An imine reductase (IRED) is an enzyme that reduces imines to amines. This family of enzymes is employed in the industrial production of amine-containing...

In organic chemistry, an imine (/ɪˈmiːn/ or /ˈɪmɪn/) is a functional group or organic compound containing a carbon–nitrogen double bond (C=N). The nitrogen...

milder reaction conditions. Investigation into biocatalysts, such as imine reductases, have allowed for higher selectivity in the reduction of chiral amines...

succinaldehyde, followed by loss of water to create an imine Intramolecular addition of the imine to the second aldehyde unit and first ring closure Intermolecular...

conjugation process is illustrated by the metabolism of N-acetyl-p-benzoquinone imine (NAPQI). NAPQI is a reactive metabolite formed by the action of cytochrome...

stability. These biocatalysts, which include amine/alcohol oxidases, imine reductases, lyases, transaminases and monooxygenases, are then applied to the...

protein domain Saccharopine dehydrogenase (SDH), also named Saccharopine reductase, is an enzyme involved in the metabolism of the amino acid lysine, via...

likely involves the generation of an imine, followed by an intramolecular electrophilic aromatic addition of the imine carbon onto the pyrrole ring. And...

secondary and tertiary amines, which nonenzymatically hydrolyze from the imine to aldehyde or ketone. Even though this class of enzyme has been extensively...

building blocks for DNA. This conversion is catalysed by ribonucleotide reductase (see figure). Thiyl intermediates also are produced by the oxidation of...

the enzyme dihydrofolate reductase. Dihydrofolate reductase catalytically activates dihydrofolate by protonating the imine, while NADPH, essentially...

enzymes, such as superoxide dismutase, glutathione peroxidase, glutathione reductase, and catalase. This increase in antioxidant enzyme expression is mediated...

unreactive toward hydroxide. Because the triaminobenzene also exists as its imine tautomer, it is susceptible to hydrolysis. Phloroglucinol is a weak triprotic...

fluorine atom, which converts this catalytic intermediate into a conjugated imine, a highly electrophilic species. This reactive form of DFMO then reacts...

only the amine S-enantiomer to the imine 2 and involving an ammonia–borane reducing couple which can reduce the imine 2 back to the amine 1. In this way...

forming electrophilic alpha and beta unsaturated carbonyl compounds and imines. Some clinical examples of suicide inhibitors include: Disulfiram, which...

saccharopine reductase (E.C 1.5.1.10) catalyses a condensation reaction with glutamate and NAD(P)H, as a proton donor, and the imine is reduced to produce...

which is then decarboxylated via PLP to form agmatine. Hydrolysis of the imine derives N-carbamoylputrescine followed with hydrolysis of the urea to form...

peroxidase-catalyzed reactions that form reactive metabolites (quinone-imines formed from nonconjugated phenolic metabolites) in the bladder. These metabolites...

drink more water per body weight, they have a lower NADH-cytochrome b5 reductase activity, and they have a higher level of fetal hemoglobin which converts...

reductant. The deoxygenation of dimethylsulfoxide is catalyzed by DMSO reductase, a molybdoenzyme: OSMe2 + 2 e− + 2 H+ → SMe2 + H2O The α-CH groups of...

where it exists as a bifunctional enzyme that includes a dihydrofolate reductase domain. A cysteine residue is involved in the catalytic mechanism (it...

ODC was determined to be (S)-((2-(1-pyrroline-methyl) cysteine, a cyclic imine adduct. Presence of this particular product was supported by the possibility...

4 positions. The aldehyde reacts with the diamine to an intermediate di-imine (R−C=N−N=C−R). In the second step, a [3,3]-sigmatropic rearrangement takes...

via a Pictet-Spengler reaction, where the amine group is converted to an imine by deprotonation, then attacks the free aldehyde to form a carbocation that...

in large quantities, a minor metabolite called N-acetyl-p-benzoquinone imine (NAPQI) accumulates within the body. It is normally conjugated by glutathione...

transition structure, wherein both oxygen and nitrogen of the sulfinyl imine coordinate magnesium. Addition of a Grignard reagent to a tert-butanesulfinyl...

Folic acid Dihydrofolate reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed)...

sites: glutathione peroxidase, iodothyronine deiodinase, and thioredoxin reductase. The selenols in these proteins are part of the essential amino acid selenocysteine...

enzyme related to the ammonium monooxygenase family. The formed hydrazine or imine could subsequently be converted by the enzyme hydroxylamine oxidase to dinitrogen...