Proliferating cell nuclear antigen (redirect from PCNA)
antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication. PCNA is a homotrimer...
53 KB (6,158 words) - 18:54, 23 April 2024
acts as a small molecule inhibitor of proliferating cell nuclear antigen (PCNA) and is in Phase I clinical trials at City of Hope as of August 2023 for...
6 KB (572 words) - 19:06, 29 May 2024
P21 (section PCNA inhibition)
binding region on PCNA, binding of p21 to this region is proposed to block the binding of processivity factors necessary for PCNA dependent S-phase DNA...
34 KB (3,978 words) - 08:00, 23 February 2024
both PCNA and RFC, and produces mostly ligated DNA products. It is also found that under one condition where DNA polymerase epsilon require PCNA and RFC:...
3 KB (336 words) - 09:50, 4 November 2023
DNA mismatch repair (section PCNA β-sliding clamp)
(PCNA), in an orientation-specific manner, such that one face of the donut-shape protein is juxtaposed toward the 3'-OH end at the nick. Loaded PCNA then...
35 KB (4,179 words) - 12:12, 19 July 2024
proliferating cell nuclear antigen (PCNA). The N-terminal and C-terminal domains of PCNA are topologically identical. Three PCNA molecules are tightly associated...
23 KB (2,044 words) - 07:04, 10 March 2024
cell nuclear antigen (PCNA). As well, the multisubunit protein replication factor C, through its role as the clamp loader for PCNA (which involves catalysing...
2 KB (259 words) - 21:21, 11 December 2023
A Ramachandran plot generated from human PCNA, a trimeric DNA clamp protein that contains both β-sheet and α-helix (PDB ID 1AXC). The red, brown, and yellow...
16 KB (1,739 words) - 01:49, 14 August 2024
This diagram (which is interactive) of protein structure uses PCNA as an example. (PDB: 1AXC)...
15 KB (1,603 words) - 16:54, 15 June 2024
Proliferating cell nuclear antigen (PCNA) is a protein involved in DNA synthesis. Under normal physiological conditions PCNA is sumoylated (a similar post-translational...
98 KB (11,068 words) - 18:25, 16 July 2024
by the FEN1 and it creates a functional continuous double strand of DNA. PCNA simulates enzymatic functions of proteins for both FEN1 and DNA ligase. The...
33 KB (4,435 words) - 14:24, 7 June 2024
This diagram (which is interactive) of protein structure uses PCNA as an example. (PDB: 1AXC)...
36 KB (4,022 words) - 16:54, 15 June 2024
cell nuclear antigen (PCNA). Under normal circumstances, PCNA bound to polymerases replicates the DNA. At a site of lesion, PCNA is ubiquitinated, or modified...
129 KB (15,900 words) - 06:12, 13 August 2024
Wright JT (June 2018). "2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High...
126 KB (13,279 words) - 02:09, 15 August 2024
et al. (June 2019). "2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American...
100 KB (11,153 words) - 19:49, 23 July 2024
antigen (PCNA). The PCNA ring has polarity with surfaces that interact with DNA polymerases and tethers them securely to the DNA template. PCNA-dependent...
119 KB (14,646 words) - 22:02, 3 July 2024
The assembled human DNA clamp, a trimer of the protein PCNA...
60 KB (7,286 words) - 08:26, 2 July 2024
involves catalyzing the loading of PCNA onto DNA. It binds to the 3' end of the DNA and uses ATP to open the ring of PCNA so that it can encircle the DNA...
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hemimethylated DNA and interacts with the proliferating cell nuclear antigen (PCNA). By preferentially modifying hemimethylated DNA, DNMT1 transfers patterns...
161 KB (18,344 words) - 08:31, 28 July 2024
Bittl JA, Byrne JG, Fletcher BJ, et al. (November 2014). "2014 ACC/AHA/AATS/PCNA/SCAI/STS focused update of the guideline for the diagnosis and management...
105 KB (10,738 words) - 03:21, 13 August 2024
Blankenship JC, Dallas AP, et al. (December 2012). "2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable...
44 KB (3,692 words) - 16:39, 27 July 2024
This diagram (which is interactive) of protein structure uses PCNA as an example. (PDB: 1AXC)...
21 KB (2,342 words) - 16:59, 19 May 2024
rennlist.com. Retrieved 10 August 2017. "991.1 GT3 COG: Our Meeting with PCNA/PAG plus Porsche's Official Announcement". rennlist.com. Retrieved 10 August...
91 KB (10,449 words) - 06:48, 9 August 2024
et al. (June 2019). "2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American...
181 KB (17,324 words) - 15:24, 6 August 2024
et al. (June 2019). "2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American...
80 KB (8,530 words) - 10:23, 11 August 2024
the other subunits that interact with Proliferating Cell Nuclear Antigen (PCNA), which is a DNA clamp that allows Pol δ to possess processivity. Pol ε is...
59 KB (7,090 words) - 06:49, 30 June 2024
Cynopa pyrrhogaster, this transition was shown to involve expression of PCNA, a DNA polymerase delta auxiliary protein involved in DNA replication and...
36 KB (3,836 words) - 01:38, 28 June 2024
et al. (June 2019). "2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: Executive Summary: A Report...
111 KB (10,915 words) - 03:08, 12 August 2024
This diagram (which is interactive) of protein structure uses PCNA as an example. (PDB: 1AXC)...
21 KB (2,595 words) - 15:26, 27 May 2024
This diagram (which is interactive) of protein structure uses PCNA as an example. (PDB: 1AXC)...
28 KB (3,072 words) - 15:24, 4 February 2024