A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic nucleotide phosphodiesterases, which...
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A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), thereby preventing the inactivation...
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PDE5 inhibitor (redirect from Phosphodiesterase V inhibitors)
A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase...
16 KB (1,723 words) - 17:39, 13 September 2024
types of the enzyme phosphodiesterase 4 (PDE4) are known: PDE4A PDE4B PDE4C PDE4D 3',5'-cyclic-AMP phosphodiesterase Phosphodiesterase (PDE) PDE4 inhibitor...
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Cyclic guanosine monophosphate-specific phosphodiesterase type 5 is an enzyme (EC 3.1.4.17) from the phosphodiesterase class. It is found in various tissues...
16 KB (1,849 words) - 14:58, 23 May 2024
PDE4 inhibitor (redirect from Phosphodiesterase-4 inhibitors)
A phosphodiesterase-4 inhibitor, commonly referred to as a PDE4 inhibitor, is a drug used to block the degradative action of phosphodiesterase 4 (PDE4)...
18 KB (1,886 words) - 04:23, 15 August 2024
in a serious drop in blood pressure. Sildenafil acts by blocking phosphodiesterase 5 (PDE5), an enzyme that promotes breakdown of cGMP, which regulates...
83 KB (7,403 words) - 05:44, 29 September 2024
PDE3 is a phosphodiesterase. The PDEs belong to at least eleven related gene families, which are different in their primary structure, substrate affinity...
17 KB (1,900 words) - 05:37, 3 June 2024
Monophosphatidylinositol phosphodiesterase may refer to: Phosphatidylinositol diacylglycerol-lyase, an enzyme Phosphoinositide phospholipase C, an enzyme...
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PDE10A (redirect from Phosphodiesterase 10A)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A is an enzyme that in humans is encoded by the PDE10A gene. Various cellular responses...
10 KB (1,035 words) - 22:06, 27 March 2024
Sphingomyelin phosphodiesterase D (EC 3.1.4.41, sphingomyelinase D) is an enzyme of the sphingomyelin phosphodiesterase family with systematic name sphingomyelin...
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Phosphodiesterase 9 inhibitors or PDE9 inhibitors are a class of drugs that work by inhibiting the activity of PDE9. The first compound with this effect...
4 KB (367 words) - 20:46, 25 April 2024
phosphodiesterase (EC 3.1.4.52, cyclic bis(3′→5')diguanylate phosphodiesterase, c-di-GMP-specific phosphodiesterase, c-di-GMP phosphodiesterase, phosphodiesterase...
3 KB (308 words) - 22:55, 29 March 2024
Nucleotide pyrophosphatase/phosphodiesterase (NPP) is a class of dimeric enzymes that catalyze the hydrolysis of phosphate diester bonds. NPP belongs...
20 KB (1,857 words) - 01:10, 9 November 2023
(Tβγ). Activated transducin α-subunit activates cGMP phosphodiesterase. cGMP phosphodiesterase breaks down cGMP, an intracellular second messenger which...
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PDE1 (redirect from 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I)
Phosphodiesterase 1, PDE1, EC 3.1.4.1, systematic name oligonucleotide 5′-nucleotidohydrolase) is a phosphodiesterase enzyme also known as calcium- and...
22 KB (2,564 words) - 01:35, 14 June 2024
PDE3 inhibitor (redirect from Phosphodiesterase 3 inhibitor)
A PDE3 inhibitor is a drug which inhibits the action of the phosphodiesterase enzyme PDE3. They are used for the therapy of acute heart failure and cardiogenic...
11 KB (1,218 words) - 12:44, 30 April 2022
cAMP-specific 3',5'-cyclic phosphodiesterase 4D is an enzyme that in humans is encoded by the PDE4D gene. The PDE4D gene is complex and has at least 9...
15 KB (1,812 words) - 22:11, 27 March 2024
3′,5′-cyclic-nucleotide phosphodiesterases (EC 3.1.4.17) are a family of phosphodiesterases. Generally, these enzymes hydrolyze a nucleoside 3′,5′-cyclic...
7 KB (821 words) - 20:38, 7 December 2023
2′,3′-Cyclic-nucleotide 3'-phosphodiesterase (EC 3.1.4.37, CNPase, systematic name nucleoside-2′,3′-cyclic-phosphate 2′-nucleotidohydrolase) is an enzyme...
15 KB (1,637 words) - 17:42, 18 April 2024
The enzyme 2′,3′-cyclic-nucleotide 2'-phosphodiesterase (EC 3.1.4.16) catalyzes the reaction nucleoside 2′,3′-cyclic phosphate + H2O ⇌ {\displaystyle...
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Spleen exonuclease (redirect from Spleen phosphodiesterase)
exonuclease (EC 3.1.16.1, 3'-exonuclease, spleen phosphodiesterase, 3'-nucleotide phosphodiesterase, phosphodiesterase II) is an enzyme. This enzyme catalyses...
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The enzyme glycerophosphodiester phosphodiesterase ({EC 3.1.4.46) catalyzes the reaction a glycerophosphodiester + H2O ⇌ {\displaystyle \rightleftharpoons...
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mechanisms of action: cardiac glycosides, beta-adrenergic agonists, phosphodiesterase III inhibitors, and calcium sensitizers. It is important to note that...
57 KB (5,106 words) - 16:11, 11 August 2024
The PDE2 (phosphodiesterase 2) enzyme is one of 21 different phosphodiesterases (PDE) found in mammals. These different PDEs can be subdivided to 11 families...
25 KB (2,872 words) - 02:43, 7 March 2023
The enzyme glycerophosphocholine phosphodiesterase (EC 3.1.4.2) catalyzes the reaction sn-glycero-3-phosphocholine + H2O ⇌ {\displaystyle \rightleftharpoons...
2 KB (131 words) - 14:21, 26 August 2023
3′,5′-cyclic-AMP phosphodiesterase (EC 3.1.4.53, cAMP-specific phosphodiesterase, cAMP-specific PDE, PDE1, PDE2A, PDE2B, PDE4, PDE7, PDE8, PDEB1, PDEB2)...
3 KB (340 words) - 06:11, 28 November 2023
obstructive pulmonary disease (COPD) in adults. It is a phosphodiesterase 3 inhibitor and phosphodiesterase 4 inhibitor. It is given by inhalation. It is an...
8 KB (589 words) - 09:22, 14 September 2024
guanylate cyclase signaling also leads to anti-inflammatory effects. Phosphodiesterase type 5 (PDE5), which is abundant in the pulmonary tissue, hydrolyzes...
89 KB (8,895 words) - 04:45, 29 September 2024
the corpus cavernosum.[medical citation needed] The inhibition of phosphodiesterase type 5 (PDE5) enhances erectile function by increasing the amount...
35 KB (3,239 words) - 13:23, 19 September 2024