Ku70 is a protein that, in humans, is encoded by the XRCC6 gene. Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand...

of the non-homologous end joining DNA repair pathway, including DNA-PKcs, Ku70/Ku80 and DNA ligase IV assembled with topo IIβ and PARP-1. This assemblage...

bound to each other). Eukaryotic Ku is a heterodimer of two polypeptides, Ku70 (XRCC6) and Ku80 (XRCC5), so named because the molecular weight of the human...

protein called Ku70. It has previously been reported that Ku70 migrates to the host cell surface in the presence of "Rickettsia". Then, Ku70 is ubiquitinated...

107 years of age had higher levels of two DNA repair enzymes, PARP1 and Ku70, than general-population old individuals of 69 to 75 years of age. Their...

bridging during mammalian NHEJ. Eukaryotic Ku is a heterodimer consisting of Ku70 and Ku80, and forms a complex with DNA-PKcs, which is present in mammals...

hXRCC4, with the aid of Cernunnos-XLF. DNA-PKcs and hXRCC4 are anchored to Ku70 / Ku80 heterodimer, which are bound to the DNA ends. Since hXRCC4 is the...

Kmo (kynurenine 3-monoxygenase), loqs (loquacious), r2d2 (r2d2 protein), ku70 (ku heterodimer protein gene) and lig4 (ligase4) were targeted to modify...

enzymes of the non-homologous end joining (NHEJ) DNA repair pathway (DNA-PKcs, KU70, KU80, and DNA LIGASE IV) (see Figure). These enzymes repair the double-strand...

PMID 8628283. Boulton SJ, Jackson SP (September 1996). "Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier...

Ku80 is a protein that, in humans, is encoded by the XRCC5 gene. Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break...

transcription factors, including ACTR, cMyb, E2F1, EKLF, FEN 1, GATA, HNF-4, HSP90, Ku70, NFκB, PCNA, p53, RB, Runx, SF1 Sp3, STAT, TFIIE, TCF, and YY1. The ketone...

a protoplast. It was found that disrupting (knockout or RNAi silencing) ku70 homologue can increase gene targeting via increased homologous recombination...

KT65 — May 27, 2000 Anderson Mesa LONEOS  · 4.8 km MPC · JPL 165135 2000 KU70 — May 28, 2000 Socorro LINEAR  · 6.5 km MPC · JPL 165136 2000 KN74 — May...

enzymes of the non-homologous end joining (NHEJ) DNA repair pathway (DNA-PKcs, KU70, KU80 and DNA LIGASE IV) (see figure). These enzymes repair the double-strand...

PMID 27136939. Li H, Vogel H, Holcomb VB, Gu Y, Hasty P (2007). "Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer"...

Granzyme B. Substrates of GzmA include Pro-IL-1β, NDUFS3, SET, APE1, and Ku70 among others. In vitro studies suggest that GzmA may have less cytotoxic...

mechanism. Examples include: ACTR, cMyb, E2F1, EKLF, FEN 1, GATA, HNF-4, HSP90, Ku70, MKP-1, NF-κB, PCNA, p53, RB, Runx, SF1 Sp3, STAT, TFIIE, TCF, YY1, etc....

has also been observed to acetylate c-MYC, GATA-2, retinoblastoma (Rb), Ku70, and E1A adenovirus protein. It can also autoacetylate, which facilitates...

Telomerase reverse transcriptase has been shown to interact with: HSP90AA1, Ku70, Ku80, MCRS1, Nucleolin, PINX1, and YWHAQ. PAWR telomerase reverse transcriptase...

H3K9ac, H1K26ac, H4K16ac Hif-1α, Hif-2α, MYC, P53, BRCA1, FOXO3A, MyoD, Ku70, PPARγ, PCAF, Suv39h1, TGFB1, WRN, NBS1 Neurodegenerative diseases, Cancer:...

double strand breaks. In Co-Immunoprecipitation experiments, MRI-2 bound to Ku70 and Ku80, two subunits of Ku, which play a major role in the NHEJ pathway...

been initiated instead of NHEJ. In contrast, the presence of a Ku complex (Ku70 and Ku80) indicates that NHEJ has been initiated instead of HDR. HDR and...

followed by religation of the DNA strands. To initiate whole process, the Ku70/80 protein complex binds to the damaged ends of the DSB strands. This forms...

2009). "Interleukin-6 affects cell death escaping mechanisms acting on Bax-Ku70-Clusterin interactions in human colon cancer progression". Cell Cycle. 8...

apparently leads to cancer. MRE11 has been shown to interact with: ATM, BRCA1, Ku70, MDC1, NBN, Rad50, and TERF2. Homologous recombination GRCh38: Ensembl release...

encoding enzyme probable tubulin polyglutamylase TTLL1 XRCC6: encoding protein Ku70 The following diseases are some of those related to genes on chromosome 22:...

helicase E1A E2F Elk1 ER Ets1 Fen1 Foxo1 Gal4 GATA1 GR hATF4 HNF-1 Hif-1α Ku70   MDM2 MLL MyoD NF-κB p53 p73 Parp1 pCREB pCAF PCNA Pit1 RAR RXR SCRAP SMAD...

replaced with F (phenylalanine). TERF2 has also been shown to interact with: Ku70, MRE11A, Nibrin and Rad50, RE1-silencing transcription factor, TERF2IP, Werner...

Queseth S, Fornander T, Askmalm MS (December 2010). "Low expression of Ku70/80, but high expression of DNA-PKcs, predict good response to radiotherapy...