and replichores. In E. coli chromosomes, the origin and terminus of replication divide the genome into oppositely replicated halves called replichores. Replichore...

that were assembled at oriC during initiation proceed along each arm (replichore) of the chromosome, in opposite directions away from the oriC, replicating...

chromosome shows two main levels of global organization: macrodomains and replichores. Macrodomains were discovered by cytological studies. They contain loci...

lagging strand. GC or AT skew changes sign at the boundaries of the two replichores, which correspond to DNA replication origin or terminus. Originally,...