Proprotein convertase 2 (PC2) also known as prohormone convertase 2 or neuroendocrine convertase 2 (NEC2) is a serine protease and proprotein convertase...

activity. Proprotein convertases remove those chains and activate the protein. The prototypical proprotein convertase is furin. Proprotein convertases have...

Proprotein convertase 1, also known as prohormone convertase, prohormone convertase 3, or neuroendocrine convertase 1 and often abbreviated as PC1/3 is...

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme encoded by the PCSK9 gene in humans on chromosome 1. It is the 9th member of the proprotein...

160-amino acid protein proglucagon. Proglucagon is then cleaved by proprotein convertase 2 to glucagon (amino acids 33-61) in pancreatic islet α cells. In...

prodynorphin. When prodynorphin is cleaved during processing by proprotein convertase 2 (PC2), multiple active peptides are released: dynorphin A, dynorphin...

that belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins...

vesicles. In the granule, proinsulin is cleaved by proprotein convertase 1/3 and proprotein convertase 2, removing the middle part of the protein, called...

by the enzyme proprotein convertase 2 (PC2) while 16 are removed from the C-terminus of the proIAPP molecule by proprotein convertase 1/3 (PC1/3). At...

placenta and womb, and from the ovaries. Proprotein convertase 1 converts prorenin into renin, but proprotein convertase 2 does not. There is no evidence that...

preproinsulin signal peptide signal peptide peptidase proprotein convertase 1 (PC1) proprotein convertase 2 (PC2) "Entrez Gene: INS insulin". Bell GI, Pictet...

Evolocumab is a fully human monoclonal antibody that inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9). PCSK9 is a protein that targets...

a small interfering RNA (siRNA) that acts as an inhibitor of a proprotein convertase, specifically, inhibiting translation of the protein PCSK9. Inclisiran...

cleave the peptide precursors, which are small proteins. First, proprotein convertases cut the precursor at specific sites to generate intermediates containing...

Proprotein convertase subtilisin/kexin type 4 is an enzyme that in humans is encoded by the PCSK4 gene. GRCh38: Ensembl release 89: ENSG00000115257 –...

inactive hormones. Once prohormones are needed to be expressed, prohormone convertase, a protein, cleaves the prohormones and separates them into one or more...

Proprotein convertase subtilisin/kexin type 5 is an enzyme that in humans is encoded by the PCSK5 gene, found in chromosome 9q21.3 Two alternatively spliced...

Proprotein convertase subtilisin/kexin type 6 is an protease that in humans is encoded by the PCSK6 gene which is located in chromosome 15. Pcsk6 is a...

3.4.21.92: endopeptidase Clp EC 3.4.21.93: proprotein convertase 1 EC 3.4.21.94: proprotein convertase 2 EC 3.4.21.95: snake venom factor V activator...

"Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization". Proceedings...

Proprotein convertase subtilisin/kexin type 7 is an enzyme that in humans is encoded by the PCSK7 gene. The protein encoded by this gene belongs to the...

640 – proprotein convertase 1 MeSH D08.811.277.656.300.760.646 – proprotein convertase 2 MeSH D08.811.277.656.300.760.648 – proprotein convertase 5 MeSH D08...

anti-sense oligonucleopeptides (such as Pelacarsen and Olpasiran), and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors. The American Academy...

transcription factors. This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide...

of Sparassis crispa (Wulf.) and Their Inhibitory Activities on Proprotein Convertase Subtilisin/Kexin Type 9 mRNA Expression". J. Agric. Food Chem. 65...

neuroendocrine tissues. It functions as a chaperone protein for the proprotein convertase PC2 by blocking the aggregation of this protein, and is required...

added to other treatments for HoFH. Side effects that occurred in more than 2% of people treated with alirocumab in clinical trials and that occurred more...

is cleaved by proteins called convertases in order to generate a mature Nodal. The subtilisin-like proprotein convertases (SPC) Furin (Spc1) and PACE4...

Christian JL, Heasman J (February 2005). "XPACE4 is a localized pro-protein convertase required for mesoderm induction and the cleavage of specific TGFbeta proteins...

macrophages, monocytes, and a subset of dentritic cells known as slanDC, as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE)...