MUTYH (mutY DNA glycosylase) is a human gene that encodes a DNA glycosylase, MUTYH glycosylase. It is involved in oxidative DNA damage repair and is part...
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MUTYH-associated polyposis (also known as MYH-associated polyposis) is an autosomal recessive polyposis syndrome. The disorder is caused by mutations...
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chromosome 5 while autosomal recessive FAP (or MUTYH-associated polyposis) is caused by defects in the MUTYH gene on chromosome 1. Of the three, FAP itself...
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cancer syndromes are ataxia–telangiectasia, Bloom syndrome, Fanconi anemia, MUTYH-associated polyposis, Rothmund–Thomson syndrome, Werner syndrome and Xeroderma...
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associated with base excision repair (BER) deficiency and linked to defective MUTYH, a DNA glycosylase, in colorectal cancer. Direct DNA oxidation damage leads...
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MYH can refer to: An alternative name for MUTYH, a gene that causes colon polyps when mutated. Muslim Youth Helpline, a charity helpline that provides...
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H. T.; Lanspa, S. J. (2010). "Colorectal Cancer Survival Advantage in MUTYH-Associated Polyposis and Lynch Syndrome Families". JNCI Journal of the National...
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studies the proteins MUTYH and NEIL1, which help to catalyze the repair of damaged DNA as part of the base excision repair pathway. MUTYH is a glycosylase...
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HT, Lanspa SJ (November 2010). "Colorectal cancer survival advantage in MUTYH-associated polyposis and Lynch syndrome families". Journal of the National...
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instability. Additional implicated genes include SMAD4, BMPR1A, PTEN, GREM1, and MUTYH. The only validated genetic cause of SPS is germline mutations in RNF43...
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help exclude similar syndromes, such as Familial adenomatous polyposis and MUTYH-associated polyposis. Endometrial cancer, duodenal polyps and duodenal cancer...
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Birt–Hogg–Dubé syndrome Cowden syndrome Cronkhite–Canada syndrome Juvenile polyposis MUTYH Peutz–Jeghers syndrome Herold, Gerd (2012). Innere Medizin : eine vorlesungsorientierte...
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protein), alpha 1, DLG3, KIFAP3, MAPRE2, JUP, SIAH1, TFAP2A, TUBA4A and XPO1. MUTYH GRCm38: Ensembl release 89: ENSMUSG00000005871 – Ensembl, May 2017 "Human...
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reductase (NADPH) MUL1: Mitochondrial E3 ubiquitin protein ligase 1 MUTYH (1p34): mutY homolog (E. coli) NBPF3: Neuroblastoma breakpoint family member...
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GADD45A GADD45G HDAC1 HUS1 ING1 KCTD13 KIAA0101 Ku70 Ku80 MCL1 MSH3 MSH6 MUTYH P21 POLD2 POLD3 POLDIP2 POLH POLL RFC1 RFC2 RFC3 RFC4 RFC5 Ubiquitin C Werner...
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Hübscher U, Janscak P (2012). "Involvement of Werner syndrome protein in MUTYH-mediated repair of oxidative DNA damage". Nucleic Acids Res. 40 (17): 8449–59...
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This allows WRN to promote long-patch DNA repair synthesis by Polλ during MUTYH-initiated repair of 8-oxo-G:A mispairs. WRN is also involved in replication...
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Q96NY9 10058 MUSK HGNC:7525 O15146 10059 MUSTN1 HGNC:22144 Q8IVN3 10060 MUTYH HGNC:7527 Q9UIF7 10061 MVB12A HGNC:25153 Q96EY5 10062 MVB12B HGNC:23368...
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Hübscher U, Janscak P (2012). "Involvement of Werner syndrome protein in MUTYH-mediated repair of oxidative DNA damage". Nucleic Acids Res. 40 (17): 8449–59...
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Kuśnierczyk A, et al. (December 2015). "Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice" (PDF). Cell Reports...
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identification of a potential causative mutation affecting expression of MUTYH". Genomics. 97 (2): 121–129. doi:10.1016/j.ygeno.2010.11.006. PMID 21126570...
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Buisine MP (2006). "Low frequency of AXIN2 mutations and high frequency of MUTYH mutations in patients with multiple polyposis". Hum. Mutat. 27 (10): 1064...
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gene; all encode the same protein. APEX1 has been shown to interact with MUTYH, Flap structure-specific endonuclease 1 and XRCC1. Deficiency of APEX1 causes...
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A1 has been shown to interact with: BRCA2, BLM, MCM2, MCM4, MCM6, MCM7, MUTYH, ORC2L, ORC6L, P53, RPA2, RPA3, TIPIN, TP53BP1, and XPA. DNA-binding subunit...
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identification of a potential causative mutation affecting expression of MUTYH". Genomics. 97 (2): 121–129. doi:10.1016/j.ygeno.2010.11.006. PMID 21126570...
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about 50 target genes to increase expression, including DNA repair genes MUTYH, BARD1, ERCC1 and XPA. Increased ETS1 expression causes resistance to cell...
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of defective mutations in either the APC (adenomatous polyposis coli) or MUTYH gene. These mutations lead to several abnormalities in the regulation of...
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Hirahashi M, Kumagae Y, Nakamura M, Oki E, Oda Y (June 2016). "Reduced MUTYH, MTH1, and OGG1 expression and TP53 mutation in diffuse-type adenocarcinoma...
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ovarian, somatic; 604370; PRKN Adenomas, multiple colorectal; 608456; MUTYH Adenomas, salivary gland pleomorphic; 181030; PLAG1 Adenomatous polyposis...
234 KB (18,877 words) - 15:43, 9 May 2024