In biochemistry, isozymes (also known as isoenzymes or more generally as multiple forms of enzymes) are enzymes that differ in amino acid sequence but...

Clinical data Trade names Coricidin 'D' Pharmacokinetic data Metabolism CYP2D6 isozyme of Cytochrome P450 Identifiers CAS Number 125-71-3 Y UNII 7355X3ROTS...

yeast S. cerevisiae only encodes one catalytic subunit, mammals have four isozymes encoded by three genes, each attracting a different set of regulatory subunits...

erythrocytes and aldolase C is expressed in the brain. Slight differences in isozyme structure result in different activities for the two substrate molecules:...

19-kD Ca2+-binding regulatory subunit, calcineurin B. There are three isozymes of the catalytic subunit, each encoded by a separate gene (PPP3CA, PPP3CB...

hypoxia. Notably, hypoxia only induces expression of the muscle isozyme and not the liver isozyme. However, muscle-specific glycogen synthase activation may...

coded for by different alleles at the same locus. These are opposed to isozymes, which are enzymes that perform the same function, but which are coded...

discovered cyclooxygenase (COX3050) isozyme, while the first two to be discovered were COX-1 and COX-2. The COX-3 isozyme is encoded by the same gene as COX-1...

prostaglandin-endoperoxide synthase (PTGS), is an enzyme (specifically, a family of isozymes, EC 1.14.99.1) that is responsible for biosynthesis of prostanoids, including...

concentration of the active form. This chiral shift is accomplished by the CYP2C19 isozyme of cytochrome P450, which is not found equally in all human populations...

Hexosaminidase (EC 3.2.1.52, β-acetylaminodeoxyhexosidase, N-acetyl-β-D-hexosaminidase, N-acetyl-β-hexosaminidase, N-acetyl hexosaminidase, β-hexosaminidase...

contrast, GWS was inversely associated with higher levels of the type Q isozyme, which is more efficient at breaking down sarin than its type R counterpart...

receptor. Tramadol is metabolised in the liver via the cytochrome P450 isozyme CYP2B6, CYP2D6, and CYP3A4, being O- and N-demethylated to five different...

effects of these medications. Fluoxetine and norfluoxetine inhibit many isozymes of the cytochrome P450 system that are involved in drug metabolism. Both...

and the lower Tilemsi valley in Mali (2500 to 2000 cal BC). Studies of isozymes suggest domestication took place north east of the Senegal River in the...

Ubiquitin-activating enzymes, also known as E1 enzymes, catalyze the first step in the ubiquitination reaction, which (among other things) can target a...

mitochondrial matrix. The other liver isozyme, ALDH1, localizes to the cytosol. Most White people have both major isozymes, while approximately 36% of East...

The L and R isozymes are expressed by the gene PKLR, whereas the M1 and M2 isozymes are expressed by the gene PKM2. The R and L isozymes differ from M1...

C-terminal beta-sheet domain Crystal structure of barley alpha-amylase isozyme 1 (amy1) inactive mutant d180a in complex with maltoheptaose Identifiers...

has grown with the development of isozyme-selective PDE inhibitors that offer potent inhibition of selected isozymes without the side-effects attributed...

deactivation. There are four known isozymes of PDK in humans: PDK1 PDK2 PDK3 PDK4 The primary sequencing between the four isozymes are conserved with 70% identity...

Glycogenin is an enzyme involved in converting glucose to glycogen. It acts as a primer, by polymerizing the first few glucose molecules, after which other...

Different enzymes that catalyze the same chemical reaction are called isozymes.: 10.3  The International Union of Biochemistry and Molecular Biology have...

generating ADP and 1,3-BPG. In humans, two isozymes of PGK have been so far identified, PGK1 and PGK2. The isozymes have 87-88% identical amino acid sequence...

hours. It is metabolized in the liver via the cytochrome P450 oxidase isozyme CYP2C19, excreted by the kidneys and has about an eight-hour half-life...

the cytochrome P450 oxidase enzyme system (particularly by the CYP1A2 isozyme) into three dimethylxanthines, each of which has its own effects on the...

to the steroid receptors. The human genome encodes two distinct HSD-11β isozymes (HSD-11β Type 1 and HSD-11β Type 2) on distinct genes. The dehydrogenase...

Olanzapine is metabolized by the cytochrome P450 (CYP) system; principally by isozyme 1A2 (CYP1A2) and to a lesser extent by CYP2D6. By these mechanisms, more...

Pharmacokinetic data Bioavailability 60–70% Metabolism Liver, by several CYP isozymes Elimination half-life 4–26 hours (mean value 14.2 hours in steady state...

in animals, phosphoenolpyruvate carboxykinase. The latter exists as an isozyme located in both the mitochondrion and the cytosol. The rate of gluconeogenesis...