Orotic acid (/ɔːˈrɒtɪk/) is a pyrimidinedione and a carboxylic acid. Historically, it was believed to be part of the vitamin B complex and was called...

synthesis pathway. Orotic aciduria is characterized by excessive excretion of orotic acid in urine because of the inability to convert orotic acid to UMP. It...

Orotate phosphoribosyltransferase (OPRTase) or orotic acid phosphoribosyltransferase is an enzyme involved in pyrimidine biosynthesis. It catalyzes the...

4,5-Dihydroorotic acid is a derivative of orotic acid which serves as an intermediate in pyrimidine biosynthesis. Lacroute F (March 1968). "Regulation...

synthesis can lead to the genetic disease Orotic aciduria which causes excessive excretion of orotic acid in the urine. Nucleotides are initially made...

5-Fluoroorotic acid (5FOA) is a fluorinated derivative of the pyrimidine precursor orotic acid. It is used in yeast genetics to select for the absence...

Magnesium orotate, the magnesium salt of orotic acid, is a mineral supplement. It can be used in treating extracellular magnesium deficiency, as well...

block is proximal to these intermediates) and increased orotic acid. The increased orotic acid concentrations result from the buildup of carbamoyl phosphate...

pattern. OTC deficiency is also accompanied by hyperammonemia and high orotic acid levels. BUN is usually reported in mg/dL in some countries (e.g. United...

carbamoyl-phosphate in the cytoplasm to the common precursor ring structure orotic acid, onto which a phosphorylated ribosyl unit is covalently linked. Purines...

Lithium orotate (C5H3LiN2O4) is a salt of orotic acid and lithium. It is available as the monohydrate, LiC5H3N2O4·H2O. In this compound, lithium is non-covalently...

uridine monophosphate synthetic pathway. Orotic acid is a product of this pathway. Increased levels of orotic acid in urine can be an indicator that a patient...

PMID 2767686. Traut TW, Jones ME (1996). Uracil metabolism--UMP synthesis from orotic acid or uridine and conversion of uracil to beta-alanine: enzymes and cDNAs...

of chess Moseley, a suburb of Birmingham, England, from its postcode Orotic acid, formerly known as Vitamin B13 Boron-13 (B-13 or 13B), an isotope of...

result in orotic aciduria, a metabolic disorder. In a study, gerbils fed a combination of uridine monophosphate, choline, and docosahexaenoic acid (DHA) were...

5-Dihydroorotic acid Orotic acid. Note the double bond in the ring. The particular mechanism for the dehydrogenation of dihydroorotic acid by DHODH differs...

ornidazole (INN) Ornidyl ornipressin (INN) ornithine (INN) ornoprostil (INN) orotic acid (INN) orotirelin (INN) orpanoxin (INN) orphenadrine (INN) Orphengesic...

Orotidine is a nucleoside formed by attaching orotic acid to a ribose ring via a β-N1-glycosidic bond. It is found in bacteria, fungi and plants. It was...

folate ("pteroylmonoglutamic acid" in this nomenclature). Vitamin B13: orotic acid. Vitamin B14: cell proliferant, anti-anemia, rat growth factor, and antitumor...

lacking orotidine-5'-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance". Mol. Gen. Genet. 197 (2): 345–6. doi:10.1007/bf00330984...

2013. Retrieved 4 November 2013. Chester, DO (1979). "Three New Aliphatic Acids from Lichens of Genus Parmelia (Subgenus Xanthoparmelia )". Australian Journal...

1879, when Grimaux reported the preparation of barbituric acid from urea and malonic acid in the presence of phosphorus oxychloride. The systematic study...

lacking orotidine-5'-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance". Mol Gen Genet. 197 (2): 345–346. doi:10.1007/BF00330984...

C5H4N2O pyrazinecarboxaldehyde 5780-66-5 C5H4N2O2 pyrazinoic acid 98-97-5 C5H4N2O4 orotic acid 65-86-1 C5H4N4 pyridotetrazole 274-87-3 C5H4N4O allopurinol...

"Enzymatic synthesis and breakdown of a pyrimidine, orotic acid. I. Dihydroortic acid, ureidosuccinic acid, and 5-carboxymethylhydantoin" (PDF). The Journal...

the presence of the condition: Plasma ammonia concentration. Urinary orotic acid concentration Red blood cell arginase enzyme activity (measurement) The...

syndrome, levels of alanine, orotic acid and homocitrulline may be elevated as well. In people with hyperammonemia orotic acid and homocitrulline appear...

effective in accomplishing enzymatic assays for orotic acid in milk (Anastasi et al. 2000) and malic acid in fruits, wines and other beverages and also...

absence of bait and assaying for growth on plates containing 5-fluoro-orotic acid (5-FOA). The protein product of URA3 converts 5-FOA into a toxic compound...

KORNBERG A (1955). "Enzymatic synthesis and breakdown of a pyrimidine, orotic acid. III Ureidosuccinase". J. Biol. Chem. 212 (2): 909–20. PMID 14353892...