interaction molecule 1 is a protein that in humans is encoded by the STIM1 gene. STIM1 has a single transmembrane domain, and is localized to the endoplasmic...
7 KB (866 words) - 22:44, 13 November 2023
channel. ORAI1 interacts with the STIM1 protein. STIM1 is a transmembrane protein of the endoplasmic reticulum (ER). STIM1 can sense the concentration of...
11 KB (1,392 words) - 22:41, 16 July 2024
calcium concentration in the endoplasmic reticulum is sensed by the STIM1 protein. STIM1 clusters upon the depletion of the calcium stores and forms "puncta"...
6 KB (791 words) - 22:47, 13 November 2023
(STIM) family which comprises only two members together with its homologue STIM1, and likely arose from a common ancestral gene. They encode type 1 transmembrane...
34 KB (4,149 words) - 02:30, 28 March 2024
vertebrates. STIMATE can physically associate with STIM1 to promote conformational switch of STIM1 from inactive toward an activated state, thereby coupling...
4 KB (412 words) - 00:07, 17 October 2023
peptide and the transmembrane domain derived from STIM1, with GFP placed in between as a reporter. STIM1 is an ER-resident calcium sensor protein responsible...
6 KB (655 words) - 15:31, 17 October 2023
calcium into the cytosol. Low calcium in the endoplasmic reticulum causes STIM1 clustering on the ER membrane and leads to activation of cell membrane CRAC...
71 KB (9,026 words) - 12:33, 26 April 2024
configuration with the stromal interaction molecule 1 gene (STIM1), with the 3' end of STIM1 situated 1.6 kb from the 5' end of this gene. Click on genes...
8 KB (988 words) - 00:47, 4 March 2023
into the cytosol. The resulting low Ca2+ concentration in the ER causes STIM1 clustering on the ER membrane, which in turn leads to activation of cell...
43 KB (5,370 words) - 03:09, 26 June 2024
Salvatore (2023-05-08). "Muscle magnetic resonance characterization of STIM1 tubular aggregate myopathy using unsupervised learning". PLOS ONE. 18 (5):...
69 KB (4,051 words) - 18:14, 10 July 2024
ICRAC occurs are currently still under investigation. Although Orai1 and STIM1, have been linked by several studies, for a proposed model of store-operated...
19 KB (2,271 words) - 18:47, 25 March 2024
studied +TIPs. EB Proteins EB1 and other proteins SxlP proteins APC MACF STIM1 TOG proteins XMAP215 CLASP Motor proteins Tea2 MCAK Dynein HC Other proteins...
8 KB (875 words) - 07:52, 27 May 2024
phospholipid. The protein ensures proper stromal interaction molecule 1 (STIM1) recruitment to these sites of membrane contact as part of the store-operated...
2 KB (258 words) - 02:00, 3 December 2023
NEMO deficiency IKBA deficiency Calcium channel defects ORAI1 deficiency STIM1 deficiency Transcobalamin 2 deficiency Immunodeficiency with multiple intestinal...
19 KB (1,836 words) - 09:52, 5 July 2024
shown that tyrosine phosphorylation of VE-PTP via Pyk2 kinase downstream of STIM1-induced calcium entry mediates disassembly of the endothelial adherens junctions...
7 KB (792 words) - 01:09, 4 March 2023
HGNC:26239 Q9H5V9 15952 STH HGNC:18839 Q8IWL8 15953 STIL HGNC:10879 Q15468 15954 STIM1 HGNC:11386 Q13586 15955 STIM2 HGNC:19205 Q9P246 15956 STIMATE HGNC:30526...
242 KB (17 words) - 23:17, 27 April 2024
Ca2+ channel in human cells, and investigated the regulation of ORAI1 by STIM1, a single-pass transmembrane protein located in the membrane of the endoplasmic...
13 KB (1,404 words) - 16:18, 12 December 2023
Shcheglovitov, A.; Dolmetsch, R. (2010-10-01). "The CRAC channel activator STIM1 binds and inhibits L-type voltage-gated calcium channels". Science. 330...
16 KB (1,624 words) - 10:18, 17 June 2024
Andrea; Penner, Reinhold (July 2006). "Amplification of CRAC current by STIM1 and CRACM1 (Orai1)". Nature Cell Biology. 8 (7): 771–773. doi:10.1038/ncb1435...
8 KB (942 words) - 09:15, 27 December 2023
and Orais, however, have more recently been implicated in this process. STIM1 and TRPC1 can coassemble, complicating the understanding of this phenomenon...
10 KB (1,157 words) - 00:28, 17 July 2024
containing ER Ca2+ sensor protein, stromal interaction molecule 1 and 2 (STIM1, STIM2), has been shown to contain a Ca2+-binding canonical EF-hand motif...
17 KB (2,077 words) - 14:28, 10 June 2024
genetic and environmental, the congenital myopathies associated with genes STIM1 and ORAI1 are known as tubular aggregate myopathy (TAM) types 1 and 2. Currently...
20 KB (2,194 words) - 09:39, 18 March 2024
ORAI1 is a molecular component of the CRAC, and it interacts with STIM1 an ER protein. STIM1 can rapidly translocate to a PM-ER contact site after depletion...
17 KB (2,060 words) - 04:54, 27 May 2024
endoplasmic reticulum (ER) membrane resident protein that associates with STIM1, to facilitate the inactivation of SOCE. SARAF plays a key role in shaping...
4 KB (589 words) - 17:52, 13 October 2022
Choi M, Richardson AS, Reid BM, Seymen F, Yildirim M, et al. (July 2014). "STIM1 and SLC24A4 Are Critical for Enamel Maturation". Journal of Dental Research...
2 KB (227 words) - 19:54, 3 March 2023
regulates levels of osteoprotegerin. CaV1.2 is inhibited by the action of STIM1. The activity of CaV1.2 channels is tightly regulated by the Ca2+ signals...
22 KB (2,667 words) - 00:53, 17 July 2024
Nieswandt, Bernhard; Besnard, Philippe; Khan, Naim Akhtar (June 2012). "STIM1 regulates calcium signaling in taste bud cells and preference for fat in...
15 KB (1,465 words) - 23:44, 7 July 2024
has been shown to interact with: NSF, SNAP23, STX1A, STX4, STX5. ORAI1, STIM1. GRCh38: Ensembl release 89: ENSG00000105402 – Ensembl, May 2017 GRCm38:...
12 KB (1,551 words) - 05:31, 15 January 2024
Co-expression of Orai1 or Orai2 with the Intracellular Calcium Sensor, Stim1". J. Biol. Chem. 281 (34): 24979–90. doi:10.1074/jbc.M604589200. PMC 1633822...
5 KB (427 words) - 23:58, 3 March 2023
Tiruppathi C (Apr 2017). "Pyk2 Phosphorylation of VE-PTP Downstream of STIM1 induced Ca2+ entry Regulates Disassembly of Adherens Junctions". American...
16 KB (1,887 words) - 08:02, 10 July 2024