NLR family pyrin domain containing 3 (NLRP3) (previously known as NACHT, LRR, and PYD domains-containing protein 3 [NALP3] and cryopyrin), is a protein...

which includes seven NLRP3 molecules. NLRP3 has been recognized as the largest inflammasome, with a diameter of around 2 um. NLRP3 oligomerization is activated...

and activate proinflammatory process and production of IL-1β and IL-18. NLRP3 (contains three domain: pyrin domain, a nucleotide-binding domain and a...

Dapansutrile (OLT1177) is an inhibitor of the NLRP3 (nucleotide-binding domain leucine-rich repeat and pyrin domain containing receptor 3) inflammasome...

There are three well-characterized inflammasomes – NLRP1, NLRP3 and IPAF. The formation of NLRP3 inflammasome can be activated by PAMPs such as microbial...

initially prime an inflammatory response by increasing expression of NLRP3 (signal 1). NLRP3 will become active once the cell receives an additional "activation...

activate the NLRP3 inflammasome. Kanneganti discovered that Influenza A virus, Candida, and Aspergillus specifically activate the NLRP3 inflammasome and...

would acquire Jecure Therapeutics, gaining access to Jecure's portfolio of NLRP3 inhibitors developed to fight inflammatory diseases like non-alcoholic steatohepatitis...

acute kidney injury. Finally, DAMPs also promote renal fibrosis by inducing NLRP3, which also promotes TGF-β receptor signaling. Seong SY, Matzinger P (June...

response to aluminum in adjuvants. NLRP3 is involved in the immune response to toxins in the environment. For example, NLRP3 is activated to form an inflammasome...

NLRC4 can recognise flagellin and type III secretion system components. NLRP3 is activated by cellular events induced by different PAMPs and DAMPs stimuli...

experimentally to inhibit release of interleukin 1 beta from the NALP3 (or NLRP3) inflammasome. Sulfonylureas – as opposed to metformin, the thiazolidinediones...

amyloidosis) 191900 NLRP3 CAPS: Familial cold urticaria 120100 NLRP3 CAPS: Neonatal onset multisystem inflammatory disease (NOMID) 607115 NLRP3 Periodic fever...

cascade. The mutation in NLRP3 leads to aberrant constitutive formation of this inflammasome. Up to 170 heterogenous mutations in NLRP3 have been identified...

reactions. The NLRP3-containing inflammasome forms in response to danger signals (e.g., LPS, pathogens, etc.). These signals cause cytosolic NLRP3 (i.e., NLR...

cryopyrin-associated periodic syndromes (CAPS) caused by mutations in the CIAS1/NALP3 (aka NLRP3) gene at location 1q44. The effect of FCAS on the quality of life of patients...

reaction in macrophages, which is initiated by the NLRP3 inflammasome protein complex. Activation of the NLRP3 inflammasome recruits the enzyme caspase 1, which...

Muckle-Wells syndrome occurs when a mutation in the NLRP3 gene leads to increased activity of the protein NLRP3 (cryopyrin). This protein is partly responsible...

pyroptosis in human nasal epithelial cells, which is mediated by the NOD1/2/TLR4/NLRP3 pathway. Furthermore, it has been discovered that children with adenoid...

(called NLRP1 to NLRP14). NLRP3 and NLRP4 are responsible for the inflammasome activation. NLRP3 can be activated and give rise to NLRP3 inflammasome by ATP...

ISSN 0065-2598. PMID 27734407. Latz, Eicke; Duewell, Peter (1 December 2018). "NLRP3 inflammasome activation in inflammaging". Seminars in Immunology. 40: 61–73...

clinically relevant periods. Silica crystals inside the lungs can activate the NLRP3 inflammasome inside macrophages and dendritic cells and thereby result in...

against thioacetamide-induced hepatic damage in Wistar rat: investigation on NLRP3, MMP-2, and stellate cell activation". Naunyn-Schmiedeberg's Archives of...

against thioacetamide-induced hepatic damage in Wistar rat: investigation on NLRP3, MMP-2, and stellate cell activation". Naunyn-Schmiedeberg's Archives of...

Watremez W, Fasolino V, et al. (August 2016). "Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models"....

Feigenbaum L, et al. (May 2011). "Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin-1β activation and severe autoinflammation...

Stress by regulating oxidative stress and inflammation associated with the NLRP3 gene. Maianthemum Search for "Polygonatum", World Checklist of Selected...

Cholesterol crystals are believed to induce inflammation by activation of the NLRP3 inflammasome. In addition to being a source of inflammation, cholesterol...

is highly activated in patients with Parkinson's disease by NLRP3 inflammasome. The NLRP3 inflammasome reacts to synuclein containing protein clumps by...

Leucine Rich Repeat NLRP3 will sense an efflux of potassium ions from the cell. This cellular ion imbalance leads to oligomerisation of NLRP3 molecules to form...