Lanosterol is a tetracyclic triterpenoid and is the compound from which all animal and fungal steroids are derived. By contrast, plant steroids are produced...
6 KB (305 words) - 03:31, 19 August 2024
cation and finally to lanosterol. Lanosterol is a key four-ringed intermediate in cholesterol biosynthesis. In humans, lanosterol synthase is encoded by...
22 KB (2,582 words) - 17:29, 3 April 2024
are manufactured in cells from the sterols lanosterol (opisthokonts) or cycloartenol (plants). Lanosterol and cycloartenol are derived from the cyclization...
82 KB (8,473 words) - 08:47, 30 August 2024
Lanosterol 14α-demethylase (CYP51A1) is the animal version of a cytochrome P450 enzyme that is involved in the conversion of lanosterol to 4,4-dimethylcholesta-8(9)...
10 KB (1,066 words) - 05:53, 15 December 2023
the conversion of squalene to lanosterol. In fungi, lanosterol is then converted to ergosterol; in humans, lanosterol becomes cholesterol. However, as...
20 KB (1,758 words) - 22:15, 3 August 2024
intermediate in the synthesis of the cell membrane sterol precursors lanosterol and cycloartenol, as well as saponins. It is formed when squalene is oxidized...
3 KB (97 words) - 06:26, 12 July 2024
Similarly to other azole fungicides, prochloraz is an inhibitor of the enzyme lanosterol 14α-demethylase (CYP51A1), which is necessary for the production of ergosterol...
6 KB (398 words) - 07:32, 26 November 2023
(vitamin E), dolichols, and squalene. Heme A has an isoprenoid tail, and lanosterol, the sterol precursor in animals, is derived from squalene and hence from...
17 KB (1,703 words) - 16:36, 21 July 2024
Synthase 1), and CYP51A1, lanosterol 14-α-demethylase, sometimes unofficially abbreviated to LDM according to its substrate (Lanosterol) and activity (DeMethylation)...
15 KB (1,669 words) - 19:11, 3 September 2024
Rimocidin Azole antifungals inhibit the conversion of lanosterol to ergosterol by inhibiting lanosterol 14α-demethylase. These compounds have a five-membered...
28 KB (2,588 words) - 11:09, 26 August 2024
cycloartenol Lanosterol synthase (LAS), found in all animals and fungi, and occasionally in plants, which produces primarily lanosterol Sterols and triterpenes...
19 KB (2,196 words) - 19:46, 4 July 2024
synthesis of ergosterol from lanosterol by interfering with 14α-demethylase. Ergosterol is a smaller molecule than lanosterol; it is synthesized by combining...
11 KB (983 words) - 00:00, 15 August 2024
14,24(28)-trien-3beta-ol, formate, NADP+, and H2O. Although the lanosterol 14α-demethylase is present in a wide variety of organisms, the enzyme...
14 KB (1,517 words) - 11:47, 8 June 2024
Fluconazole (category Lanosterol 14α-demethylase inhibitors)
binding, while still allowing binding of the enzyme's natural substrate, lanosterol. Development of resistance to one azole in this way will confer resistance...
31 KB (2,821 words) - 10:58, 27 May 2024
from lanosterol. Ergosterol is absent in animals but is an essential component of the cell membranes of many fungi and protozoa, and so lanosterol 14α-demethylase...
37 KB (2,107 words) - 17:27, 8 June 2024
step towards cholesterol biosynthesis. Squalene leads to the creation of lanosterol, from which there are multiple pathways that lead to cholesterol biosynthesis...
56 KB (6,560 words) - 23:49, 7 July 2024
Diethylpropanediol Ethylene glycol Trialcohols Glycerol Sterols Cholesterol Ergosterol Lanosterol β-Sitosterol Stigmasterol Fluoroalcohols 1,3-Difluoro-2-propanol 2,2,2-Trifluoroethanol...
21 KB (2,054 words) - 22:25, 13 August 2024
along with the known phytoconstituents lauric acid, β-sitosterol and lanosterol. Marshmallows are used in gardening as ornamental plants. The leaves,...
11 KB (1,227 words) - 06:42, 6 August 2024
steps. This is followed by 19 additional steps to convert the resulting lanosterol into cholesterol. A human male weighing 68 kg (150 lb) normally synthesizes...
80 KB (8,530 words) - 16:20, 22 August 2024
3-oxidosqualene. It then undergoes an enzyme-catalysed cyclisation to produce lanosterol, which can be elaborated into other steroids such as cholesterol and ergosterol...
19 KB (1,761 words) - 01:30, 14 June 2024
Barry (1968). Studies of the mechanism of action of 2,3-oxidosqualene-lanosterol cyclase: featuring enzymic cyclization of modified squalene oxides (Ph...
13 KB (1,022 words) - 18:26, 2 July 2024
Cultivated chaga developed a reduced number of phytosterols, particularly lanosterol, an intermediate in the synthesis of ergosterol and lanostane-type triterpenes...
11 KB (1,093 words) - 05:45, 28 July 2024
Tocopherols Cholesterol Testosterone Cholecalciferol Ecdysones Other Betulin Lanosterol Saponins Serratenediol Squalane Acids Oleanolic acid Ursolic acid Betulinic...
19 KB (1,534 words) - 16:11, 26 August 2024
squalene and then folded up and formed into a set of rings to make lanosterol. Lanosterol can then be converted into other steroids such as cholesterol and...
71 KB (7,373 words) - 16:15, 8 August 2024
Clotrimazole (category Lanosterol 14α-demethylase inhibitors)
component of the fungal cell membrane, by inhibiting the P450 enzyme lanosterol 14-alpha demethylase. Clotrimazole may slow fungal growth or result in...
18 KB (1,454 words) - 01:33, 8 August 2024
cucurbitane core, although in practice they are biosynthesised from either lanosterol (animals and fungi) or cycloartenol (plants) via the cyclization of squalene...
5 KB (509 words) - 14:51, 30 April 2023
the steroids of fungi and animals, which are, instead, produced from lanosterol. The biosynthesis of cycloartenol starts from the triterpenoid squalene...
3 KB (150 words) - 03:57, 19 August 2024
squalene and then folded up and formed into a set of rings to make lanosterol. Lanosterol can then be converted into other sterols such as cholesterol and...
113 KB (12,400 words) - 18:04, 20 August 2024
pyrophosphate. Squalene is then processed biosynthetically to generate either lanosterol or cycloartenol, the structural precursors to all the steroids. Sesquarterpenes...
32 KB (3,485 words) - 02:54, 22 August 2024
Itraconazole (category Lanosterol 14α-demethylase inhibitors)
inhibits the fungal-mediated synthesis of ergosterol, via inhibition of lanosterol 14α-demethylase. Because of its ability to inhibit cytochrome P450 3A4...
26 KB (2,397 words) - 16:07, 20 May 2024