SLX4 (also known as BTBD12 and FANCP) is a protein involved in DNA repair, where it has important roles in the final steps of homologous recombination...

study suggests that a scaffold protein called SLX4 may participate in this regulation. Specifically, SLX4 knockout mice largely phenocopies the MUS81 knockout—once...

SLX4 interacting protein is a protein that in humans is encoded by the SLX4IP gene. SLX4 interacting protein (SLX4IP) exists in a monomeric form, and interacts...

FANCI, FANCJ (BRIP1), FANCL, FANCM, FANCN (PALB2), FANCO (RAD51C), FANCP (SLX4), FANCQ (XPF), FANCS (BRCA1), FANCT (UBE2T), FANCU (XRCC2), FANCV (REV7)...

genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures...

It is this complex that recruits FAN1 as well as other nucleases such as SLX4. Ubiquinated FANCD2 interacts with the FAN1 nuclease. Upon its recruitment...

P0DP57 15266 SLX1A HGNC:20922 Q9BQ83 15267 SLX1B HGNC:28748 Q9BQ83 15268 SLX4 HGNC:23845 Q8IY92 15269 SLX4IP HGNC:16225 Q5VYV7 15270 SLX9 HGNC:15811 Q9NSI2...

MiDAS essential scaffolding protein SLX4, which forms a large nuclease complex. The proposed mechanisms for TOPBP1/SLX4 mediated MiDAS are either replication...

member 9 SLC2A4RG: encoding protein SLC2A4 regulator SLX4IP: encoding protein SLX4 interacting protein SNPH: encoding protein Syntaphilin SPATA2: encoding protein...

discoveries of genes implicated in disease, including finding: Mutation of SLX4 causes a new type of Fanconi anemia. Nine new genes that influence bone strength...

nucleases, known as Rad1/Rad10, which are brought to the flaps by the Saw1 and Slx4 proteins. New DNA synthesis fills in any gaps, and ligation restores the...

Unhooking DNA Interstrand Crosslinks in Cooperation with FANCD2 and FANCP/SLX4". Molecular Cell. 54 (3): 460–471. doi:10.1016/j.molcel.2014.03.015. PMC 5067070...

Unhooking DNA interstrand crosslinks in cooperation with FANCD2 and FANCP/SLX4". Molecular Cell. 54 (3): 460–71. doi:10.1016/j.molcel.2014.03.015. PMC 5067070...

avoid ATM kinase activation through the creation of a terminal structure. SLX4, which is important in DNA repair by acting as a scaffold for structure-specific...

junction processing in human cells involving BLM-topoIIIα-RMI1-RMI2 (BTR), SLX1-SLX4-MUS81-EME1-ERCC1-XPF (SMX) and GEN1. His laboratory discovered that the Holliday...

interstitial nephritis. To this end, Smogorzewska has successfully identified SLX4, RAD51 and UBE2T as interstrand crosslink repair factors, as well as developed...

Svendsen JM, Smogorzewska A, Sowa ME, et al. (2009). "Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair"....

K; Arends, M. J.; Adams, D. J.; Patel, K. J. (2011). "Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia"...

Unhooking DNA interstrand crosslinks in cooperation with FANCD2 and FANCP/SLX4". Molecular Cell. 54 (3): 460–71. doi:10.1016/j.molcel.2014.03.015. PMC 5067070...

protein FANCO is also known as RAD51C. FANC protein FANCP is also known as SLX4. FANC+Proteins at the U.S. National Library of Medicine Medical Subject Headings...

O'Connell BC, Gygi SP, Elledge SJ, Harper JW (Jul 2009). "Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair"....