Retinal isomerase (EC 5.2.1.3) is an enzyme that catalyzes the isomerisation of all-trans-retinal in the eye into 11-cis-retinal which is the form that...

Drosophila has both retinal-forming carotenoid-oxygenase activity and all-trans to 11-cis isomerase activity. All-trans-retinal is also an essential...

biochemistry, cis-trans isomerase is a type of isomerase which catalyzes the isomerization of geometric isomers. Examples include retinal isomerase and immunophilins...

to 11-cis-retinal (the required photoactive visual pigment component). RPE65 is also referred to as retinol isomerase or retinoid isomerase, owing to...

isomerase Prolyl isomerase Retinal isomerase Retinol isomerase Zeta-carotene isomerase Category:EC 5.3.3 Enoyl CoA isomerase (EC 5.3.3.8) Category:EC 5...

is a process in the retina that replenishes the molecule retinal for its use in vision. Retinal is the chromophore of most visual opsins, meaning it captures...

catalyses the following chemical reaction beta-carotene + O2 → 2 all-trans-retinal This is a cleavage reaction which cleaves β-carotene, utilizes molecular...

of retinal . Oberhauser V, Voolstra O, Bangert A, von Lintig J, Vogt K (December 2008). "NinaB combines carotenoid oxygenase and retinoid isomerase activity...

includes an enzyme known as RPE65 which is abundantly expressed in the retinal pigment epithelium where it catalyzed the formation of 11-cis-retinol from...

The isomerase activity of RPE65 has been shown; it is uncertain whether it also acts as the hydrolase. Finally, it is oxidized to 11-cis-retinal before...

Dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2), also known as DCT, is a human gene. Its expression is regulated by the...

acts as an isomerase, converting all-trans-retinol to 11-cis-retinol in the visual cycle. Loss of this protein results in an early-onset retinal degeneration...

553 participants with macular edema due to branch retinal vein occlusion (BRVO) and central retinal vein occlusion (CRVO) in the BALATON and COMINO studies...

exists in virtually all life forms. The enzyme isopentenyl pyrophosphate isomerase catalyzes isomerization between DMAPP and IPP. In the mevalonate pathway...

pathways, IPP is isomerized to DMAPP by the enzyme isopentenyl pyrophosphate isomerase. IPP and DMAPP condense to give geranyl pyrophosphate, the precursor to...

diabetic retinopathy, and macular edema due to branch retinal vein occlusion or central retinal vein occlusion. Ranibizumab was developed by Genentech...

ranibizumab and pegaptanib, on patients who have macular edema caused by central retinal vein occlusion. Participants in both treatment groups showed improvement...

molecules. Specifically, TOP2B is required for lamina-specific targeting of retinal ganglion cell axons and dendrites in the zebrafish. TOP2B has been shown...

anaerobic environments. IPP is then able to isomerize to DMAPP via IPP isomerase. Two GGPP molecules condense via phytoene synthase (PSY), forming the...

Prostaglandin-H2 D-isomerase (PTGDS) is an enzyme that in humans is encoded by the PTGDS gene. The protein encoded by this gene is a glutathione-independent...

endophthalmitis (an infection inside the eye), retinal artery occlusion (blockage of the artery in the retina) and retinal detachment (separation of the retina...

hydrochloride, it is the first synthetic medicinal compound shown to affect retinal disease processes when taken by mouth. Emixustat was invented by the British-American...

Additional common adverse reactions include rash, anemia, epistaxis, serous retinal detachment, extremity pain, dyspepsia, blurred vision, peripheral edema...

pathways, IPP is isomerized to DMAPP by the enzyme isopentenyl pyrophosphate isomerase. Geranyl pyrophosphate is the precursor to monoterpenes (and hence monoterpenoids)...

the University of Pennsylvania. Her research focuses on gene therapy for retinal diseases. Her laboratory developed the first FDA approved gene therapy...

sickle cell anemia in Arabs article about Birth defects Glucose phosphate isomerase deficiency responsible for unexpected hemolytic episodes. one of late...

infection. When used for eye disease side effects can include vision loss and retinal detachment. Bevacizumab is a monoclonal antibody that functions as an angiogenesis...

to dimethylallyl pyrophosphate by the enzyme isopentenyl pyrophosphate isomerase. IPP can be synthesised via an alternative non-mevalonate pathway of isoprenoid...

emissions resembling that of retinal bound rhodopsin, the photosensor molecule bound to PYP should resemble the structure of retinal bound rhodopsin, the photosensor...

1 and 2 using NADPH to form (+)-cis-isopulegone. (+)-cis-Isopulegone isomerase (iPI) then isomerizes the remaining double bond to form (+)-pulegone....