Ku is a dimeric protein complex that binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair...

Look up ku in Wiktionary, the free dictionary. Ku, KU, or Kū may refer to: Ku (fictional language), a constructed language created for the 2005 film The...

independent from classical NHEJ and does not rely on NHEJ core factors such as Ku protein, DNA-PK, or Ligase IV. In MMEJ, repair of the DSB is initiated by end...

Ku80 is a protein that, in humans, is encoded by the XRCC5 gene. Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand...

NS 1, NS-1, NS.1, or variation, may refer to: NS1 influenza protein NS1 dengue protein, used for NS1 antigen test Human bocavirus NS1 Carnivore bocaparvovirus...

homologous recombination repair. Ku protein is a dimeric protein complex, a heterodimer of two polypeptides, Ku70 and Ku80. Ku protein forms a ring structure....

not depend on a second homologous chromosome. This pathway requires the Ku protein and a specialized poly-functional ATP-dependent DNA ligase (ligase D)...

the nucleus.[citation needed] The finding that WRN protein interacts with DNA-PKcs and the Ku protein complex, combined with evidence that WRN deficient...

serine/threonine protein kinase called DNA-PK. The second component is the autoimmune antigen Ku. On its own, DNA-PKcs is inactive and relies on Ku to direct...

cancers, and atherosclerosis. The finding that WRN protein interacts with DNA-PKcs and the Ku protein complex, combined with evidence that WRN deficient...

XRCC4, and with Ku protein, and it can also interact weakly with DNA. Co-crystal structures of XLF and XRCC4 suggest that the two proteins can form hetero-oligomers...

not increased in the mutant mice. Ku70 and Ku80 form the heterodimer Ku protein essential for the non-homologous end joining (NHEJ) pathway of DNA repair...

enzymatic and non-enzymatic functions. At DSBs, in association with Ku (protein), it promotes standard or canonical NHEJ (c-NHEJ), repairing double-strand...

and serves to activate PARP1. The PARPs have many protein targets at the site of DNA damage. KU protein and DNA-PKcs are both double-stranded break repair...

ps1701s35. PMC 7162418. PMID 18429251. Linderstrøm-Lang KU (1952). Lane Medical Lectures: Proteins and Enzymes. Stanford University Press. p. 115. ASIN B0007J31SC...

first bound to by Ku protein complexes that trigger the phosphorylation of NHEJ initiation factors such as DNA-PK (DNA-dependent protein kinase) and PARP...

DNA repair protein XRCC4 (hXRCC4) also known as X-ray repair cross-complementing protein 4 is a protein that in humans is encoded by the XRCC4 gene. XRCC4...

NHEJ in which all of the required activities are contained in only two proteins: a Ku homodimer and the multifunctional ligase/polymerase/nuclease LigD. In...

of the eukaryotic cell, and has many other important functions such as protein folding. It is a type of organelle made up of two subunits – rough endoplasmic...

Polycomb-group proteins (PcG proteins) are a family of protein complexes first discovered in fruit flies that can remodel chromatin such that epigenetic...

in 2008 by using a strain that lacked nonhomologous end joining proteins (Ku (protein), known in Podospora as PaKu70). This method claimed to have 100%...

additional exonuclease activity. WRN interacts with DNA-PKcs and the Ku protein complex. This observation, combined with evidence that WRN deficient cells...

Przysiecki CT, Cook JC, Lehman ED, Sands JA, Jansen KU, Keller PM (February 1999). "The L1 major capsid protein of human papillomavirus type 11 recombinant virus-like...

region BCR gene of chromosome 22, coding for a hybrid protein: a tyrosine kinase signaling protein that is "always on", causing the cell to divide uncontrollably...

Keratin (/ˈkɛrətɪn/) is one of a family of structural fibrous proteins also known as scleroproteins. Alpha-keratin (α-keratin) is a type of keratin found...

Gokiso Station, in Shōwa-ku, Nagoya, Aichi Prefecture, Japan Hamacho Station, in Chūō, Tokyo, Japan Hoshimi Station, in Teine-ku, Sapporo, Hokkaido, Japan...

genomes and nearly 90% of sequenced archaea. Cas9 (or "CRISPR-associated protein 9") is an enzyme that uses CRISPR sequences as a guide to recognize and...

biomolecules ranging from approximately < 1 ku to greater than 30 ku (e.g., metal chaperones, prions, metal transport proteins, amyloids, metalloenzymes, metallopeptides...

Ku70 is a protein that, in humans, is encoded by the XRCC6 gene. Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand...

[where the DNA-PK complex is made up of DNA-PKcs and DNA repair Ku (protein), and where Ku itself is a heterodimer of two polypeptides, Ku70 (XRCC6) and...