Properdin is a protein that in humans is encoded by the CFP (complement factor properdin) gene. Properdin is plasma glycoprotein that activates the complement...

Properdin deficiency is a rare X-linked disease in which properdin, an important complement factor responsible for the stabilization of the alternative...

Properdin (Factor P) is the only known positive regulator of complement activation that stabilizes the alternative C3 convertase (C3bBb). Properdin deficient...

beta globulins include: beta-2 microglobulin plasminogen angiostatins properdin sex hormone-binding globulin transferrin Ren Zhang; Yan Lin & Chun-Ting...

complex is believed to be unstable until it binds properdin, a serum protein. The addition of properdin forms the complex C3bBbP, a stable compound which...

Factor D (EC 3.4.21.46, C3 proactivator convertase, properdin factor D esterase, factor D (complement), complement factor D, CFD, adipsin) is a protein...

E, WARDLAW A (1954). "The properdin system and immunity. I. Demonstration and isolation of a new serum protein, properdin, and its role in immune phenomena"...

produces all types of blood cells during fetal life Production of opsonins, properdin, and tuftsin. Release of neutrophils following myocardial infarction....

glomerulus. As soon as binding occurs to the glomerulus, via interaction with properdin, the complement is activated. Complement fixation causes the generation...

conditions, while properdin deficiency occurs through X-linked inheritance. MBL deficiency can be inherited by either manner. Properdin deficiency is an...

less complete than that of complement non-deficient persons. Inherited properdin deficiency also is related, with an increased risk of contracting meningococcal...

Proliferating trichilemmal cyst Prolidase deficiency Prolymphocytic leukemia Properdin deficiency Prosencephaly cerebellar dysgenesis Prosopamnesia Prostaglandin...

cleaved by Factor D into Factor Bb. This C3bBb convertase is stabilized by properdin (Factor P) preferentially on microbial surfaces over normal host surfaces...

×10−5 C6 4.8-6.4 ×10−5 C7 4.9-7 ×10−5 C8 4.3-6.3 ×10−5 C9 4.7-6.9 ×10−5 Properdin 2.4-3.2 ×10−5 Compound S 1-3 ×10−9 Copper 9-15 ×10−7 male 7-14 ×10−7 female...

convertase. The C3bBb complex is stabilized by binding oligomers of factor P (properdin). The stabilized C3 convertase, C3bBbP, then acts enzymatically to cleave...

ED, Kriel J (December 1995). "DBP (vitamin D binding protein) and BF (properdin factor B) allele distribution in Namibian San and Khoi and in other South...

Immunofluorescence shows mesangial deposition of IgA often with C3 and properdin and smaller amounts of other immunoglobulins (IgG or IgM). Early components...

complement component C3/C5 convertase (alternative), proenzyme factor B, properdin factor B, C3 proactivator, glycine-rich beta-glycoprotein, heat-labile...

dissociation with a half-life at 37 °C of approximately 1.5 - 3 min. The properdin stabilizes the alternative pathway C5 convertase of which half-life is...

membranoproliferative glomerulonephritis) Factor D deficiency (Neisserial infections) Properdin deficiency (Neisserial infections) MBP deficiency (pyogenic infections)...

has the ability to catalyze the formation of C3a and C3b after it binds properdin, a globulin protein, and is stabilized. Anaphylatoxins are small complement...

the amino-terminal heparin-binding domain, the procollagen domain, the properdin-like type I repeats, and the globular carboxy-terminal domain. The protein...

conservation Louis Pillemer, (B.S. 1932), immunologist; discoverer of properdin John H. Sampson (Ph.D. 1996, M.B.A. 2011), world-renowned neurosurgeon...

(2015-01-07). "A War with the Molecules: Louis Pillemer and the History of Properdin". Perspectives in Biology and Medicine. 23 (4): 638–657. doi:10.1353/pbm...

Lachmann PJ, Harrison RA (August 1988). "Analysis of the interaction between properdin and factor B, components of the alternative-pathway C3 convertase of complement"...

to low levels of complement component 3 (C3), factor B, factor H and properdin in blood, due to unregulated activation of C3 convertase, and to low levels...

absence of recurrent pyogenic infection or features of lupus. They excluded properdin deficiency, which can be accompanied by susceptibility to meningococcal...

target population to be vaccinated based on risk assessment. Inherited properdin deficiency also is related with an increased risk of contracting meningococcal...

Mannan-binding lectin Alternative complement pathway Factor B Factor D Factor P (Properdin) Middle stage C3 - C3a / C3b / iC3b C5 - C5a C3-convertase C5-convertase...

vasculopathy and hydraencephaly-hydrocephaly syndrome; 225790; FLVCR2 Properdin deficiency, X-linked; 312060; PFC Propionicacidemia; 606054; PCCA Propionicacidemia;...