p14ARF (also called ARF tumor suppressor, ARF, p14ARF) is an alternate reading frame protein product of the CDKN2A locus (i.e. INK4a/ARF locus). p14ARF...

for two proteins, including the INK4 family member p16 (or p16INK4a) and p14arf. Both act as tumor suppressors by regulating the cell cycle. p16 inhibits...

Gupta SD, Ralhan R (April 2007). "Promoter hypermethylation of p16INK4A, p14ARF, CyclinD2 and Slit2 in serum and tumor DNA from breast cancer patients"...

gene encoding the p21 protein. The p53 and RB1 pathways are linked via p14ARF, raising the possibility that the pathways may regulate each other. p53...

of the p14ARF tumor suppressor to block cell growth so it is commonly mutated or inhibited in cancer cells. The AML1-ETO is incapable of p14ARF transcription...

p16INK4a, which binds to CDK4 and arrests the cell cycle in G1 phase, and p14ARF which prevents p53 degradation. Synthetic inhibitors of Cdc25 could also...

8 9 10 11A 11B 12 13 14 CDK-activating kinase CDK inhibitor INK4a/ARF (p14arf/p16, p15, p18, p19) cip/kip (p21, p27, p57) P53 p63 p73 family p53 p63 p73...

Resonance Filter or atomic line filter Auxin Response Factors in plants p14arf or ARF tumor suppressor Arf (Nanoha), character in Magical Girl Lyrical...

p53-stabilizing signals. This loop can be interfered with by kinases and genes like p14arf when p53 activation signals, including DNA damage, are high. The full-length...

tumor suppressor. More specifically, P14ARF is a protein in which in humans is modulated by the PANO1 gene. P14ARF is known to function as a tumor suppressor...

cellular pathways, such as DNA repair (hMLH1, for example), cell cycle (p14ARF), apoptosis (DAPK), and cell adherence (CDH1, CDH13), are inactivated by...

suppressor genes:[citation needed] Neurofibromatosis type 2 at 22q12 P16INK4A P14ARF Asbestos has also been shown to mediate the entry of foreign DNA into target...

are two primary tumor suppressor pathways known to mediate senescence: p14arf/p53 and INK4A/RB. More specifically p16INK4a-pRb tumor suppressor and p53...

that is involved in activating T-cells), CDKN2A (encoding p16INK4a and p14arf tumor suppressor proteins) or CDKN2B (encoding cyclin dependent kinase inhibitor...

protein should not be confused with p19-ARF (mouse) or the human equivalent p14ARF, which are alternative products of the CDKN2A gene. GRCh38: Ensembl release...

cancer cell line growth and is involved in down-regulating the expression of p14ARF and p53". FEBS Lett. 586 (9): 1356–62. doi:10.1016/j.febslet.2012.03.053...

Hackenbroch M, Boström J, et al. (December 2001). "Alterations of INK4a(p16-p14ARF)/INK4b(p15) expression and telomerase activation in meningioma progression"...

melanoma may also be caused by germline mutations in the MC1R, MITF, and P14arf genes in addition to increased copy number gains in 8q24. Research findings...

The following is a partial list of the "D" codes for Medical Subject Headings (MeSH), as defined by the United States National Library of Medicine (NLM)...

Korshunov A, Golanov A (2002). "Immunohistochemical analysis of p18INK4C and p14ARF protein expression in 117 oligodendrogliomas: correlation with tumor grade...

Digiovanna JJ, et al. (September 2013). "Chimeric negative regulation of p14ARF and TBX1 by a t(9;22) translocation associated with melanoma, deafness,...

PMID 16354571. S2CID 24253878. Gjerset RA (September 2006). "DNA damage, p14ARF, nucleophosmin (NPM/B23), and cancer". Journal of Molecular Histology. 37...

2000.3882. PMID 11112409. Ivanchuk SM, Mondal S, Rutka JT (June 2008). "p14ARF interacts with DAXX: effects on HDM2 and p53". Cell Cycle. 7 (12): 1836–50...

cancer; abnormal methylation of tumor suppressor genes p16, CDKN2B, and p14ARF for brain cancer; hypermethylation of MYOD1, CDH1, and CDH13 for cervical...

polycomb members Bmi-1, Mel-18, and Hpc-2 in the regulation of p16INK4a, p14ARF, h-TERT, and c-Myc expression in primary breast carcinomas". Clinical Cancer...

cancer context, TBX3 directly represses the cell cycle regulators p19ARF/p14ARF, p21WAF1 and TBX2 as well as E-cadherin which encodes a cell adhesion molecule...

this includes the promoters of the genes CDKN2/p16, RB, PTEN, TP53 and p14ARF. Importantly, glioblastomas are known to have high frequency of methylation...

PMID 18254724. S2CID 13038944. Ivanchuk SM, Mondal S, Rutka JT (June 2008). "p14ARF interacts with DAXX: effects on HDM2 and p53". Cell Cycle. 7 (12): 1836–50...

(2002). "CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53". J. Biol. Chem. 277 (40): 37765–70. doi:10.1074/jbc...

using the knockout model of Tbx2 for study of tumorigenesis is limited. p14ARF/MDM2/p35/p21CIP1 Pathway. When up-regulated, Tbx2 inhibits p21CIP1. p21CIP1...