Granzymes are serine proteases released by cytoplasmic granules within cytotoxic T cells and natural killer (NK) cells. They induce programmed cell death...

Granzyme A (GzmA, EC 3.4.21.78, CTLA3, HuTPS, T-cell associated protease 1, cytotoxic T lymphocyte serine protease, TSP-1, T-cell derived serine proteinase)...

Granzyme B (GrB) is one of the serine protease granzymes most commonly found in the granules of natural killer cells (NK cells) and cytotoxic T cells....

Granzyme K (GrK) is a protein that is encoded by the GZMK gene on chromosome 5 in humans. Granzymes are a family of serine proteases which have various...

"Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction"...

increasing the expression of perforin, granzyme B, Fas ligand, and TNF. In monocytes, mTNF has been shown to play a dual role in mediating the monocyte's...

Granzyme B is a serine protease that in humans is encoded by the GZMB gene. Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer...

Gram-positive bacteria. The initial concept of a plasma membrane pore model was challenged when research revealed that granzyme B could undergo endocytosis independently...

required) Jonsson AH, Zhang F, Dunlap G, et al. (June 2022). "Granzyme K+ CD8 T cells form a core population in inflamed human tissue". Science Translational...

associated with the macromolecular complex of granzymes and perforin, and serves as a scaffold for the granzyme and perforin in granule-mediated apoptosis...

Granzyme H is a protein that in humans is encoded by the GZMH gene. GRCh38: Ensembl release 89: ENSG00000100450 – Ensembl, May 2017 GRCm38: Ensembl release...

aortic aneurysm. Other recent research identified Granzyme B (GZMB) (a protein-degrading enzyme) to be a potential target in the treatment of abdominal aortic...

(IP-10, lymphotactin), trigger cytolysis of target cells (perforins, granzymes...), and interact with other cells, such as epithelial cells, monocytes...

collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and Met-ase, also known as granzyme M. GRCh38: Ensembl...

triggered by activated T cells – which secrete toxic granzymes and perforin – or indirectly as a result of reduced blood flow or the generation of reactive...

which are antigenic. Normally, a cytotoxic T cell will immediately come to "inject" lymphotoxins, such as perforin or granzyme, that will kill the infected...

latter's Fc regions interact with their Fc receptors, releasing perforin and granzyme B to kill the tumor cell. Examples include rituximab, ofatumumab, elotuzumab...

American television production company Gamma-ray burst, an astronomical event Granzyme B (GrB), serine protease most commonly found in the granules of NK cells...

protein perforin forms pores in the target cell and provides access for granzymes to enter and trigger cell death by apoptosis. Since 1995, Trapania has...

membrane attack complex. Clusterin, a soluble molecule with functions similar to CD59, forms a complex with Granzyme B and inhibits activation of apoptosis...

as perforin and granzyme B. Flow cytometry is also commonly used. Bone marrow involvement in this disease is often present, but to a variable extent....

Term TSP-1 may refer to: Thrombospondin 1, a protein that in humans in encoded by the THBS1 gene Granzyme A, an enzyme class This disambiguation page lists...

cytokine responses, antibody specific secreting cells, tumor antigens, granzyme B and Perforin release by T cells, vaccine efficacy, epitope mapping, cytotoxic...

by a mixture of benign inflammatory cells. The malignant cells express markers characteristic of NK and/or T cells (e.g. CD2, CD56, CD38), granzyme B,...

macrophages, or neutrophils are the primary cells recruited, release of granzymes and other killing factors if NK cells or neutrophils are recruited, and...

activity due to impaired expression of associated molecules such as IFN-γ, granzyme B or perforin impaired proliferation in response to antigenic stimulation...

cell, and causing it to burst or lyse. CTL release granzyme, a serine protease encapsulated in a granule that enters cells via pores to induce apoptosis...

and granzymes are taken up by the target cell. In this pathway, the perforins facilitate the entry of granule contents into the cell. The granzymes then...

Blockade reduced TNFα and nitric oxide production by macrophages, reduced granzyme B production by NK cells, and decreased proliferation of L. monocytogenes...

secretion of the cytotoxic molecules Granzyme B and Perforin and potentiate T cell receptor dependent IFNγ secretion. A study in mice has shown that IL-10...