Heparanase, also known as HPSE, is an enzyme that acts both at the cell-surface and within the extracellular matrix to degrade polymeric heparan sulfate...
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clots to form. Moreover, most malignant tumors overexpress and secrete heparanase, an enzyme that degrade heparan sulfate and endogenous heparin, and thus...
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Blood group B branched chain alpha-1,3-galactosidase (redirect from Hpa1 heparanase)
Heparanase (EC 3.2.1.166, Hpa1 heparanase, Hpa1, heparanase 1, heparanase-1, C1A heparanase, HPSE) is an enzyme with systematic name heparan sulfate...
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Metastatic breast cancer (section Heparanase)
and nuclear translocation of mitogen-activated protein (MAP) kinases. Heparanase cleaves heparin sulfate chains of HSPGs, which have an extensive network...
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antiadhesive, antimetastatic Phosphomannopentanose sulfate Potent inhibitor of heparanase activity Antimetastatic, antiangiogenic, anti-inflammatory Selectively...
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due to treatment with antineoplastic medications; and (3) secretion of heparanase from malignant tumors that results in degradation of endogenous heparin...
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syndecan-1 only after heparanase modification. Binding utilizes an enzyme-regulated 'off-on' switch in which active epithelial heparanase (HPSE) cleaves off...
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Diagram showing a pancreatic islet and four stages of T1D disease driven by heparanase and loss of intra-islet glycosaminoglycan heparan sulfate (HS)...
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Heparanase-2 is an enzyme that in humans is encoded by the HPSE2 gene. It may be associated with urofacial syndrome. GRCh38: Ensembl release 89: ENSG00000172987...
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2009). "Screening and identification of novel B cell epitopes in human heparanase and their anti-invasion property for hepatocellular carcinoma". Cancer...
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hydrolase family 79 includes endo-beta-N-glucuronidase EC 3.2.1.31 and heparanase (CAZY GH_79). Heparan sulphate proteoglycans (HSPGs) play a key role in...
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a wound. Because heparan sulfate is broken down in chronic wounds by heparanase, the analogues only bind sites where natural heparan sulfate is absent...
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Matzner Y, Cohen IR, Fuks Z, Vlodavsky I (August 1987). "Inhibition of heparanase-mediated degradation of extracellular matrix heparan sulfate by non-anticoagulant...
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cells lacking heparanase after siRNA depletion. Binding was restored by spiking in exogenous heparanase or heparitinase. Thus, heparanase regulates lacritin...
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Trachyspic acid is a fungal isolate that can inhibit heparanase. Shiozawa H, Takahashi M, Takatsu T, Kinoshita T, Tanzawa K, Hosoya T, Furuya K, Takahashi...
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of tissue injury, the soluble syndecan-1 ectodomains are cleaved by heparanases, producing heparin-like fragments that activate bFGF [13]. Whereas most...
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resistance. Masola V, Maran C, Tassone E, Zin A, Rosolen A, Onisto M (2009). "Heparanase activity in alveolar and embryonal rhabdomyosarcoma: implications for...
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Harvard Political Review Hawaii Public Radio Heartland Public Radio HPR1, Heparanase High-power rocketry Highly Protected Risk in insurance; see FM Global...
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viral surfing in herpesviruses. His laboratory was first to implicate heparanase in HSV-1 release and syndecans in HSV-1 entry and cell-to-cell fusion...
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6-β-galactosidase EC 3.2.1.165: exo-1,4-β-D-glucosaminidase EC 3.2.1.166: heparanase EC 3.2.1.167: baicalin-β-D-glucuronidase EC 3.2.1.168: hesperidin...
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expressed in both the central nervous system as well as the bladder. Heparanase 2 is protein coded by exons 8 and 9 on the HPSE2 gene. This protein is...
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identical cells. Heparan sulfate analogues cannot be degraded by all known heparanases and glycanases and bind to the free heparin sulfate binding spots on...
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basic fibroblast growth factor by stromelysin, collagenase, plasmin, and heparanases". The Journal of Biological Chemistry. 271 (17): 10079–10086. doi:10...
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the protein and demonstrating that digestion of the peptide with either heparanase or chondroitinase did not lead to complete loss of the peptide's activity...
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HPSE may refer to: Heparanase, an enzyme Blood group B branched chain alpha-1,3-galactosidase, an enzyme This disambiguation page lists articles associated...
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inflammation, so also in wound areas, heparan sulfates are degraded, mainly by heparanases giving free access to protease to degrade the ECM and a subsequent loss...
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human topoisomerase I inhibitor Trachyspic acid Talaromyces trachyspermus heparanase inhibitor Trichodimerol Trichoderma bio-active pentacycle Ustusolates...
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Andrzej M; Davies, Gideon J (2015). "Structural characterization of human heparanase reveals insights into substrate recognition". Nature Structural & Molecular...
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