potassium channel protein whose primary subunit in humans is encoded by the KCNQ1 gene. It's mutation causes Long QT syndrome, Kv7.1 is a voltage and lipid-gated...

known for modulating the cardiac and epithelial Kv channel alfa subunit, KCNQ1. KCNQ1 and KCNE1 form a complex in human ventricular cardiomyocytes that generates...

syndrome, responsible for 30 to 35% of all cases. The gene responsible, KCNQ1, has been isolated to chromosome 11p15.5 and encodes the alpha subunit of...

KCNQ1 downstream neighbour (KCNQ1DN) is a long non-coding RNA gene. In humans, it is located on chromosome 11p15.5 between the CDKN1C and KCNQ1 genes...

KCNQ1 overlapping transcript 1, also known as KCNQ1OT1, is a long non-coding RNA gene found in the KCNQ1 locus. This locus consists of 8–10 protein-coding...

(SUDC). Many of the genes are involved in long QT syndrome. Mutations in the KCNQ1 gene that codes for the voltage-gated potassium channel KV7.1 have been...

syndrome, responsible for 30 to 35% of all cases. The gene responsible, KCNQ1, has been isolated to chromosome 11p15.5 and encodes the alpha subunit of...

Jervell and Lange-Nielsen syndrome is caused by mutations in the KCNE1 and KCNQ1 genes. The proteins produced by these two genes work together to form a...

PMID 16267222. Rivas, A; Francis, H. W (2005). "Inner ear abnormalities in a Kcnq1 (Kvlqt1) knockout mouse: A model of Jervell and Lange-Nielsen syndrome"...

for protons as it acidifies the stomach. While KCNQ1 channels are inhibited by low extracellular pH, KCNQ1-KCNE2 channels activity is augmented by extracellular...

KCNE4 inhibition of KCNQ1 requires calmodulin, which binds to both KCNQ1 and KCNE4. KCNE4 can also inhibit complexes formed by KCNQ1 and KCNE1. KCNE4 has...

channel ancillary or β subunits. KCNE3 is best known for modulating the KCNQ1 Kv α subunit, but it also regulates hERG, Kv2.1, Kv3.x, Kv4.x and Kv12.2...

family members of the Kv7 potassium channel family. These include Kv7.1 (KCNQ1) - KvLQT1, Kv7.2 (KCNQ2), Kv7.3 (KCNQ3), Kv7.4 (KCNQ4), and Kv7.5 (KCNQ5)...

CaV1.2 CACNA1C 0-2 K+ Ito1 KV4.2/4.3 KCND2/KCND3 1, notch K+ IKs KV7.1 KCNQ1 2,3 K+ IKr KV11.1 (hERG) KCNH2 3 K+ IK1 Kir2.1/2.2/2.3 KCNJ2/KCNJ12/KCNJ4...

(KCNB2) Kvα3.x - Shaw-related: Kv3.1 (KCNC1), Kv3.2 (KCNC2) Kvα7.x: Kv7.1 (KCNQ1) - KvLQT1, Kv7.2 (KCNQ2), Kv7.3 (KCNQ3), Kv7.4 (KCNQ4), Kv7.5 (KCNQ5) Kvα10...

(KCNB2) Kvα3.x - Shaw-related: Kv3.1 (KCNC1), Kv3.2 (KCNC2) Kvα7.x: Kv7.1 (KCNQ1) - KvLQT1, Kv7.2 (KCNQ2), Kv7.3 (KCNQ3), Kv7.4 (KCNQ4), Kv7.5 (KCNQ5) Kvα10...

responsible for the delayed rectifier potassium current IKr  SQT2 609621 KCNQ1 Kv7.1 Encodes the potassium channel responsible for the delayed rectifier...

actually resides within a Kcnq1 sense exon. Similar to HOTAIR (see above), Eed-Ezh2 Polycomb complexes are recruited to the Kcnq1 loci paternal chromosome...

fast and irregular. It is associated with multiple genes: Mutations in the KCNQ1 gene cause familial atrial fibrillation. The KCNE2 and KCNJ2 genes are associated...

HGNC:6291 Q9H2S1 8049 KCNN3 HGNC:6292 Q9UGI6 8050 KCNN4 HGNC:6293 O15554 8051 KCNQ1 HGNC:6294 P51787 8052 KCNQ2 HGNC:6296 O43526 8053 KCNQ3 HGNC:6297 O43525...

channels, abbreviated Kv7.2. The KCNQ gene subfamily consists of five members (KCNQ1–5), all encoding voltage-gated potassium (K+) channel subunits (Kv7.1–5)...

PMID 21874019. Sun J, MacKinnon R (January 2020). "Structural Basis of Human KCNQ1 Modulation and Gating". Cell. 180 (2): 340–347.e9. doi:10.1016/j.cell.2019...

be linked to interactions between diet and the FTO and KCNQ1 genes. Mutations within the KCNQ1 gene affects a pathway that leads to a decrease in insulin...

KCNJ11, NOTCH2, WFS1, IGF2BP2, SLC30A8, JAZF1, HHEX, DGKB, CDKN2A, CDKN2B, KCNQ1, HNF1A, HNF1B MC4R, GIPR, HNF4A, MTNR1B, PPARG, ZBED3, SLC30A8, CDKAL1,...

channel which is formed of two subunits, the KCNE1 regulatory protein and the KCNQ1 channel proteins.[8] This channel provides the pathway through which K+...

voltage-gated Na+ channel SCN5A Cardiac and epithelial K+ channels KCNE1/KCNQ1 Voltage-gated K+ channels Kv1.3, Kv1.5, and Kv4.3 Glutamate Receptors The...

related decline in acetylcholine release. Linopirdine also blocks homomeric KCNQ1 and KCNQ4 voltage gated potassium channels which contribute to vascular...

macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel". Science. 295 (5554): 496–9. Bibcode:2002Sci.....

against a panel of cardiac ion channels (hERG, Nav1.5, L type channels, and KCNQ1) and no activity on GABAA gated channels at 10 μM. A range of related benzamides...

is taken and tested. The molecular autopsy focuses on four main genes: KCNQ1, KCNH2, SCN5A, and RYR2. Greater than 95% of the mutations found in the...