Histone deacetylase 2 (HDAC2) is an enzyme that in humans is encoded by the HDAC2 gene. It belongs to the histone deacetylase class of enzymes responsible...
41 KB (4,587 words) - 20:20, 3 December 2023
Histone deacetylase inhibitors (HDAC inhibitors, HDACi, HDIs) are chemical compounds that inhibit histone deacetylases. Since deacetylation of histones...
26 KB (2,977 words) - 17:17, 31 October 2024
Histone deacetylases (EC 3.5.1.98, HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on both histone...
31 KB (3,181 words) - 07:12, 12 August 2024
HDAC1 (redirect from Histone deacetylase 1)
Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the HDAC1 gene. Histone acetylation and deacetylation, catalyzed by multisubunit...
50 KB (5,476 words) - 01:27, 4 January 2024
Histone deacetylase 5 is an enzyme that in humans is encoded by the HDAC5 gene. Histones play a critical role in transcriptional regulation, cell cycle...
17 KB (1,862 words) - 05:58, 6 December 2023
catalysed by enzymes with "histone acetyltransferase" (HAT) or "histone deacetylase" (HDAC) activity. Acetylation is the process where an acetyl functional...
58 KB (7,036 words) - 21:48, 28 February 2024
Mi-2/NuRD (Nucleosome Remodeling Deacetylase) complex, is a group of associated proteins with both ATP-dependent chromatin remodeling and histone deacetylase...
9 KB (1,064 words) - 00:25, 17 May 2024
new antidepressant treatments. Histone deacetylases (HDACs) are a class of enzymes that remove acetyl groups from histones. Different HDACs play different...
35 KB (4,421 words) - 01:52, 22 November 2024
Genetics Histone acetyltransferase Histone deacetylases Histone methyltransferase Histone-modifying enzymes Nucleosome PRMT4 pathway Protamine Histone H1 Youngson...
84 KB (9,582 words) - 18:07, 20 August 2024
increase the effectiveness of radiotherapy. Histone-modifying enzymes Histone deacetylase (HDAC) Histone methyltransferase (HMT) RNA polymerase control...
53 KB (6,150 words) - 04:41, 26 August 2024
Sodium butyrate (category Histone deacetylase inhibitors)
butyrate treatment of cells results in histone hyperacetylation, and butyrate itself inhibits class I histone deacetylase (HDAC) activity, specifically HDAC1...
5 KB (436 words) - 13:46, 24 January 2024
Histone deacetylase 10 is an enzyme that in humans is encoded by the HDAC10 gene. Acetylation of histone core particles modulates chromatin structure and...
7 KB (646 words) - 00:01, 28 November 2023
Givinostat (category Histone deacetylase inhibitors)
is a histone deacetylase inhibitor with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities. It is a histone deacetylase (HDAC)...
16 KB (1,288 words) - 15:34, 8 July 2024
HDAC6 (redirect from Histone deacetylase 6)
Histone deacetylase 6 is an enzyme that in humans is encoded by the HDAC6 gene. HDAC6 has emerged as a highly promising candidate to selectively inhibit...
15 KB (1,738 words) - 07:16, 11 March 2024
Vorinostat (category Histone deacetylase inhibitors)
member of a larger class of compounds that inhibit histone deacetylases (HDAC). Histone deacetylase inhibitors (HDI) have a broad spectrum of epigenetic...
17 KB (1,442 words) - 05:28, 7 May 2024
HDAC3 (redirect from Histone deacetylase 3)
Histone deacetylase 3 is an enzyme encoded by the HDAC3 gene in both humans and mice. Histones are highly alkaline proteins that package and order DNA...
22 KB (2,493 words) - 10:39, 27 December 2023
cofactor interaction. A specific example is the deacetylation by histone deacetylase 2 (HDACe) was necessary for transrepression of NF-κB. The mechanisms...
57 KB (5,143 words) - 05:47, 15 October 2024
properties. Methyl-CpG-binding domain protein 2 has been shown to interact with: GATAD2B, HDAC1, Histone deacetylase 2, MBD3 MIZF, and SIN3A. GRCh38: Ensembl...
12 KB (1,442 words) - 19:46, 3 March 2023
Abexinostat (category Histone deacetylase inhibitors)
types of cancer as well. Abexinostat exerts its effect as a pan-histone deacetylase inhibitor and inhibits RAD51, which is involved in repairing DNA...
9 KB (775 words) - 21:05, 7 July 2024
Trichostatin A (category Histone deacetylase inhibitors)
antibiotic and selectively inhibits the class I and II mammalian histone deacetylase (HDAC) families of enzymes, but not class III HDACs (i.e., sirtuins)...
8 KB (690 words) - 12:36, 1 June 2024
against this protein. CHD4 has been shown to interact with HDAC1, Histone deacetylase 2, MTA2, SATB1 and Ataxia telangiectasia and Rad3 related. Mutations...
13 KB (1,474 words) - 01:41, 26 March 2024
acting as a growth suppressor. The pRb-E2F/DP complex also attracts a histone deacetylase (HDAC) protein to the chromatin, reducing transcription of S phase...
79 KB (9,502 words) - 07:42, 4 September 2024
Pracinostat (category Histone deacetylase inhibitors)
Pracinostat (SB939) is an orally bioavailable, small-molecule histone deacetylase (HDAC) inhibitor based on hydroxamic acid with potential anti-tumor...
3 KB (253 words) - 22:10, 7 March 2022
shown to interact with: CBX1, CBX5, DNMT3A, HDAC1, HDAC3, HDAC9, Histone deacetylase 2, MBD1, RUNX1, Retinoblastoma protein, and SBF1. PIN1 GRCh38: Ensembl...
14 KB (1,636 words) - 23:53, 22 December 2023
Sp3 transcription factor (redirect from SPR-2)
noted. Sp3 transcription factor has been shown to interact with Histone deacetylase 2, PIAS1, E2F1 and GABPA. GRCh38: Ensembl release 89: ENSG00000172845...
4 KB (517 words) - 16:48, 9 April 2024
asthma through the recruitment of histone deacetylase 2(HDAC2) to activated inflammatory genes, thereby reversing the histone acetylation that is involved...
14 KB (1,411 words) - 22:44, 19 November 2024
Histone deacetylase 9 is an enzyme that in humans is encoded by the HDAC9 gene. Histones play a critical role in transcriptional regulation, cell cycle...
20 KB (2,396 words) - 04:11, 8 November 2023
HDAC4 (category Genes on human chromosome 2)
Histone deacetylase 4, also known as HDAC4, is a protein that in humans is encoded by the HDAC4 gene. Histones play a critical role in transcriptional...
19 KB (2,149 words) - 12:19, 11 December 2023
Histone methyltransferases (HMT) are histone-modifying enzymes (e.g., histone-lysine N-methyltransferases and histone-arginine N-methyltransferases),...
19 KB (2,214 words) - 12:18, 4 April 2024
NAD-dependent deacetylase sirtuin 2 is an enzyme that in humans is encoded by the SIRT2 gene. SIRT2 is an NAD+ (nicotinamide adenine dinucleotide)-dependent...
29 KB (3,217 words) - 07:54, 4 November 2024