known as lysine (K)-specific demethylase 1A (KDM1A) is a protein that in humans is encoded by the KDM1A gene. LSD1 is a flavin-dependent monoamine oxidase...
17 KB (2,086 words) - 19:22, 5 January 2024
histone half-life. Histone lysine demethylase LSD1 (later classified as KDM1A) was first identified in 2004 as a nuclear amine oxidase homolog. Two main...
25 KB (3,087 words) - 22:52, 3 December 2023
is a dual inhibitor of the enzymes lysine-specific demethylase 1 (LSD1; KDM1A) and monoamine oxidase B (MAO-B) which is under development for the treatment...
7 KB (427 words) - 04:06, 7 November 2024
developed to inhibit the human enzyme lysine-specific demethylase-1 (LSD1 or KDM1A EC:1.14.99.66), an oxidating enzyme that mediates demethylation of lysine...
11 KB (1,083 words) - 21:25, 9 November 2024
and the activation of cell fate genes. Lysine specific demethylase 1 (KDM1A) is thought to prevent the use of enhancer regions of pluripotency genes...
50 KB (6,030 words) - 16:44, 2 October 2024
HGNC:6305 P33947 8086 KDELR3 HGNC:6306 O43731 8087 KDF1 HGNC:26624 Q8NAX2 8088 KDM1A HGNC:29079 O60341 8089 KDM1B HGNC:21577 Q8NB78 8090 KDM2A HGNC:13606 Q9Y2K7...
277 KB (17 words) - 18:41, 6 October 2024
(multifunctional DNA repair enzyme) 1 (APEX1), lysine (K)-specific demethylase 1A (KDM1A), trans-golgi network protein 2 (TGOLN2), and tripartite motif containing...
11 KB (718 words) - 10:05, 10 March 2024
Maki Kobayashi-Osak; Masayuki Yamamoto; Makoto Kobayashia (2015). "LSD1/KDM1A promotes hematopoietic commitment of hemangioblasts through downregulation...
8 KB (898 words) - 07:18, 9 October 2024
targets many transcription factors KAT5 targets many nuclear receptors KDM1A targets androgen receptors Steroid receptor coactivator (SRC) family NCOA1...
18 KB (1,698 words) - 10:42, 3 December 2023
pole of cytoskeleton, and ER-Golgi intermediate compartment membrane), and KDM1A (in the nucleus). Another proposed interaction between TEX9 involves attachment...
17 KB (1,202 words) - 09:52, 11 August 2024
N-methyltransferase (SUV39H2), and lysine-specific histone demethylase 1A (KDM1A). In a study of the genes expressed in lung squamous cell carcinomas it...
10 KB (820 words) - 13:16, 21 April 2024
Llombart-Bosch A, Kovar H (August 2012). "Lysine-specific demethylase 1 (LSD1/KDM1A/AOF2/BHC110) is expressed and is an epigenetic drug target in chondrosarcoma...
111 KB (12,533 words) - 04:42, 11 August 2024
Khavari, Paul A. (15 September 2014). "ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes...
19 KB (1,802 words) - 14:54, 15 July 2024
methylation, CCDC74A has been shown to interact with the lysine demethylase KDM1A through a yeast 2-hybrid assay. Additionally, through a yeast 2-hybrid assay...
12 KB (1,231 words) - 16:44, 10 October 2023
from the presence of a serine or threonine that could be phosphorylated. KDM1A, a lysine-specific demethylase, was shown to be physically associated with...
16 KB (1,503 words) - 15:31, 2 November 2024
these targets, LSD1 (Lysine-specific histone demethylase 1A, also known as KDM1A) has been shown to be directly downregulated by miR-137 via binding to its...
17 KB (2,115 words) - 02:41, 29 March 2024