S, Rostaing P, El Far O, Kirsch J, Sheng M, et al. (July 2002). "Gephyrin interacts with Dynein light chains 1 and 2, components of motor protein...
7 KB (693 words) - 05:38, 27 September 2024
Biological process neuron cell-cell adhesion cell adhesion signal transduction gephyrin clustering involved in postsynaptic density assembly postsynaptic density...
7 KB (766 words) - 00:36, 4 March 2023