organisms, Mef2 proteins mediate the stress response in some tissues. Mef2 proteins contain both MADS-box and Mef2 DNA-binding domains. Mef2 was originally...
15 KB (1,906 words) - 15:38, 29 November 2023
humans is encoded by the MEF2C gene. MEF2C is a transcription factor in the Mef2 family. The gene is located at 5q14.3 on the minus (Crick) strand and is...
15 KB (1,887 words) - 23:41, 11 November 2023
Fxn in the nervous system in mice also activates an iron/sphingolipid/PDK1/Mef2 pathway, indicating that the mechanism is evolutionarily conserved. Furthermore...
25 KB (2,774 words) - 16:47, 24 September 2024
factor part of the MEF2 gene family including MEF2A, MEF2C, and MEF2D. However, MEF2B is distant from the other three branches of MEF2 genes as it lacks...
10 KB (1,114 words) - 04:31, 10 August 2024
humans is encoded by the MEF2A gene. MEF2A is a transcription factor in the Mef2 family. In humans it is located on chromosome 15q26. Certain mutations in...
12 KB (1,449 words) - 08:55, 30 March 2022
Myocyte-specific enhancer factor 2A, NFATC2 Sp1 transcription factor, and YWHAQ. Mef2 GRCh38: Ensembl release 89: ENSG00000116604 – Ensembl, May 2017 GRCm38: Ensembl...
11 KB (1,265 words) - 19:51, 12 May 2022
MAPKAP kinase 2 and to phosphorylate the transcription factors ATF2, Mac, MEF2, and p53. p38 also has been shown to phosphorylate post-transcriptional regulating...
14 KB (1,385 words) - 10:32, 28 April 2024
enhancer factor 2 (MEF2), host cell factor (HCF), and others. It also has a positive feedback loop, enhancing its own expression. Both MEF2 and cAMP response...
65 KB (7,149 words) - 14:04, 13 November 2024
factor MEF2". Science. 286 (5440): 790–3. doi:10.1126/science.286.5440.790. PMID 10531067. Youn HD, Liu JO (Jul 2000). "Cabin1 represses MEF2-dependent...
9 KB (1,080 words) - 11:37, 4 March 2023
(CtBP), myocyte enhancer factor 2 (MEF2) and 14-3-3. All three HDACs work to repress the myogenic transcription factor MEF2 which an essential role in muscle...
58 KB (7,036 words) - 21:48, 28 February 2024
slow-type muscle proteins in cooperation with myocyte enhancer factor 2 (MEF2) proteins and other regulatory proteins. Ca2+/calmodulin-dependent protein...
119 KB (13,834 words) - 10:47, 10 November 2024
factors – reside in the nucleus regardless of activation state – CREB, AP-1, Mef2 II.B.3.b latent cytoplasmic factors – inactive form reside in the cytoplasm...
74 KB (8,192 words) - 09:41, 10 November 2024
CNTN3, SCN7A, and RNF8. Several of these genes appeared to be targets of MEF2, one of the transcription factors known to be regulated by neuronal activity...
114 KB (10,913 words) - 08:01, 25 October 2024
family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group...
24 KB (2,820 words) - 05:34, 10 July 2024
family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group...
124 KB (13,220 words) - 11:01, 30 August 2024
family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group...
57 KB (6,672 words) - 01:42, 9 October 2024
model suggested that this gene may be regulated directly or indirectly by MEF2 site binding proteins. Heritability of autism Morrow EM, Yoo SY, Flavell...
1 KB (94 words) - 03:16, 22 March 2024
MCM1) domain. MEF2-like MADS-domain proteins in animals and fungi have the MEF2 domain as a second conserved domain. In plants, the MEF2-like MADS-domain...
17 KB (1,908 words) - 16:47, 3 December 2023
family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group...
22 KB (2,646 words) - 05:40, 13 July 2024
family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group...
41 KB (4,385 words) - 21:28, 21 August 2024
This process includes mitogen-activated protein kinases and binding of the MEF2 transcription factor within the promoter region of the myostatin gene. Increases...
48 KB (5,338 words) - 23:42, 9 November 2024
can also directly block the association of MEF2 with GRIP-1, a transcription co-activator, which inhibits MEF2’s ability to induce muscle gene expression...
25 KB (2,805 words) - 03:43, 6 May 2024
family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group...
39 KB (4,859 words) - 19:32, 22 August 2024
elav-Gal4/UAS-Flp or Cre system to express the recombinase specifically in neurons and a Mef2-Gal4/UAS-Flp or Cre system to express it specifically in muscles. The authors...
21 KB (2,655 words) - 10:31, 15 May 2024
Furlong, EE (June 2006). "A temporal map of transcription factor activity: mef2 directly regulates target genes at all stages of muscle development". Developmental...
24 KB (1,976 words) - 21:51, 4 October 2024
factors (e.g., myoD and myogenin) and gene transcription factors (e.g., MEF2). HMB-induced human myosatellite cell proliferation in vitro is mediated...
106 KB (9,982 words) - 15:37, 7 January 2024
later arise from satellite cells. Two genes significant in muscle fusion are Mef2 and the twist transcription factor. Studies have shown knockouts for Mef2C...
24 KB (2,738 words) - 02:09, 3 September 2024
family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group...
41 KB (4,468 words) - 17:08, 21 September 2024
family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group...
26 KB (3,172 words) - 03:27, 3 December 2023
family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group...
33 KB (3,818 words) - 23:33, 17 August 2024