Retroviral integrase (IN) is an enzyme produced by a retrovirus (such as HIV) that integrates (forms covalent links between) its genetic information into...
12 KB (1,288 words) - 02:08, 1 June 2024
Integrase inhibitors (INIs) are a class of antiretroviral drug designed to block the action of integrase, a viral enzyme that inserts the viral genome...
6 KB (622 words) - 17:42, 23 December 2023
(backward). The new DNA is then incorporated into the host cell genome by an integrase enzyme, at which point the retroviral DNA is referred to as a provirus...
41 KB (4,727 words) - 02:05, 8 September 2024
Site-specific recombination (redirect from Phage integrase)
usually identical, but there are exceptions (e.g. attP and attB of λ integrase). Based on amino acid sequence homologies and mechanistic relatedness...
20 KB (2,034 words) - 07:24, 28 October 2024
version of its genome into the host cell DNA is called its "integrase". HIV-1 integrase catalyzes the “cut-and-paste” action of clipping the host DNA...
16 KB (2,137 words) - 08:40, 9 August 2023
Management of HIV/AIDS (section Integrase inhibitors)
to NNRTIs. Integrase inhibitors (also known as integrase nuclear strand transfer inhibitors or INSTIs) inhibit the viral enzyme integrase, which is responsible...
133 KB (15,784 words) - 05:42, 17 September 2024
It contains bictegravir, a human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor; emtricitabine, an HIV-1 nucleoside analog reverse...
14 KB (1,200 words) - 12:24, 8 October 2024
endowed with an RT (reverse-transcriptase) and an RNAse H domains, and an integrase (IN). Typically, LTR-retrotransposon mRNAs are produced by the host RNA...
24 KB (2,699 words) - 13:53, 25 July 2024
cell nucleus and integrated into the cellular DNA by a virally encoded integrase and host co-factors. Once integrated, the virus may become latent, allowing...
211 KB (21,173 words) - 15:29, 13 November 2024
(insufflation), a method of administrating some medications and vaccines Integrase, a retroviral enzyme In (album), by the Outsiders, 1967 In (Korean name)...
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make development difficult. Integrase is a viral enzyme that integrates retroviral DNA into the host cell genome. Integrase inhibitors are a new class...
32 KB (4,155 words) - 20:03, 9 December 2024
Antiviral drug (section Integrase)
viral RNA. Another target is integrase, which integrate the synthesized DNA into the host cell genome. Examples of integrase inhibitors include raltegravir...
56 KB (6,754 words) - 01:54, 18 December 2024
specific recombination events. The enzyme (38 kDa) is a member of the integrase family of site specific recombinase and it is known to catalyse the site...
15 KB (1,745 words) - 12:21, 16 August 2024
Dolutegravir (category Integrase inhibitors)
breastfeeding is safe. Dolutegravir is an HIV integrase strand transfer inhibitor which blocks the functioning of HIV integrase which is needed for viral replication...
19 KB (1,564 words) - 18:41, 29 November 2024
BI 224436 (redirect from Non-catalytic site integrase inhibitor)
non-catalytic site integrase inhibitor (NCINI). It inhibits HIV replication via binding to a conserved allosteric pocket of the HIV integrase enzyme. This makes...
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Dolutegravir/lamivudine/tenofovir Combination of Dolutegravir Integrase strand transfer inhibitor Lamivudine Nucleoside reverse transcriptase inhibitor...
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analogue RTI Docosanol Herpes Simplex Entry inhibitor Dolutegravir HIV Integrase inhibitor Doravirine (Pifeltro) HIV NNRTI Edoxudine Herpes Simplex Thymidine...
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and architecture. The founding member of the YR family is the lambda integrase, encoded by bacteriophage λ, enabling the integration of phage DNA into...
26 KB (3,200 words) - 20:41, 26 March 2024
nucleus and integrated into the cellular DNA by a virally encoded enzyme, integrase, and host co-factors. Once integrated, the virus may become latent, allowing...
124 KB (14,115 words) - 13:49, 1 December 2024
The WHO Model List of Essential Medicines (aka Essential Medicines List or EML), published by the World Health Organization (WHO), contains the medications...
67 KB (4,835 words) - 02:06, 4 December 2024
integron platform by site-specific recombination reactions mediated by the integrase. Integrons were initially discovered on conjugative plasmids through their...
10 KB (1,132 words) - 04:40, 19 December 2024
use in children, and agreed to negotiate a license for dolutegravir, an integrase inhibitor then in clinical development. In 2014, this license was extended...
139 KB (12,483 words) - 15:11, 13 December 2024
Academica integrase no Club of Pioneers Archived 16 March 2022 at the Wayback Machine Académica-oaf.pt, 4 November 2017 Academica integrase no Club of...
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Cabotegravir/rilpivirine (category Integrase inhibitors)
resistance to non-nucleoside reverse transcriptase inhibitors (NNRTIs) and integrase strand transfer inhibitors. Cabotegravir/rilpivirine must not be combined...
15 KB (1,230 words) - 02:38, 16 July 2024
(cDNA). The cDNA is integrated into the host cell's genome by the enzyme integrase, which causes the host cell to generate viral proteins that reassemble...
59 KB (6,894 words) - 20:05, 18 November 2024
longer available) Attachment inhibitors fostemsavir (brand name Rukobia) Integrase strand transfer inhibitors (INSTIs): dolutegravir (brand name Tivicay)...
8 KB (606 words) - 01:32, 26 July 2024
Viruses can also contain enzymes for infecting cells, such as the HIV integrase and reverse transcriptase, or for viral release from cells, like the influenza...
97 KB (9,890 words) - 18:35, 2 December 2024
theoretical physicist Daria Hazuda, 1989, biochemist; discovered the first HIV Integrase Strand Transfer Inhibitors Carl Heastie, 1990, Speaker of the New York...
153 KB (13,912 words) - 12:07, 19 December 2024
early stages of genome replication, and include reverse transcriptase and integrase. Reverse transcriptase is the virally encoded RNA-dependent DNA polymerase...
16 KB (1,770 words) - 20:38, 20 September 2024
Raltegravir (category Integrase inhibitors)
breastfeeding is safe. Raltegravir is an HIV integrase strand transfer inhibitor which blocks the functioning of HIV integrase which is needed for viral replication...
18 KB (1,461 words) - 05:52, 19 November 2024