Siglecs (Sialic acid-binding immunoglobulin-type lectins) are cell surface proteins that bind sialic acid. They are found primarily on the surface of...

CD33 or Siglec-3 (sialic acid binding Ig-like lectin 3, SIGLEC3, SIGLEC-3, gp67, p67) is a transmembrane receptor expressed on cells of myeloid lineage...

Sialoadhesin (SIGLEC-1) is a cell adhesion molecule found on the surface of macrophages. It is found in especially high amounts on macrophages of the spleen...

They found that 9 of the 12 marketed Siglec-Fc reagents bind to HeLa cells, and two of which, Siglec-11 and Siglec-14, had binding that was vulnerable...

of the SIGLEC9 gene. Within the siglec family of transmembrane proteins, Siglec-8 belongs to the CD33-related siglec subfamily, a subfamily that has undergone...

PMID 9373149. Cornish AL, Freeman S, Forbes G, et al. (1998). "Characterization of siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33". Blood...

sixth member of the SIGLEC family of receptors to be identified. The protein has also been given the CD designation CD327. Siglec-6 was first found to...

Sialic acid binding Ig-like lectin 15 (Siglec-15) is a protein that in humans is encoded by the SIGLEC15 gene. Siglec-15 is predominately expressed on osteoclasts...

L1 (protein), CHL1, Neurofascin and NrCAM SIGLEC family including Myelin-associated glycoprotein (MAG, SIGLEC-4), CD22 and CD83 CTX family including CTX...

mammalian glycan-binding proteins (GBPs): C-type lectin, galectin, and SIGLEC immune receptors that bind carbohydrates: CD1, T cell receptor, and anti-carbohydrate...

a humanized, nonfucosylated IgG1 monoclonal antibody that targets Siglec-8. Siglec-8 is an inhibitory receptor present on eosinophils and mast cells,...

these osteoblasts can worsen tumors in two ways. First, they can induce SiglecFhigh-expressing neutrophil formation that in turn promotes lung tumor growth...

inhibitory receptor Siglec-11, but induces an opposing response through interactions with the paired activating receptor Siglec-16, exemplifying the...

Crocker PR (Dec 1999). "Identification and characterization of a novel siglec, siglec-7, expressed by human natural killer cells and monocytes". J Biol Chem...

Myelin-associated glycoprotein (MAG, Siglec-4) is a type 1 transmembrane protein glycoprotein localized in periaxonal Schwann cell and oligodendrocyte...

CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a...

MedlinePlus Overview bonecancer Wang Y, Zhan X, et al. (January 22, 2024). "Siglec-15/sialic acid axis as a central glyco-immune checkpoint in breast cancer...

characterization, and phylogenetic analysis of siglec-9, a new member of the CD33-related group of siglecs. Evidence for co-evolution with sialic acid synthesis...

CD8+T 2 HLA-E SHP-1, SHP-2 CD31 My, platelet, EC, T, NK 1 CD31 SHP-1, SHP-2 SIGLEC family Hm 1-4 Sialic acid SHP-1, SHP-2 CD66 Hm, EC 2 CD66 SHP-1, SHP-2 ILTs/LIRs...

an extracellular domain with a siglec-like immunoglobulin fold that substitutes hydrophobic interactions for the siglec fold's characteristic disulfide...

Vadastuximab talirine is an antibody-drug conjugate (ADC) directed to CD33 (siglec-3) which is a transmembrane receptor expressed on cells of myeloid lineage...

an extracellular domain with a siglec-like immunoglobulin fold that substitutes hydrophobic interactions for the siglec fold's characteristic disulfide...

its N-terminus. It is a member of the immunoglobulin superfamily and the SIGLEC family. CD22 functions as an inhibitory receptor for B cell receptor (BCR)...

charged carboxyl group at C1. Sialidosis Sialoglycoprotein Sialyltransferase Siglec Orthomyxoviridae Varki, Ajit; Roland Schauer (2008). "Sialic Acids". in...

neutrophils, macrophages, dendritic cells and activated T-cells (SIGLEC9). SIGLECs 7 and 9 suppress the immune function of these cells by binding to terminal...

AP; Rasmussen, HS; Rothenberg, ME; Hirano, I (22 October 2020). "Anti-Siglec-8 Antibody for Eosinophilic Gastritis and Duodenitis". The New England Journal...

PMID 1349172. Chen, Guo-Yun; Tang, Jie; Zheng, Pan; Liu, Yang (2009). "CD24 and Siglec-10 Selectively Repress Tissue Damage–Induced Immune Responses". Science...

the SIGLEC10 gene. Siglec-G is often referred to as the murine paralog of human Siglec-10 Like most but not all other Siglecs, Siglec-10 bears an ITIM (Immunoreceptor...

PILR-associating neural protein (PANP), HSV-1 glycoprotein B PILRA, PILRB SIGLEC family Endogenous and pathogen-derived sialylated glycans SIGLEC1, SIGLEC8...

the mechanism by which this occurs is not yet fully understood. Recently, Siglec-15 has also been identified as an immune suppressive molecule that is solely...