Ku is a dimeric protein complex that binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair...
15 KB (1,695 words) - 15:03, 17 January 2023
Look up ku in Wiktionary, the free dictionary. Ku, KU, or Kū may refer to: Ku (fictional language), a constructed language created for the 2005 film The...
4 KB (541 words) - 08:45, 1 June 2024
independent from classical NHEJ and does not rely on NHEJ core factors such as Ku protein, DNA-PK, or Ligase IV. In MMEJ, repair of the DSB is initiated by end...
11 KB (1,373 words) - 22:13, 6 February 2023
Ku80 is a protein that, in humans, is encoded by the XRCC5 gene. Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand...
21 KB (2,612 words) - 05:45, 11 June 2024
NS1 (section Non-structural protein 1)
NS 1, NS-1, NS.1, or variation, may refer to: NS1 influenza protein NS1 dengue protein, used for NS1 antigen test Human bocavirus NS1 Carnivore bocaparvovirus...
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RNF8 (category RING finger proteins)
homologous recombination repair. Ku protein is a dimeric protein complex, a heterodimer of two polypeptides, Ku70 and Ku80. Ku protein forms a ring structure....
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not depend on a second homologous chromosome. This pathway requires the Ku protein and a specialized poly-functional ATP-dependent DNA ligase (ligase D)...
18 KB (2,149 words) - 18:24, 28 June 2024
the nucleus.[citation needed] The finding that WRN protein interacts with DNA-PKcs and the Ku protein complex, combined with evidence that WRN deficient...
36 KB (4,516 words) - 03:55, 13 August 2024
serine/threonine protein kinase called DNA-PK. The second component is the autoimmune antigen Ku. On its own, DNA-PKcs is inactive and relies on Ku to direct...
33 KB (3,807 words) - 02:32, 6 August 2024
cancers, and atherosclerosis. The finding that WRN protein interacts with DNA-PKcs and the Ku protein complex, combined with evidence that WRN deficient...
54 KB (6,763 words) - 11:47, 18 April 2024
Non-homologous end-joining factor 1 (redirect from XLF Protein)
XRCC4, and with Ku protein, and it can also interact weakly with DNA. Co-crystal structures of XLF and XRCC4 suggest that the two proteins can form hetero-oligomers...
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not increased in the mutant mice. Ku70 and Ku80 form the heterodimer Ku protein essential for the non-homologous end joining (NHEJ) pathway of DNA repair...
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Werner syndrome helicase (redirect from WRN protein)
enzymatic and non-enzymatic functions. At DSBs, in association with Ku (protein), it promotes standard or canonical NHEJ (c-NHEJ), repairing double-strand...
30 KB (3,671 words) - 03:03, 5 August 2024
ADP-ribosylation (section Protein degradation)
and serves to activate PARP1. The PARPs have many protein targets at the site of DNA damage. KU protein and DNA-PKcs are both double-stranded break repair...
29 KB (3,535 words) - 13:23, 4 January 2024
ps1701s35. PMC 7162418. PMID 18429251. Linderstrøm-Lang KU (1952). Lane Medical Lectures: Proteins and Enzymes. Stanford University Press. p. 115. ASIN B0007J31SC...
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first bound to by Ku protein complexes that trigger the phosphorylation of NHEJ initiation factors such as DNA-PK (DNA-dependent protein kinase) and PARP...
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DNA repair protein XRCC4 (hXRCC4) also known as X-ray repair cross-complementing protein 4 is a protein that in humans is encoded by the XRCC4 gene. XRCC4...
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NHEJ in which all of the required activities are contained in only two proteins: a Ku homodimer and the multifunctional ligase/polymerase/nuclease LigD. In...
28 KB (3,679 words) - 19:28, 3 December 2023
Endoplasmic reticulum (section Protein transport)
of the eukaryotic cell, and has many other important functions such as protein folding. It is a type of organelle made up of two subunits – rough endoplasmic...
34 KB (3,710 words) - 08:29, 7 July 2024
Polycomb-group proteins (PcG proteins) are a family of protein complexes first discovered in fruit flies that can remodel chromatin such that epigenetic...
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in 2008 by using a strain that lacked nonhomologous end joining proteins (Ku (protein), known in Podospora as PaKu70). This method claimed to have 100%...
22 KB (2,529 words) - 11:40, 12 August 2024
RecQ helicase (category Protein pages needing a picture)
additional exonuclease activity. WRN interacts with DNA-PKcs and the Ku protein complex. This observation, combined with evidence that WRN deficient cells...
17 KB (1,883 words) - 02:48, 12 July 2024
Papillomaviridae (redirect from E6 – protein)
Przysiecki CT, Cook JC, Lehman ED, Sands JA, Jansen KU, Keller PM (February 1999). "The L1 major capsid protein of human papillomavirus type 11 recombinant virus-like...
63 KB (7,242 words) - 05:09, 15 April 2024
Philadelphia chromosome (redirect from Bcr-abl fusion protein)
region BCR gene of chromosome 22, coding for a hybrid protein: a tyrosine kinase signaling protein that is "always on", causing the cell to divide uncontrollably...
29 KB (3,538 words) - 15:01, 5 December 2023
Keratin (section Protein structure)
Keratin (/ˈkɛrətɪn/) is one of a family of structural fibrous proteins also known as scleroproteins. Alpha-keratin (α-keratin) is a type of keratin found...
39 KB (3,016 words) - 15:08, 13 July 2024
Gokiso Station, in Shōwa-ku, Nagoya, Aichi Prefecture, Japan Hamacho Station, in Chūō, Tokyo, Japan Hoshimi Station, in Teine-ku, Sapporo, Hokkaido, Japan...
2 KB (363 words) - 06:11, 20 November 2022
CRISPR (redirect from CRISPR associated protein)
genomes and nearly 90% of sequenced archaea. Cas9 (or "CRISPR-associated protein 9") is an enzyme that uses CRISPR sequences as a guide to recognize and...
128 KB (13,448 words) - 03:26, 19 August 2024
biomolecules ranging from approximately < 1 ku to greater than 30 ku (e.g., metal chaperones, prions, metal transport proteins, amyloids, metalloenzymes, metallopeptides...
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Ku70 is a protein that, in humans, is encoded by the XRCC6 gene. Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand...
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ETS1 (section DNA repair protein interactions)
[where the DNA-PK complex is made up of DNA-PKcs and DNA repair Ku (protein), and where Ku itself is a heterodimer of two polypeptides, Ku70 (XRCC6) and...
13 KB (1,811 words) - 03:47, 21 August 2023