is a Bronsted acid and its conjugate base, the orotate anion, is able to bind to metals. Lithium orotate, for example, has been investigated for use in...

Lithium orotate (C5H3LiN2O4) is a salt of orotic acid and lithium. It is available as the monohydrate, LiC5H3N2O4·H2O. In this compound, lithium is non-covalently...

Magnesium orotate, the magnesium salt of orotic acid, is a mineral supplement. It can be used in treating extracellular magnesium deficiency, as well...

Orotate phosphoribosyltransferase (OPRTase) or orotic acid phosphoribosyltransferase is an enzyme involved in pyrimidine biosynthesis. It catalyzes the...

The enzyme Uridine monophosphate synthase (EC 4.1.1.23, UMPS) (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase) catalyses the formation...

latter is converted to orotate by dihydroorotate oxidase. The net reaction is: (S)-Dihydroorotate + O2 → Orotate + H2O2 Orotate is covalently linked with...

chloride Magnesium gluconate Magnesium glycinate Magnesium lactate Magnesium orotate Magnesium oxide Magnesium pidolate Injected Magnesium sulfate Laxative...

In enzymology, an orotate reductase (NADPH) (EC 1.3.1.15) is an enzyme that catalyzes the chemical reaction (S)-dihydroorotate + NADP+ ⇌ {\displaystyle...

In enzymology, an orotate reductase (NADH) (EC 1.3.1.14) is an enzyme that catalyzes the chemical reaction (S)-dihydroorotate + NAD+ ⇌ {\displaystyle...

the roots of certain plants, such as Leguminosae. Magnesium supplements orotate, oxide, sulfate, citrate, and glycerate are all structurally similar. However...

called orotate is synthesized independently of PRPP. After orotate is made it is covalently attached to PRPP. This results in a nucleotide called orotate monophosphate...

enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein...

of uridine monophosphate. OMP is formed from orotate and phosphoribosyl pyrophosphate by the enzyme orotate phosphoribosyltransferase. In humans, the enzyme...

1017-fold increase in rate over the uncatalysed reaction in the case of orotate decarboxylase (78 million years without the enzyme, 18 milliseconds with...

converts N-Carbamoylaspartate to orotate. Orotate is covalently linked with phosphoribosyl pyrophosphate (PRPP) by orotate phosphoribysol-transferase yielding...

Thomas D. (2007). "Ternary Complex Formation and Induced Asymmetry in Orotate Phosphoribosyltransferase". Biochemistry. 46 (49): 14075–14086. doi:10...

5-phosphoribosyl-1-pyrophosphate to orotate to form OMP. In organisms utilizing OMP decarboxylase, this reaction is catalyzed by orotate phosphoribosyltransferase...

nervous system in a variety of ways. While the citrate, carbonate, and orotate salts are currently used to treat bipolar disorder, other lithium salts...

catalyzed by orotidylate decarboxylase. The orotidylate is produced from orotate, which is combined with 5-phosphoribosyl-1-pyrophosphate (PRPP) to form...

A12CC07 Magnesium levulinate A12CC08 Magnesium pidolate A12CC09 Magnesium orotate A12CC10 Magnesium oxide A12CC30 Magnesium (different salts in combination)...

membrane, oxidizes dihydroorotate to orotate. Orotate phosphoribosyl hydrolase (OMP pyrophosphorylase) condenses orotate with PRPP to form orotidine-5'-phosphate...

attached to ribose throughout the process. Pyrimidine ring is synthesized as orotate and attached to ribose phosphate and later converted to common pyrimidine...

tetrahydrofolate. Pyrimidines, on the other hand, are synthesized from the base orotate, which is formed from glutamine and aspartate. All organisms are constantly...

antacids and laxatives. Magnesium chloride, oxide, gluconate, malate, orotate, glycinate, ascorbate and citrate are all used as oral magnesium supplements...

under ultraviolet light. Pyrimidine biosynthesis creates derivatives —like orotate, thymine, cytosine, and uracil— de novo from carbamoyl phosphate and aspartate...

domain Dihydroorotate dehydrogenases Oxidation of dihydroorotate (DHO) to orotate. Biosynthesis of pyrimidine nucleotides in prokaryotic and eukaryotic cells...

synthesis, PRPP covalently links to orotate at the one-position carbon on the ribose unit. The reaction is catalyzed by orotate phosphoriboseyltransferase (PRPP...

reaction (S)-dihydroorotate + fumarate ⇌ {\displaystyle \rightleftharpoons } orotate + succinate This enzyme contains FMN. Björnberg O, Rowland P, Larsen S...

localized in the mitochondria. UMPS is a bifunctional enzyme consisting of orotate phosphoribosyltransferase (OPRT) and orotidine monophosphate decarboxylase...

Electrolytes replacement Magnesium supplements (e.g. magnesium citrate, orotate, Maalox, etc.) Potassium supplements (e.g. chloride potassium with citrate...